Open Access Medical Books


Edited by Jorge Esparza-Gordillo and Itaru Dekio .
414 pages . 

Atopic Dermatitis is a common disease characterized by inflamed, itching and dry 
skin. This relapsing allergic disorder has complex etiology and shows a remarkably 
high clinical heterogeneity which complicates the diagnosis and clinical management.
This book is divided into 4 sections. The first section (Disease Etiology) describes some of 
the physiological mechanisms underlying Atopic Dermatitis, including alterations in the 
immune system and the skin-barrier function. The important role of host-microorganism 
interactions on the pathophysiology of Atopic Dermatitis is discussed in the second 
section (Microorganisms in Atopic Dermatitis). An overview of the clinical diagnostic 
criteria and the disease management protocols commonly used is given in the third 
section (Diagnosis and Clinical Management). The last section (New Treatments) 
describes new therapeutic approaches that are not widely used but are currently being 
studied due to preliminary evidence showing a clinical benefit for Atopic Dermatitis.
As a co-editor, it was my greatest pleasure to work with Dr Jorge Esparza-Gordillo on 
this book, which handles cutting-edge ideas on atopic dermatitis, provided by 
ambitious specialists. Every chapter is a real pearl of the subject, and as a clinicianscientist, 
I was delighted to read the manuscript one by one. I believe clinicians and 
researchers worldwide will benefit from this book as a unique free online publication.
Thanks to Ms. Bojana Zelenika and Mr. Dejan Grgur of InTech - Open Access 
Publisher, this book is published with a very quick publication process, and will thus 
reach the reader with the latest information. Last but not least, I thank my wife Shoko 
for her enormous support during this project.

Itaru Dekio, MD, PhD
Department of Dermatology, Faculty of Medicine,
Shimane University, Izumo,


Part 1 Disease Etiology 1

Chapter 1 Flaky Tail Mouse as a Novel Animal 
Model of Atopic Dermatitis: Possible Roles
of Filaggrin in the Development of Atopic Dermatitis 3
Catharina Sagita Moniaga and Kenji Kabashima

Chapter 2 Mouse Models for Atopic Dermatitis Developed in Japan 21
Hiromichi Yonekawa, Toyoyuki Takada, Hiroshi Shitara, Choji Taya, Yoshibumi Matsushima, Kunie Matsuoka and Yoshiaki Kikkawa

Chapter 3 The Roles of Th2-Type Cytokines in the 
Pathogenesis of Atopic Dermatitis 39
Kenji Izuhara, Hiroshi Shiraishi, Shoichiro Ohta, Kazuhiko Arima and Shoichi Suzuki

Chapter 4 Epidermal Serine Proteases and Their 
Inhibitors in Atopic Dermatitis 51
Ulf Meyer-Hoffert

Chapter 5 The Role of Prostanoids in Atopic Dermatitis 65
Tetsuya Honda and Kenji Kabashima

Chapter 6 Expression and Function of CCL17 in Atopic Dermatitis 81
Susanne Stutte, Nancy Gerbitzki, Natalija Novak and Irmgard Förster

Part 2 Microrganisms in Atopic Dermatits 105

Chapter 7 Microorganisms and Atopic Dermatitis 107
Itaru Dekio

Chapter 8 Atopic Dermatitis and Skin Fungal Microorganisms 123
Takashi Sugita, Enshi Zhang, Takafumi Tanaka, Mami Tajima, Ryoji Tsuboi, Yoshio Ishibashi, Akemi Nishikawa

Chapter 9 Fungus as an Exacerbating Factor of Atopic Dermatitis,
and Control of Fungi for the Remission of the Disease 141
Takuji Nakashima and Yoshimi Niwano

Part 3 Diagnosis and Clinical Management 159

Chapter 10 Atopic Dermatitis: 
From Pathophysiology to Diagnostic Approach 161
Nicola Fuiano and Cristoforo Incorvaia

Chapter 11 Advances in Assessing the Severity 
of Atopic Dermatitis 169
Zheng-Hong Di, Li Zhang, Ya-Ni Lv, Li-Ping Zhao, Hong-Duo Chen and Xing-Hua Gao

Chapter 12 Physical and Chemical Factors that Improve 
Epidermal Permeability Barrier Homeostasis 197
Mitsuhiro Denda

Chapter 13 Trigger Factors, Allergens 
and Allergy Testing in Atopic Dermatitis 213
Evmorfia Ladoyanni

Chapter 14 Food Allergy in Atopic Dermatitis 229
Geunwoong Noh and Jae Ho Lee

Chapter 15 Clinical Management of Atopic Dermatitis 251
Soheyla Mahdavian, Patty Ghazvini, Luis Pagan, Angela Singh and Todd Woodard

Part 4 New Treatments 267

Chapter 16 Occlusive Therapy in Atopic Dermatitis 269
Misha M. Heller, Eric S. Lee,Faranak Kamangar, Wilson Liao and John Y. M. Koo

Chapter 17 Suplatast Tosilate for Prophylaxis of Pediatric Atopy 289
S. Yoshihara, M. Ono, Y. Yamada, H. Fukuda, T. Abe and O. Arisaka

Chapter 18 Thinking Atopic Dermatitis Treatment Differently: 
Specific Immunotherapy as an Option 299
Massimo Milani

Chapter 19 Improvement of Atopic Dermatitis 
by Human Sebaceous Fatty Acids and Related Lipids 309
Hiroyuki Araki, Yoshiya Sugai and Hirofumi Takigawa

Chapter 20 Probiotics and Atopic Dermatitis 325
Feriel Hacini-Rachinel, Ivana Jankovic, Anurag Singh and Annick Mercenier

Chapter 21 The Role of Probiotics in Atopic 
Dermatitis Prevention and Therapy 353
Öner Özdemir

Chapter 22 Food Compounds Inhibit Staphylococcus Aureus Bacteria 
and the Toxicity of Staphylococcus Enterotoxin A (SEA) Associated with Atopic Dermatitis 387
Reuven Rasooly and Mendel Friedman .

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Published by: Unknown - Wednesday, January 30, 2013


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