Open Access Medical Books


Edited by Yahwardiah Siregar .
496 pages .

It took a long journey to really understand what cancer is, although many researcher 
are still working of finding a definite answer on how to treat cancer, and, what is more 
important, how to detect cancer very early, when some cells start going abnormal and 
transform into cancer cells.
The immune system might be the best weapon against cancer, since immune defense is 
programmed to recognize and destroy abnormal cells, but cancer cells may develop 
many defenses against immune attacks. Advances in biological processes, including 
apoptosis and cell proliferation, that are known to be dysregulated in tumors need to 
be understood in molecular mechanisms. During the last decade, scientists have 
shown an interest to create cancer vaccines as well as DNA vaccines using 
development of new biotechnological tools to elucidate an immune attack against 
Recently, a new players in cancer biology have appeared: microRNAs (miRs or 
miRNAs), a class of small non-coding RNAs that play important roles in cell 
differentiation, cell growth and cell death. miRNAs can act either as oncogenes or 
tumor suppressors and regulate the interaction between cancer cells and the 
microenvironment. Understanding the function of ncRNAs by focusing on the 
potential involvement of specific RNA species, such as microRNAs, small nucleolar 
RNAs, Piwi-interacting RNA, long non-coding RNAs, in the development and
progression of cancer is described in this book.
The book was written not only for medical students, but it can also be widely used by 
clinical and biomedical scientists, as well as by doctors studying for their postgraduate 
My thanks are specifically aimed at Intech Open staff (Ms. Reinic, Ms. Blecic, Mr.
Greblo and Ms Zgela) who helped finish this book. I would also like to express my 
thankfulness to all authors who contributed a chapter to this publication. Finally, I 
hope this book will be useful to the health of mankind worldwide.

Yahwardiah Siregar


Section 1 HER2 Carcinogenesis: Etiology, Treatment and Prevention 1

Chapter 1 Serial Changes in Expression of Proteins in Response to 
Neoadjuvant Chemotherapy in Breast Cancer 3
Daniel Chan and Soo-Chin Lee

Chapter 2 HER2-Driven Carcinogenesis: 
New Mouse Models for Novel Immunotherapies 39
Cristina Marchini, Lucia Pietrella, Cristina Kalogris, Chiara Garulli, Federico Gabrielli, Elena Quaglino, Manuela Iezzi, Serenella M. Pupa, Elda Tagliabue and Augusto Amici

Chapter 3 HER2 Amplification or Overexpression in Upper GI Tract and 
Breast Cancer with Clinical Diagnosis and Treatment 67
Zhongren Zhou and David G. Hick

Section 2 DNA Repair Mechanism and Cancer 91

Chapter 4 Emerging Roles of Atypical Dual 
Specificity Phosphatases in Cancer 93
Erica L. Cain and Alexander Beeser

Chapter 5 DNA Repair Molecules 
and Cancer Therapeutical Responses 117
Yasuko Kitagishi, Mayumi Kobayashi and Satoru Matsuda

Section 3 A New Role of Oncogenes and Tumorsuppressorgenes 129

Chapter 6 Structure-Based Approaches Targeting Oncogene 
Promoter G-Quadruplexes 131
Dik-Lung Ma, Victor Pui-Yan Ma, Ka-Ho Leung, Hai-Jing Zhong, Hong-Zhang He, Daniel Shiu-Hin Chan and Chung-Hang Leung

Chapter 7 Cancer Genes and Chromosome Instability 151
Alexey Stepanenko and Vadym Kavsa

Chapter 8 Human Papillomaviruses Oncoproteins 183
Gabriela Anton, Adriana Plesa, Coralia Bleotu, Anca Botezatu, Mariana Anton, Lorelei Irina Brasoveanu and Mihai Stoian

Section 4 A New Approach on Cancer Mechanism 207

Chapter 9 Model Systems Facilitating an Understanding 
of Mechanisms for Oncogene Amplification 209
Takaaki Watanabe

Chapter 10 MLL Gene Alterations in Acute Myeloid 
Leukaemia (11q23/MLL+ AML) 225
Denisa Ilencikova and Alexandra Kolenova

Chapter 11 Dual Role of TLR3 in Inflammation 
and Cancer Cell Apoptosis 247
Yann Estornes, Olivier Micheau, Toufic Renno and Serge Lebecque

Chapter 12 A Different Approach for Cellular Oncogene Identification Came from Drosophila Genetics 271
Laura Monica Magdalena and Lorand Savu

Section 5 Non Coding RNA and Micro RNA in Tumorigenesis 293

Chapter 13 Post-Transcriptional Regulation of 
Proto-Oncogene c-fms in Breast Cancer 295
Ho-Hyung Woo and Setsuko K. Chambers

Chapter 14 Non-Coding RNAs and Cancer 317
Gianpiero Di Leva and Michela Garofalo 

Chapter 15 MiRNA and Proline Metabolism in Cancer 359
Wei Liu and James M. Phang

Chapter 16 microRNA: New Players in Metastatic Process 391
Tiziana Triulzi, Marilena V. Iorio, Elda Tagliabue and Patrizia Casalini

Chapter 17 Is CCDC26 a Novel Cancer-Associated Long-Chain Non-Coding RNA? 415
Tetsuo Hirano

Section 6 Oncogenes for Transcription Factors 435

Chapter 18 The MYCN Oncogene 437
Leanna Cheung, Jayne E. Murray, Michelle Haber and Murray D. Norris

Chapter 19 STAT Transcription Factors in Tumor Development and 
Targeted Therapy of Malignancies 455
Gordana Konjević, Sandra Radenković, Ana Vuletić, 
Katarina Mirjačić Martinović, Vladimir Jurišić and Tatjana Srdić . 

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Published by: Unknown - Tuesday, January 29, 2013


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