Open Access Medical Books



Edited by Angelo Squeri .

270 pages . 
Open Access .

Coronary Artery disease is one of the leading causes of death in industrialized  countries and is responsible for one out of every six deaths in the United States.
Remarkably, coronary artery disease is also largely preventable. The pathogenesis is  complex and involves many different pathways that are only partially understood.
Recently, the morbidity and mortality of ischaemic heart disease have substantially improved because of progress in therapeutic strategies, represented by the dramatic evolution of percutaneous coronary intervention. The biggest challenge in the next years is, however, to reduce the incidence of coronary artery disease worldwide.
A complete knowledge of the mechanisms responsible for the development of ischaemic heart disease is an essential prerequisite to a better management of this pathology improving prevention and therapy.
This monograph deals with the pathophysiology of atherosclerosis with emphasis on epigenetics, metabolomics, inflammation, molecular and cellular mechanisms involved in cardiovascular disease development.
This book has been written with the intention of providing new concepts about coronary artery disease pathogenesis that may link various aspects of the disease, going beyond the traditional risk factors.

Angelo Squeri, MD

Maria Cecilia Hospital – GVM Care & Research


Part 1 Pathogenesis 

  1 Gene Polymorphism and Coronary Heart Disease 3 Nduna Dzimiri

  2 Lipoprotein(a) Oxidation, Autoimmune and Atherosclerosis 49 
Jun-Jun Wang

  3 ICAM-1: Contribution to Vascular Inflammation and Early Atherosclerosis 65 
Sabine I. Wolf and Charlotte Lawson

  4 Molecular and Cellular Aspects of Atherosclerosis: Emerging Roles of TRPC Channels 91 
Guillermo Vazquez, Kathryn Smedlund, Jean-Yves K. Tano and Robert Lee

  5 Hypoxia-Regulated Pro- and Anti-Angiogenesis in the Heart 103 
Angela Messmer-Blust and Jian Li

  6 Paraoxonase 1 (PON1) Activity, Polymorphisms and Coronary Artery Disease 115 
Nidhi Gupta, Kiran Dip Gill and Surjit Singh

Part 2 Acute Coronary Syndrome 

Chapter 7 Acute Coronary Syndrome: Pathological Findings by Means of Electron Microscopy, Advance Imaging in Cardiology 139 
Mohaddeseh Behjati and Iman Moradi

Chapter 8 Shortened Activated Partial Thromboplastin Time (APTT): A Simple but Important Marker of Hypercoagulable State During Acute Coronary Event 157 
Wan Zaidah Abdullah

Part 3 Cardiovascular Prevention 

Chapter 9 Individualized Cardiovascular Risk Assessment 169 Eva Szabóová

Chapter 10 Metabolomics in Cardiovascular Disease: Towards Clinical Application 207 
Ignasi Barba and David Garcia-Dorado

Chapter 11 Novel Regulators of Low-Density Lipoprotein Receptor and Circulating LDL-C for the Prevention and Treatment of Coronary Artery Disease 225 
Guoqing Cao, Robert J. Konrad, Mark C. Kowala and Jian Wang

Chapter 12 Serum Choline Plasmalogen is a Reliable Biomarker for Atherogenic Status 243 
Ryouta Maeba and Hiroshi Hara . 

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Published by: younes younes - Thursday, January 31, 2013


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