Open Access Medical Books



Edited by Nobumi Tagaya ,

Open Access .

Liver biopsy is a procedure that involves obtaining a small piece of liver tissue, which is then analyzed in the laboratory. Liver biopsy may be used to evaluate a mass seen on ultrasound, CT or MRI images, diagnose unexplained liver diseases or abnormal liver function tests, determine the severity of the liver diseases including non-alcoholic liver disease, certain liver disease such as chronic hepatitis B or C, primary biliary cirrhosis, primary sclerosing cholangitis, autoimmune hepatitis, hemochromatosis or Wilson’s disease, and monitor the liver after a liver transplantation. Liver biopsy is a safe procedure when performed by an experienced doctor. However, it is an invasive procedure, and the common problems include mild pain and a decrease in blood pressure. Although more serious complications such as bleeding, infection, and injury of nearby organs are rare but potentially lethal, the monitoring within 24 hours after the liver biopsy is important. This book describes the role, indication, contraindication, technique and evaluation of outcome of liver biopsy. I believe that it will be greatly useful to the readers. Furthermore, this book introduces transgastric liver biopsy using NOTES technique and non-invasive alternatives including elastography and computer analysis of liver fibrosis as new tools for the evaluation of liver diseases.

Nobumi Tagaya, M.D., Ph.D.

Department of Surgery,
Dokkyo Medical University Koshigaya Hospital,
Koshigaya, Saitama,


Section 1 An Overview and Future Aspects of Liver Biopsy .

  1 Liver Biopsy - Indications, Procedures, Results 3 
Claudia Randazzo, Anna Licata and Piero Luigi Almasio

  2 Types of Liver Biopsy 23 
Nobumi Tagaya, Nana Makino, Kazuyuki Saito, Takashi Okuyama, Yoshitake Sugamata and Masatoshi Oya

  3 Rethinking the Role of Liver Biopsy in the Era 
of Personalized Medicine 33 Teresa Casanovas Taltavull

Section 2 Clinical Practice of Liver Biopsy .

  4 Safety and Reliability Percutaneous Liver Biopsy Procedure in 
Children with Chronic Liver Diseases 75 Anna Mania, Paweł Kemnitz, Magdalena Figlerowicz, Aldona Woźniak and Wojciech Służewski

  5 Risks and Benefits of Liver Biopsy in Focal Liver Disease 85 
Letiția Adela Maria Streba, Eugen Florin Georgescu and Costin Teodor Streba

  6 Current Trends in Liver Biopsy Indications for 
Chronic Liver Diseases 103 Jean-François Cadranel and Jean-Baptiste Nousbaum

  7 Primary and Metastatic Tumours of the Liver: Expanding Scope 
of Morphological and Immunohistochemical Details in the Biopsy 115 Ilze Strumfa, Janis Vilmanis, Andrejs Vanags, Ervins Vasko, Dzeina Sulte, Zane Simtniece, Arnis Abolins and Janis Gardovskis

  8 Nonalcoholic Fatty Liver Disease: A Pathological View 161 
Joaquín Cabezas, Marta Mayorga and Javier Crespo

  9 Liver Biopsy After Liver Transplantation 189 
Alpna R. Limaye, Lisa R. Dixon and Roberto J. Firpi

Section 3 Non-Invasive Alternatives of Liver Biopsy .

  10 Non-Invasive Evaluation of Liver Steatosis, Fibrosis and 
Cirrhosis in Hepatitis C Virus Infected Patients Using Unidimensional Transient Elastography (Fibroscan®) 209 Monica Lupsor, Horia Stefanescu, Diana Feier and Radu Badea

  11 Computer Image Analysis of Liver Biopsy Specimens in Patients 
with Heroin Abuse and Coinfection (Tuberculosis, HCV, HIV) 235 Ivan B. Tokin, Ivan I. Tokin and Galina F. Filimonova

  12 Future Aspects of Liver Biopsy: From Reality to Mathematical 
Basis of Virtual Microscopy 257 Ludmila Viksna, Ilze Strumfa, Boriss Strumfs, Valda Zalcmane, Andrejs Ivanovs and Valentina Sondore

  13 Real-Time Tissue Elastography and Transient Elastography for 
Evaluation of Hepatic Fibrosis 281 Hiroyasu Morikawa .

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Published by: Unknown - Monday, January 28, 2013


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