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MESOTHELIOMAS – SYNONYMS AND DEFINITION, EPIDEMIOLOGY, ETIOLOGY, PATHOGENESIS, CYTO-HISTOPATHOLOGICAL FEATURES, CLINIC, DIAGNOSIS, TREATMENT, PROGNOSIS

MESOTHELIOMAS

Edited by Alexander Zubritsky .


The problem of tumor diseases originating from the mesothelium covering the pleura,  peritoneum, pericardium and testicular membranes, is of great scientific and practical interest. And in the last decade alone, this problem has taken on an even greater significance within the medical community. This is because in recent years, there has been a significant increase in the mesothelioma morbidity in most of the countries, the peak frequency is expected in 2010-2022 which is attributable with the further industrialization of society. The morbidity and mortality from the mesotheliomas increase among smokers in particular. Currently there is no doubt that the mesothelioma affects the pleura most often, at least - the peritoneum and pericardium, and even more rarely – the testicular membranes; it is mainly encountered in old age with some predominance in males. However, it is observed in young males and even children.
Nevertheless, the etiology and pathogenesis of mesotheliomas are unknown until the end and these issues require of further study using modern methods of investigation.
In addition, the question of mesotheliomas has so far not developed systematically in the literature. As such, it is necessary to the creation of national centers for pathology who could fill the gap (Zubritsky, 2010. Multiple primary tumors. Bibliographical index of Russian and foreign literature. Kalina, ISBN 978-5-212-01122-8, Moscow).
This book has been written by several contributors from around the world – each with considerable, specialist experience and expertise in mesotheliomas. It differs from the previously published texts in that it includes - first and foremost - new advances in therapy of mesotheliomas in the light of the latest literature on the subject. In addition, this book is perhaps one of the very first published about stem cells in mesotheliomas, and provides new and interesting facts regarding the development of mesotheliomas in domestic animals within veterinary practice.
The book covers all aspects of the various types of mesotheliomas in the organ, tissue, cellular and subcellular levels using immunohistochemical, biochemical and molecular research methods in humans, domestic animals and in experimental models. Each of the book's 14 chapters have been grouped under various sections such as: molecular pathogenesis of malignant pleural mesothelioma, stem cells and mesothelioma, radiologic evaluation of malignant pleural and peritoneal mesothelioma, primary malignant pericardial mesothelioma, testicular mesothelioma, para- and intratesticular aspects of malignant mesothelioma, mesothelioma in domestic animals: cytological and anatomopathological aspects, immuno-oncology and immunotherapy, the role of immunotherapy in the treatment of mesothelioma, connexin 43 enhances the cisplatininduced cytotoxicity in mesothelioma cell, cisplatin resistance in malignant pleural mesothelioma, the impact of extracellular low pH on the anti-tumor efficacy against mesothelioma, the central role of surviving in proliferation and apoptosis in malignant pleural mesothelioma, why anti-energetic agents such as citrate or 3-bromopyruvate should be tested as anti-cancer agents: experimental in vitro and in vivo studies.
Many issues are widely covered in mesotheliomas aforementioned monographs. However, despite the fact that rapid developments have increased and dramatically advanced our understanding of mesotheliomas in recent years, it is important to be mindful of the already-significant achievements made in this field to date in order to enable us to fully appreciate the advances that have been- and continue to be made.
In this book an attempt has been made to provide the reader with several insights into the findings of the various authors based on their own individual research. For example, the chapters 1 and 2 are focused on the molecular mechanisms of development of mesotheliomas in light of new ideas, which in future will undoubtedly affect future therapeutic treatment strategy of mesothelioma patients that will in turn provide a powerful capacity for the formulation of the standard systemic treatment of such patients using the new anticancer agents. A retrospective analysis using a computed tomography and magnetic resonance imaging in patients with pleural and peritoneal mesothelioma is presented in chapter 3. Epidemiology, clinical picture, diagnosis, treatment and prognosis in patients with malignant pericardial mesothelioma are summarized in chapter 4. All the aspects of the testicular mesotheliomas with the use of the immunohistochemical markers in chapters 5 and 6 are reflected. Mesotheliomas in domestic animals, investigated at the organ, tissue and cellular levels, and included in the chapter 7, are of an extraordinary interest in termsof veterinary practice and the rarity of such observations. Particular emphasis is placed on the new valuable achievements in the field of cancer therapy and, in particular, of mesotheliomas, as detailed in the last seven chapters that deal with the prospective role of immuno - and chemotherapy using new chemotherapeutic agents in their various combinations in the treatment of mesothelioma patients with positive effect.
The book is designed for a wide range of practical doctors in various specialties and medical students. I should also hope that the publication will be greeted with great interest and will be useful primarily to oncologists in various fields. Finally of this preface I feel it is my duty to express the deep gratitude to all the staff of the Publishing House InTech, and most notably Ms. Ana Nikolic, Head of Editor Care and  Support Department, Mr. Vedran Greblo, Publishing Process Manager, and Mr. Oliver Kurelic, Publishing Process Manager for the persistent business and good relations  and for the technical advisory assistance in the work on the release of this book, as  well as a special thanks to the team of authors who contributed their chapters to share  with readers within the wider medical and scientific community.


Alexander Zubritsky MD, PhD,

Book Editor, Moscow,
Russian Federation
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CONTENTS Of THE TEXTBOOK :


Chapter 1 Molecular Pathogenesis of Malignant 
Pleural Mesothelioma 1 Philip A. Rascoe, Xiaobo X. Cao and W. Roy Smythe

Chapter 2 Stem Cells and Mesothelioma 17 
Bonnie W. Lau

Chapter 3 Radiologic Evaluation of Malignant Pleural 
and Peritoneal Mesothelioma 27 Elif Aktas, Kemal Arda, Bora Aktas, Sahin Coban, Nazan Çiledağ and Bilgin Kadri Aribas

Chapter 4 Primary Malignant Pericardial Mesothelioma 39 Jesus Montesinos, Sílvia Catot, Francesc Sant and Montserrat Domenech

Chapter 5 Testicular Mesothelioma 49 
Alexander N. Zubritsky

Chapter 6 Para- and Intratesticular Aspects of 
Malignant Mesothelioma 71 Zachary Klaassen, Kristopher R. Carlson, Jeffrey R. Lee, Sravan Kuvari and Martha K. Terris

Chapter 7 Mesothelioma in Domestic Animals: 
Cytological and Anatomopathological Aspects 87
Winnie A. Merlo and Adriana S. Rosciani

Chapter 8 Immuno-Oncology and Immunotherapy 97 
R. Cornelissen, J.G.J.V. Aerts and J.P.J.J. Hegmans

Chapter 9 The Role of Immunotherapy in 
the Treatment of Mesothelioma 121 Saly Al-Taei, Jason F. Lester and Zsuzsanna Tabi

Chapter 10 Connexin 43 Enhances the Cisplatin-Induced Cytotoxicity 
in Mesothelioma Cells 153     Hiromi Sato and Koichi Ueno

Chapter 11 Cisplatin Resistance in Malignant Pleural Mesothelioma 169 
Parviz Behnam-Motlagh, Andreas Tyler, Thomas Brännström, Terese Karlsson, Anders Johansson and Kjell Grankvist

Chapter 12 The Impact of Extracellular Low pH on the Anti-Tumor Efficacy Against Mesothelioma 187 T. Fukamachi, H. Saito, M. Tagawa and H. Kobayashi

Chapter 13 The Central Role of Survivin in Proliferation and
Apoptosis of Malignant Pleural Mesothelioma 211 Julija Hmeljak and Andrej Cör

Chapter 14 Why Anti-Energetic Agents Such as Citrate or 3-Bromopyruvate Should be Tested as Anti-Cancer Agents: Experimental In Vitro and In Vivo Studies 225 Philippe Icard, Xiao-Dong Zhang, Emilie Varin, Stéphane Allouche, Antoine Coquerel, Maria Paciencia, Luc Joyeux, Pascal Gauduchon, Hubert Lincet and Laurent Poulain . 





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Published by: younes younes - Wednesday, January 23, 2013

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