Open Access Medical Books


Edited by Anica Dricu .
310 pages .

There is a widespread interest in the today scientific literature for methylation field, which 
started to be published in the early 60’s and continues to be a future line of research. This 
book represents a comprehensively reviewed literature on the importance of methylation 
processes in human health and disease. The book, covers the basic mechanism of DNA and 
protein methylation, along with the role of mRNA cap methylation in viral replication, gene 
expression and viral pathogenesis. Human health risks from metals methylation in the natural 
environment has been well describe in the literature. As a consequence, the formation 
processes, the biotic and abiotic degradation and the accumulation of the methylated metals 
and metalloids in the aquatic environment is reviwed in the book.
DNA methylation is a well-characterized process, allowing cells to control gene expression, 
while the study of histone methylation is more recent. The enzymes responsible for histone 
methylation (histone methyltransferases and histone demethylases) are important for transcriptional 
regulation in both normal and abnormal states, representing an important target 
for drug discovery. The interconection between DNA methylation and other regulatory molecules 
such as: enzymes, transcription factors, proteins and growth factors is discussed, providing 
key information about the mechanisms that trigger cell proliferation, differentiation, 
aging and malignant transformation. This textbook strongly point out the importance of methylated 
DNA as a biological marker of cancer an also gives the reader insights into the recently 
emerged treatment modalities targeting methylation mechanism, in various diseases 
including cancer.
The textbook addresses the following topics: Gene expression and methylation, DNA-methyltransferases: 
structure and function in eukaryotic and prokaryotic system; Protein arginine
methylation in mammals; Cancer research through study of methylation cell processes; Bacteria, 
viruses and metals methylation: risk and benefit for human health.
The book aims at the advanced undergraduate and graduate biomedical students and researchers 
working in the epigenetic area, providing readers with both classical and relevant 
recent discoveries that have been made in the research field of methylation and also pointing 
out pathways where questions remain.

Prof. Anica Dricu
University of Medicine and Pharmacy
Faculty of Medicine
Craiova, Romania


Section 1 Gene Expression and Methylation 1

Chapter 1 Breaking the Silence: The Interplay Between Transcription 
Factors and DNA Methylation 3
Byron Baron

Section 2 DNA-Methyltransferases: Structure and Function in Eukaryotic and Prokaryotic System 27

Chapter 2 Diverse Domains of (Cytosine-5)-DNA Methyltransferases: 
Structural and Functional Characterization 29
A. Yu. Ryazanova, L. A. Abrosimova, T. S. Oretskaya and E. A. Kubareva

Chapter 3 Bifunctional Prokaryotic DNA-Methyltransferases 71
Dmitry V. Nikitin, Attila Kertesz-Farkas, Alexander S. Solonin and Marina L. Mokrishcheva

Section 3 Protein Arginine Methylation in Mammals 89

Chapter 4 Deciphering Protein Arginine Methylation in Mammals 91
Ruben Esse, Paula Leandro, Isabel Rivera, Isabel Tavares de Almeida, Henk J Blom and Rita Castro

Section 4 Cancer Research Through Study of Methylation Cell Processes 117

Chapter 5 Methylation in Tumorigenesis 119
Melissa A. Edwards, Pashayar P. Lookian, Drew R. Neavin and Mark A. Brown

Chapter 6 Circulating Methylated DNA as Biomarkers for Cancer 
Detection 137
Hongchuan Jin, Yanning Ma, Qi Shen and Xian Wang

Chapter 7 DNA Methylation, Stem Cells and Cancer 153
Anica Dricu, Stefana Oana Purcaru, Alice Sandra Buteica, Daniela Elise Tache, Oana Daianu, Bogdan Stoleru, Amelia Mihaela
Dobrescu, Tiberiu Daianu and Ligia Gabriela Tataranu

Chapter 8 DNA Methylation in the Pathogenesis of Head and 
Neck Cancer 185
Zvonko Magić, Gordana Supić, Mirjana Branković-Magić and Nebojša Jović

Section 5 Bacteria, Viruses and Metals Methylation: Risk and Benefit for Human Health 217

Chapter 9 Host-Mimicking Strategies in DNA Methylation for Improved 
Bacterial Transformation 219
Hirokazu Suzuki

Chapter 10 Messenger RNA Cap Methylation in Vesicular Stomatitis Virus, 
a Prototype of Non Segmented Negative‐Sense RNA Virus 237
Jianrong Li and Yu Zhang

Chapter 11 The Methylation of Metals and Metalloids in 
Aquatic Systems 271
Robert P. Mason .

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Published by: Unknown - Tuesday, January 29, 2013


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