Open Access Medical Books


Edited by Tomasz Brzozowski .

The purpose of writing this book was to overview recent hot topics in 
gastroenterology with a focus directed towards information derived from the bench 
and used at the patient's bedside. To address these issues, scientists who are working 
on a daily basis in the field of experimental gastroenterology and clinical investigators, 
with their chapter proposal's being peer-reviewed, all have integrated their attempts to 
summarize the recent advances in the pathophysiology and therapy of upper and 
lower gastrointestinal tract disorders. Such an integrative approach in basic and 
clinical gastroenterology seems to be essential for the pathomechanism, proper 
diagnosis and management of patients who suffer from gastrointestinal disorders. The 
potential reader will not only find in this book the recent advances in the physiology
and pathomechanism of GI tract disorders, but also the treatment options based on 
pharmacological and surgical intervention and the recent advances in the biological 
therapy with probiotics and prebiotics, which nowadays is a rapidly growing area of 
interest. For instance, Betta and Vitaliti described in their review, the direct and indirect 
effects of probiotics in the functional interactions between bacteria, gut epithelium, gut 
mucosal immune system and systemic immune system. The direct effect of probiotics 
in the lumen include the competition with pathogens for nutrients, production of 
antimicrobial substances and in particular organic acids competitive inhibition on the 
receptor sites, change in the composition of mucin hydrolysis of toxins, receptor
hydrolysis, and nitric oxide (NO). The indirect effect of probiotics largely depends on 
the site of interaction between the probiotic and the effectors of the immune response.
Thantasha et al., presented the number of specific properties or criteria a microbial 
strain has to fulfill in order for it to be regarded as a probiotic. These criteria are 
classified into its safety profile, performance within the GI tract and technological 
aspects of its development. The criteria are further dependent on the specific purpose 
of the strain and on the location for the expression of the specific property. With 
regards to safety, the probiotic strain must be of human origin, isolated from the 
gastrointestinal tract (GIT) of healthy individuals. The strain itself, its fermentation 
products or its cell components after its death, should be non-pathogenic, non-toxic,
non-allergic, non-mutagenic or non-carcinogenic even when given to 
immunocompromised individuals. The detailed criteria for the probiotic is underlined 
with respect to their performance, acid-tolerance and survival in the human gastric 
juices and bile. Probiotic bacteria must be able to survive in sufficient numbers and 
adhere to the intestinal mucosal surface in order to survive within the gastrointestinal 
tract. .......

Tomasz Brzozowski
Professor of Medicine, Chairman, Department of Physiology,
Jagiellonian University Medical College, Cracow


Section 1 Emerging Impact of Probiotics in Gastroenterology 1

Chapter 1 Intestinal Microbial Flora – 
Effect of Probiotics in Newborns 3
Pasqua Betta and Giovanna Vitaliti

Chapter 2 Probiotics – What They Are, 
Their Benefits and Challenges 21
M.S. Thantsha, C.I. Mamvura and J. Booyens

Chapter 3 The Impact of Probiotics 
on the Gastrointestinal Physiology 51
Erdal Matur and Evren Eraslan

Chapter 4 The Benefits of Probiotics in Human and Animal Nutrition 75
Camila Boaventura, Rafael Azevedo, Ana Uetanabaro, Jacques Nicoli and Luis Gustavo Braga

Chapter 5 Gut Microbiota in Disease Diagnostics 101
Knut Rudi and Morten Isaksen

Chapter 6 Delivery of Probiotic Microorganisms 
into Gastrointestinal Tract by Food Products 121
Amir Mohammad Mortazavian, Reza Mohammadi and Sara Sohrabvandi

Section 2 Pathomechanism and Management of the Upper Gastrointestinal Tract Disorders 147

Chapter 7 Chronic NSAIDs Therapy and Upper Gastrointestinal Tract – 
Mechanism of Injury, Mucosal Defense, Risk Factors for Complication Development and Clinical Management 149
Francesco Azzaroli, Andrea Lisotti, Claudio Calvanese, Laura Turco and Giuseppe Mazzella

Chapter 8 Swallowing Disorders 
Related to Vertebrogenic Dysfunctions 175
Eva Vanaskova, Jiri Dolina and Ales Hep

Chapter 9 Enhanced Ulcer Recognition from 
Capsule Endoscopic Images Using Texture Analysis 185
Vasileios Charisis, Leontios Hadjileontiadis and George Sergiadis

Chapter 10 Methods of Protein Digestive Stability Assay – State of the Art 211
Mikhail Akimov and Vladimir Bezuglov

Chapter 11 Mesenteric Vascular Disease 235
Amer Jomha and Markus Schmidt

Chapter 12 A Case Based Approach to 
Severe Microcytic Anemia in Children 247
Andrew S. Freiberg

Section 3 Pathophysiology and Treatment of Pancreatic and Intestinal Disorders 267

Chapter 13 Emerging Approaches for the 
Treatment of Fat Malabsorption Due to Exocrine Pancreatic Insufficiency 269
Saoussen Turki and Héla Kallel

Chapter 14 Pharmacology of Traditional Herbal 
Medicines and Their Active Principles Used in the Treatment of Peptic Ulcer, Diarrhoea and Inflammatory Bowel Disease 297
Bhavani Prasad Kota, Aik Wei Teoh and Basil D. Roufogalis

Chapter 15 Evaluating Lymphoma Risk in 
Inflammatory Bowel Disease 311
Neeraj Prasad

Chapter 16 Development, Optimization and 
Absorption Mechanism of DHP107, Oral Paclitaxel
Formulation for Single-Agent Anticancer Therapy 357
In-Hyun Lee, Jung Wan Hong, Yura Jang, Yeong Taek Park and Hesson Chung

Chapter 17 Differences in the Development of the Small Intestine 
Between Gnotobiotic and Conventionally Bred Piglets 375
Soňa Gancarčíková

Chapter 18 Superior Mesenteric Artery Syndrome 415
Rani Sophia and Waseem Ahmad Bashir

Chapter 19 Appendiceal MALT Lymphoma in 
Childhood – Presentation and Evolution 419
Antonio Marte, Gianpaolo Marte, Lucia Pintozzi and Pio Parmeggiani

Chapter 20 The Surgical Management of Chronic Pancreatitis 429
S. Burmeister, P.C. Bornman, J.E.J. Krige and S.R. Thomson

Chapter 21 The Influence of Colonic Irrigation 
on Human Intestinal Microbiota 449
Yoko Uchiyama-Tanaka

Section 4 Diseases of the Liver and Biliary Tract 459

Chapter 22 Pancreato-Biliary Cancers – 
Diagnosis and Management 461
Nam Q. Nguyen

Chapter 23 Recontructive Biliary Surgery in the 
Treatment of Iatrogenic Bile Duct Injuries 477
Beata Jabłońska and Paweł Lampe

Chapter 24 Hepatic Encephalopathy 495 
Om Parkash, Adil Aub and Saeed Hamid

Chapter 25 Adverse Reactions and Gastrointestinal Tract 511
A. Lorenzo Hernández, E. Ramirez and Jf. Sánchez Muñoz-Torrero

Chapter 26 Selected Algorithms of Computational 
Intelligence in Gastric Cancer Decision Making 529
Elisabeth Rakus-Andersson .

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Published by: Unknown - Monday, January 28, 2013


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