Open Access Medical Books


Edited by Ayman Noreddin .
388 pages .

Despite the increasing attention on the topic of pharmacokinetics our understanding of 
advanced concepts and its applications in drug development remains limited. The 
intention of this book is to bridge the theory-practice gap by providing advanced 
pharmacokinetics concepts, methods, and applications. Graduate students as well as 
scientists in the area of clinical pharmacology and pharmacokinetics will find the 
contents of this book very enlightening and helpfull. The comprehensive coverage of 
topics on pharmacokinetics in this book offers readers “à la carte” choice to build their 
knowledge based on their scientific needs.
I would like to personally thank all the authors for their excellent contributions to the 
book. These researchers are at the forefront of innovation in pharmacokinetics and its 
application to the clinical science and to drug development.

Ayman Noreddin MS, PhD, RPh
ssociate Professor and Chair, Department of Pharmacy Practice,
School of Pharmacy, Hampton University


Section 1 Advanced Concepts 1

Chapter 1 Bioequivalence Studies 3
Aisha Qayyum

Chapter 2 Computer Simulations as a Tool 
for Optimizing Bioequivalence Trials 17
Carmen Navarro-Fontestad,Victor Mangas-Sanjuán, Isabel González-Álvarez, Alfredo García-Arieta, Carlos Fernández-Teruel, Vicente G. Casabó-Alós and Marival Bermejo

Chapter 3 Evaluation of Percutaneous Drug 
Permeation Using a Lateral Sectioning Approach 35
Nobuhiro Goi, Katsunori Morishita, Akihito Taniguchi and Takayuki Ishii

Chapter 4 Pharmacogenomics Dictate 
Pharmacokinetics: Polymorphisms in Drug-Metabolizing Enzymes and Drug-Transporters 55
Debasis Mondal, Samantha L. Gerlach, Amrita Datta, Geetika Chakravarty and Asim B. Abdel-Mageed

Chapter 5 Genetic Variation in Drug Disposition 101
Balmukunda Regmi and Laxman Bharati

Chapter 6 Application of Pharmacokinetics/Pharmacodynamics (PK/PD) 
in Designing Effective Antibiotic Treatment Regimens 111
Ghada F. Ahmed and Ayman M. Noreddin

Chapter 7 Pharmacokinetics and Drug 
Interactions of Herbal Medicines: A Missing Critical Step in the Phytomedicine/Drug Development Process 127
Obiageri O. Obodozie

Chapter 8 Pharmacokinetics of Antimicrobials in Food Producing Animals 157
S. K. Bhavsar and A. M. Thaker

Chapter 9 Comparative Veterinary Pharmacokinetics 179
Akos Jerzsele

Section 2 Methods and Applications 199

Chapter 10 Observer-Based Strategies for 
Anesthesia Drug Concentration Estimation 201
Jin-Oh Hahn, Guy A. Dumont and J. Mark Ansermino

Chapter 11 Optimal Pharmacokinetics 
of Cyclosporine and Tacrolimus Based Relationship Among AUC, Trough and Peak Concentration 217
Hironori Takeuchi

Chapter 12 Pharmacokinetics and Metabolized 
Caroteniods in Liver of Single Dose Administration in Fancy Carp (Cyprinus carpio) 237
Bundit Yuangsoi

Chapter 13 Correlation of in vitro Dissolution 
Profiles with in vivo Pharmacokinetic
Parameters of Some Commercial Brands of Aspirin Tablets Marketed in Nigeria 251
Emmanuel Adelaja Bamigbola

Chapter 14 Bioavailability of Citrus 
Polymethoxylated Flavones and Their Biological Role in Metabolic Syndrome and Hyperlipidemia 267
Malkanthi Evans, Prachi Sharma and Najla Guthrie

Chapter 15 Role of Aldehyde Oxidase and Xanthine 
Oxidase in the Metabolism of Purine-Related Drugs 285
Mohammad-Reza Rashidi and Roghiyeh Pashaei-Asl

Chapter 16 Pharmacokinetic/Pharmacodynamic 
(PK/PD) Modeling of Anti-Neoplastic Agents 315
Daniel Lexcen, Ahmed Salem, Walid M. El-Khatib, Virginia Haynes and Ayman Noreddin

Chapter 17 Pharmacokinetic (PK) and 
Pharmacodynamic Profiles of Artemisinin
Derivatives Influence Drug Neurotoxicity in Animals 323
Qigui Li and Mark Hickman
Chapter 18 One Step Closer to the Target: Intracellular Pharmacokinetics of Gemcitabine 357
Matthew Links and Peter Galettis .

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Published by: Unknown - Tuesday, January 29, 2013


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