Open Access Medical Books



Edited by Ali Demir Sezer .

512 pages . 
Open Access .

Drug delivery is a method or process of administering a pharmaceutical compound to  achieve a therapeutic effect in humans or animals. Drug delivery technologies modify  drug release profile, absorption, distribution and elimination for the benefit of  improving product efficacy and safety, as well as patient convenience and compliance.

Drug release comes from diffusion, degradation, swelling, and affinity-based  mechanisms. Most common routes of administration include the preferred noninvasive  peroral, topical, transmucosal and inhalation routes. Many medications such  as peptide and protein, antibody, vaccine and gene based drugs, in general may not be  delivered using these routes.
However, for all these exciting new drug and vaccine candidates, it is necessary to  develop suitable dosage forms or drug delivery systems to allow the effective, safe and  reliable application of these bioactive compounds to the patient. In the view of most  experts pharmacology is on drugs, targets, and actions. In the context, the drug as a  rule is seen as an active pharmaceutical ingredient and not as a complex mixture of  chemical entities of a well defined structure. Today, we are becoming more and more  aware of the fact that delivery of the active compound to the target site is a key. The  present volume gives a topical overview on various modern approaches to drug delivery and targeting on covering today’s options for specific carrier systems  allowing successful drug treatment at various sites of the body that are difficult to  address and allowing to increase the benefit-risk-ratio to the optimum.
On the other hand, the reader will be introduced to various aspects of the  fundamentals of nanotechnology based drug delivery systems and the application of  these systems for the delivery of small molecules, proteins, peptides, oligonucleotides  and genes. How these systems overcome challenges offered by biological barriers to  drug absorption and drug targeting will also be described.
The aim of this book was to gather all results coming from very fundamental studies.
Again, this allows to gain a more general view of the various drug carrier systems and  can prepare and apply, along with the methodologies necessary to design, develop  and characterize them.
It is critical for the field of drug delivery from a proof of concept to a pharmaceutical  product at the beginning of the new millennium. A successful outcome will result in a  new clinical modality that represents a revolutionary approach to medicine. One  immediate benefit will be to produce a continuous level of therapeutic protein,  avoiding the characteristic peak and trough behavior of intermittent administrations  with drug carrier systems. Novel drug delivery carriers will have the capability to turn  genes on or off on demand, producing a therapy that can treat the disease rather than  the symptoms and with minimal side effects.

Ali Demir Sezer

Faculty of Pharmacy
Dept. of Pharmaceutical Biotechnology
Marmara University


Section 1 Powder Technology in Drug Delivery 

  1 Hot-Melt Extrusion (HME): 
From Process to Pharmaceutical Applications 3 Mohammed Maniruzzaman, Dennis Douroumis, Joshua S. Boateng and Martin J. Snowden

  2 Development and Investigation of Dry 
Powder Inhalers for Cystic Fibrosis 17 Paola Russo, Antonietta Santoro, Lucia Prota, Mariateresa Stigliani and Rita P. Aquino

  The Role of Carrier in Dry Powder Inhaler 39 
Hamed Hamishehkar, Yahya Rahimpour and Yousef Javadzadeh

Section 2 Nanocarriers in Drug Delivery 

  Nanotechnology in Drug Delivery 69 
Martins Ochubiojo Emeje, Ifeoma Chinwude Obidike, Ekaete Ibanga Akpabio and Sabinus Ifianyi Ofoefule
 Chapter 5 Lipid Nanoparticulate Drug Delivery Systems: A Revolution in Dosage Form Design and Development 107 Anthony A. Attama, Mumuni A. Momoh and Philip F. Builders

  Niosomes as Carrier in Dermal Drug Delivery 141 
Yahya Rahimpour and Hamed Hamishehkar

 7 Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery 165 Seyda Bucak, Banu Yavuztürk and Ali Demir Sezer

  8 Nanocarrier Systems for Transdermal Drug Delivery 201 José Juan Escobar-Chávez, Isabel Marlen Rodríguez-Cruz, Clara Luisa Domínguez-Delgado, Roberto Díaz- Torres, Alma Luisa Revilla-Vázquez, Norma Casas Aléncaster

  9 Targeted Nanoparticles for Cancer Therapy 241 
M.D. Blanco, C. Teijón, R.M. Olmo and J.M. Teijón

Section 3 Miscellaneous 

  10 Oral Delivery of Insulin: Novel Approaches 281 
Amani M. Elsayed

  11 Novel Mucoadhesive Polymers for Nasal Drug Delivery 315 Utkarshini Anand, Tiam Feridooni and Remigius U. Agu

  12 Amphiphilic Cyclodextrins, Synthesis, Utilities and 
Application of Molecular Modeling in Their Design 331 Atena Jabbari and Hamid Sadeghian

  13 Processing and Templating of Bioactive-Loaded 
Polymeric Neural Architectures: Challenges and Innovative Strategies 355 Viness Pillay, Pradeep Kumar, Yahya E. Choonara, Girish Modi, Dinesh Naidoo and Lisa C. du Toit

  14 Novel Drug Delivery Systems for Modulation of 
Gastrointestinal Transit Time 393 Yousef Javadzadeh and Sanaz Hamedeyazdan

  15 Advanced Drug Carriers Targeting Bone Marrow 419 
Keitaro Sou

  16 Gene Delivery Systems: Recent Progress 
in Viral and Non-Viral Therapy 437 Erdal Cevher, Ali Demir Sezer and Emre Şefik Çağlar

  17 Is Chronic Combination Therapy of HAART and α-ZAM, Herbal Preparation for HIV Infection Safe? 471
 A. A. Onifade, B.H. Olaseinde and T. Mokowgu

  18 Nanoparticles Toxicity and Their Routes of Exposures 483 Ahmet Aydın, Hande Sipahi and Mohammad Charehsaz .

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Published by: Unknown - Monday, January 28, 2013


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