Open Access Medical Books

RETINOBLASTOMA – AN UPDATE ON CLINICAL, GENETIC COUNSELING, EPIDEMIOLOGY AND MOLECULAR TUMOR BIOLOGY

RETINOBLASTOMA
Edited by Govindasamy Kumaramanickavel .

Retinoblastoma is the first ever discovered tumor suppressor gene that opened a new  avenue in the field of oncology leading to the identification of 35 tumor suppressor  
genes, till date in our genome. It is four decades since we know the two-hit hypotheses 
of Dr Alfred G Knudson and presently there is a huge amount of data available for us 
to completely comprehend the retinoblastoma gene and protein. However this reveals 
that there is more to learn and understand about its character and characteristics.

This book is an excellent compilation of both clinical and basic science information that 
meets the needs of a young clinician and a researcher at the same time. It also has 
abundant information on recent advances and cutting-edge knowledge in intracellular 
molecular cross-talking of retinoblastoma protein with various cellular viral-like proteins.

Looking into the details of this book, you will find that there is an excellent clinical 
description of the disease with adequate illustrations. The dreadful problem of second 
malignancies both ocular and non-ocular is dealt with elegantly. The ototoxic hearing 
loss in retinoblastoma patients provides greater insight into the disease, which would 
be a useful tool for practicing clinicians. For all levels of clinicians, whether entry, mid 
or senior, there is information on the genetic counseling and molecular diagnostics 
which are very useful. The epidemiology of retinoblastoma is a revelation for those 
both in clinics and research.

In understanding the molecular tumor biology of the disease, the role of RB protein in 
cell growth and tumor progression is extensively described. Interestingly a little 
known role of RB protein in the survival and differentiation of cerebellar neurons is 
discussed in great detail. The role of viral oncogenes and retinoblastoma family 
proteins is an exciting area that is teased out. The genetics of retinoblastoma is 
described quite elaborately as well.




Dr. Govindasamy Kumaramanickavel
Research Director, Narayana Nethralaya, Bangalore,
Advisor - Research, Academics and Management, Aditya Jyot Eye Hospital, Mumbai
India
Visiting Associate, Ophthalmic Genetics and Clinical Services Branch,
National Eye Institute, NIH
USA

CONTENTS :


Part 1 Clinical Sciences 1


Chapter 1 Review of Clinical Presentations of Retinoblastoma 3
Onyekonwu Chijioke Godson

Chapter 2 Second Malignancies in Retinoblastoma: The Real Problem 23
Basil K. Williams Jr. and Amy C. Schefler

Chapter 3 Ototoxic Hearing Loss and Retinoblastoma Patients 39
Shaum P. Bhagat

Chapter 4 Retinoblastoma – Genetic Counseling and Molecular Diagnosis 55
Claude Houdayer, Marion Gauthier-Villars, Laurent Castéra, Laurence Desjardins,
François Doz and Dominique Stoppa-Lyonnet


Part 2 Epidemiology 73


Chapter 5 Epidemiology of Retinoblastoma 75
Wilson O. Akhiwu and Alex P. Igbe

Part 3 Basic Sciences 83


Chapter 6 The Retinoblastoma Family Protein p130 as a Negative Regulator of Cell Growth and Tumor Progression 85
Luigi Bagella

Chapter 7 Significance of 
Retinoblastoma Protein in Survival and Differentiation of Cerebellar Neurons 109
Jaya Padmanabhan

Chapter 8 Cytoskeletal Organization and Rb Tumor Suppressor Gene 131
Yi-Jang Lee, Pei-Hsun Chiang
and Peter C. Keng

Chapter 9 Viral Oncogenes and the Retinoblastoma Family 155
M. Geletu and L. Raptis .


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Published by: younes younes - Saturday, January 26, 2013

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