Open Access Medical Books



Edited by Ricardo Fernandez .

Open Access .
Sepsis has been defined as a serious condition in which there is a systemic inflammation secondary to an infectious process. This can progress to a level at which it results in a complex disorder, leading to multiple organ failure and eventually death. Although it has been well recognized as one of the top killers worldwide, its   incidence continues to rise dramatically with some studies showing approximately  1,400 daily deaths.
Some experts usually consider sepsis as one of the most challenging conditions  because of its multiple presentations and the variety of its complications.
Since severe sepsis/septic shock is one of the leading causes of intensive care units  admissions, the costs are overwhelming . There is no doubt that the development and  implementation of standards of care should help provide an adequate management  and improve the patient’s outcome.
For instance, various investigators from all over the world got their chance, in this  book, to provide important information regarding this deadly disease .
The chapters of this book have been guided by numerous references designed to  understand the mechanism, consequences and recommended therapies for severe  sepsis and septic shock.
The book is divided in multiple sections in order to study all of the aspects of sepsis  and fulfil the readers‘ interest in this condition.
We hope that the efforts of these investigators will result in a useful way to not only  create consciousness of early diagnosis and treatment, but also to continue with  intense work and interest for the care of our patients.
We also want to appreciate the assistance of the publishing manager and all of the  people that collaborated with the book.
Finally, I personally want to congratulate all of the authors for their contributions.

Dr Ricardo Fernandez Gonzalez, FCCP

American College of Chest Physician
American College of Critical Care Medicine
American Thoracic Society
Pulmonary Training Program San Juan City Hospital
Puerto Rico


Part 1 Definition and Epidemiology 

Chapter 1 Epidemiology of Severe Sepsis and Septic Shock 3 
Arturo Artero, Rafael Zaragoza and José Miguel Nogueira

Part 2 Etiology 

Chapter 2 Septic Shock by Gram-Negative Infections: 
Role of Outer Membrane Proteins 27 Marilena Galdiero, Marco Cantisani, Rossella Tarallo, Annarita Falanga and Stefania Galdiero

Chapter 3 Transfusion-Associated Bacterial Sepsis 47 
Jolanta Korsak

Part 3 Pathological Findings 

Chapter 4 The Autopsy Pathology of Sepsis-Related Death 71 Sebastian Lucas

Part 4 Pathophysiology 

Chapter 5 Biomarkers and Physiological Agents in
Severe Sepsis and Septic Shock 103 D. Paramythiotis, E. Digkas and G. Dryllis

Chapter 6 Immune Cell Dysfunction as a 
Consequence of Severe Sepsis 125 William F. Carson IV and Steven L. Kunkel

Chapter 7 Microparticles and Exosomes: Are They Part of Important Pathways in Sepsis Pathophysiology? 1
55 Luciano C. P. Azevedo

Chapter 8 Cellular Mechanisms of MOF During Severe Sepsis and Septic Shock 167 Barbara Assenzio and Erica L. Martin-Conte

Chapter 9 Impact of Severe Sepsis or 
Septic Shock on Drug Response 187 Marta Vázquez, Pietro Fagiolino, Cecilia Maldonado, Manuel Ibarra and Anna Boronat

Part 5 Management 

Chapter 10 Update in the Treatment of 
Severe Sepsis and Septic Shock 203 D. Boodoosingh, C. Cruz, M. Egozcue, R. Fernandez, V. Salinas and S. Valentin

Chapter 11 Management of Severe Sepsis and Septic Shock 227 
Georges Samaha, Brian Casserly and John-Michael Stevens

Chapter 12 Applied Physiology and the Hemodynamic 
Management of Septic Shock Utilizing the Physiologic Optimization Program 255 William McGee and Patrick Mailloux

Part 6 Pediatric Sepsis 

Chapter 13 Management of Septic Shock in Children 275 
Martin C. J. Kneyber

Chapter 14 Septic Shock in Neonates 285 Lidia Decembrino ,Giulia Ruffinazzi, Armando D’Angelo, Nunzia Decembrino, Paolo Manzoni, Agata Boncimino and Mauro Stronati

Part 7 Septic Shock in Obstetrics and Gynecology 

Chapter 15 Septic Shock in Obstetrics and Gynecology 311 
Apostolos Kaponis, Theodoros Filindris and George Decavalas

Part 8 Novel and Alternative Therapies 

Chapter 16 Alternative Therapies for Septic Shock: Beyond Early Goal-Directed Therapy 337
 Megan Rech, Megan Prasse and Payal Gurnani

Chapter 17 Hormonal Therapies in Severe Sepsis 359
Karen Choong Chapter 18 Anti Inflammatory Role of Natural Polyphenols and Their Degradation Products 379 Balázs Veres

Part 9 Outcomes 

Chapter 19 Cellular and Molecular 
Markers of Outcome in Septic Shock 413 Jorge Monserrat, Raúl de Pablo, David Díaz, Miguel-Angel Sánchez, Eduardo Reyes, Alfredo Prieto and Melchor Álvarez de Mon .

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Published by: Unknown - Sunday, January 27, 2013


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