Open Access Medical Books

STEROIDS - FROM PHYSIOLOGY TO CLINICAL MEDICINE

STEROIDS structural formula
Edited by Sergej M. Ostojic .

Understanding complex mechanisms of action and key roles in different biological processes 
in the body has moved steroid science and medicine to expand rapidly in the past decades.
Dozens of distinct steroids are identified as both control and target molecules, with 
regulation of physiological and pathophysiological steroidogenesis recognized as one of the 
essential research topics in the field. On the other hand, steroids have been practiced as both 
medical agents and clinical markers for many purposes, from bone marrow stimulation to 
growth monitoring. This book covers contemporary basic science on steroid research, along 
with steroid practical application in endocrinology and clinical medicine.
The book is divided in two parts. The first part deals with physiological and 
pathophysiological roles of steroids, with reference to production and action of gonadal 
steroids, role of steroid sulfonation in mammalian growth and development, sex specific 
and steroids-dependent mechanism of hippocampal function, and the importance of 
hydroxysteroid dehydrogenases for the modulation of tissue glucocorticoid availability. The 
second part will cover different aspects of steroids application in clinical environment. 
Topics covered in the second part include the endocrine function after ovarian 
transplantation in terms of sex steroid production from the cryopreserved and reimplanted 
ovaries, the diagnostic significance of collection, storage and measurement of androgens in 
saliva of females, main drawbacks of steroids use in sport and exercise, analysis of serum 
steroid hormone profiles in patients with adrenocortical tumors, and correlation between 
salivary and serum cortisol responses after alcohol intake.
In response to the need to address novel and valuable information on steroids science and 
medicine, we sincerely hope that this book will enable readers to comprehend this fastgrowing 
and exciting scientific field.

Sergej M. Ostojic, MD, PhD
Professor of Biomedical Sciences in Sport & Exercise
Center for Health, Exercise and Sport Sciences, Belgrade
Faculty of Sport and Physical Education, University of Novi Sad
Serbia

CONTENTS :

Section 1 Physiology and Pathophysiology of Steroids 1

Chapter 1 Gonadal Sex Steroids: Production, Action and Interactions in Mammals 3
Zulma Tatiana Ruiz-Cortés

Chapter 2 The Biological Roles of Steroid Sulfonation 45
Paul Anthony Dawson

Chapter 3 Hippocampal Function and Gonadal Steroids 65
Dai Mitsushima

Chapter 4 11β-Hydroxysteroid Dehydrogenases in the Regulation of
Tissue Glucocorticoid Availability 83
Cidália Pereira, Rosário Monteiro, Miguel Constância and Maria João Martins

Section 2 Steroids: Clinical Application 107

Chapter 5 Sex Steroid Production from Cryopreserved and Reimplanted Ovarian Tissue 109
Sanghoon Lee and Seung-Yup Ku

Chapter 6 Female Salivary Testosterone: Measurement, Challenges and Applications 129
E.A.S. Al-DujailI and M.A. Sharp

Chapter 7 Limits of Anabolic Steroids Application in Sport and Exercise 169
Marko D. Stojanovic and Sergej M. Ostojic

Chapter 8 Steroidogenic Enzyme 17,20-Lyase Activity in Cortisolsecreting and Non-Functioning Adrenocortical Adenomas 187
Hajime Ueshiba

Chapter 9 Salivary or Serum Cortisol: Possible Implications for Alcohol Research 199
Anna Kokavec



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