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TRENDS IN ALCOHOLIC LIVER DISEASE RESEARCH – CLINICAL AND SCIENTIFIC ASPECTS

 ALCOHOLIC LIVER DISEASE
Edited by Ichiro Shimizu .

In most Western countries, alcoholic beverages contribute significantly to a person's 
overall caloric intake. Of greater significance is it's status as the most widely used drug 
worldwide and addictive properties in addition to the damage it causes to various 
organs within the human body - in particular the liver. Alcoholic liver disease occurs 
after prolonged heavy drinking, especially among persons who are physically
dependent on alcohol. Not everyone who drinks alcohol to excess develops serious 
forms of alcoholic liver disease. It is likely that genetic factors determine this 
individual susceptibility, and a family history of chronic liver disease may indicate a 
higher risk. Other factors include being overweight (similar to hepatitis C and nonalcoholic 
fatty liver disease), and iron overload. Women are more susceptible to 
alcoholic liver disease than men, partly because of differences in the rate of alcohol
metabolism, but also for other biological reasons. Alcoholic liver disease encompasses 
a broad spectrum of diseases, ranging from steatosis (fatty liver), steatohepatitis, 
fibrosis, and cirrhosis, to hepatocellular carcinoma.
There have been major advances in our understanding of the liver, and a growing 
number of mechanisms underlying alcoholic liver disease continue to pose new 
challenges. This book presents state-of-the-art information summarizing the current 
understanding of a range of alcoholic liver diseases. Additionally, key cellular, 
biochemical, immunological and microstructural mechanisms, and diagnostic and 
therapeutic advances are also reviewed.
The book constitutes a collection of selected clinical and scientific topics. Some 
chapters treat the cellular, biochemical, immunological, and micro-structural 
mechanisms underlying alcoholic liver diseases. Some other chapters focus on clinical 
alcoholic liver disease pathophysiology, related diagnostics, and therapeutic insights.
Each of the eleven chapters is followed by a detailed bibliography, enabling the reader 
to work in depth on specific topics. Collectively, this book represents a broad range of 
important updated topics.
It is hoped that the target readers, such as hepatologists, clinicians, researchers and 
academicians, will be afforded new ideas and exposed to subjects which extend 
beyond their own scientific disciplines. In addition, students and all those who wish to 
increase their knowledge of advances in the field of alcoholic liver disease will find 
this book a valuable source of information.
My thanks are extended to the authors, the publisher, and most importantly, my 
family.

Ichiro Shimizu, MD, AGAF
Showa Clinic, Kohoku-ku, Yokohama,
Kanagawa, Japan

CONTENTS :

Chapter 1 Alcohol Drinking Patterns and 
Nutrition in Alcoholic Liver Disease 1
Sabine Wagnerberger, Giridhar Kanuri and Ina Bergheim

Chapter 2 Gender Difference in Alcoholic Liver Disease 23
Ichiro Shimizu, Mari Kamochi, Hideshi Yoshikawa and Yoshiyuki Nakayama

Chapter 3 Innate Immunity in Alcohol Liver Disease 41
João-Bruno Soares and Pedro Pimentel-Nunes

Chapter 4 Endothelial Markers and Fibrosis in Alcoholic Hepatitis 65
Roxana Popescu, Doina Verdes, Nicoleta Filimon, Marioara Cornianu and Despina Maria Bordean

Chapter 5 Ethanol-Induced Mitochondrial 
Induction of Cell Death-Pathways Explored 79
Harish Chinna Konda Chandramoorthy, Karthik Mallilankaraman and Muniswamy Madesh

Chapter 6 Cellular Signaling Pathways 
in Alcoholic Liver Disease 91
Pranoti Mandrekar and Aditya Ambade

Chapter 7 Alcoholic Liver Disease and the Survival 
Response of the Hepatocyte Growth Factor 113
Luis E. Gómez-Quiroz, Deidry B. Cuevas-Bahena, Verónica Souza, Leticia Bucio
and María Concepción Gutierrez Ruiz

Chapter 8 Hepatic Myofibroblasts in Liver Fibrogenesis 129
Chiara Busletta, Erica Novo, Stefania Cannito, Claudia Paternostro and Maurizio Parola

Chapter 9 Up-to-Date Insight About Membrane 
Remodeling as a Mechanism of Action
for Ethanol-Induced Liver Toxicity 159
Odile Sergent, Fatiha Djoudi-Aliche and Dominique Lagadic-Gossmann

Chapter 10 Crucial Role of ADAMTS13 Related to Endotoxemia 
and Subsequent Cytokinemia in the Progression of Alcoholic Hepatitis 179
Masahito Uemura, Yoshihiro Fujimura, Tomomi Matsuyama, Masanori Matsumoto, Hiroaki Takaya, Chie Morioka and Hiroshi Fukui

Chapter 11 The Role of Liver Transplantation in 
theTreatment of Alcoholic Liver Disease 205
Georgios Tsoulfas and Polyxeni Agorastou . 


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