Open Access Medical Books


Edited by Hossein Babaei .

Hypertension or high blood pressure is widely prevalent and a major risk factor for 
cardiovascular diseases including coronary heart disease, myocardial infarction and 
stroke, and frequently causes damage to the arterial blood vessels, the eyes and 
kidneys. Prolonged hypertension can also lead to enlargement of the heart and may 
cause heart failure. This disease is usually asymptomatic until the damaging effects of 
hypertension are observed. Therefore, hypertension is known as the "silent killer."
Several survey studies for assessing the burden of hypertension in different societies 
revealed that many subjects with hypertension were unaware of their disease, many of 
the aware subjects were not on treatment, and many of the treated patients were not 
controlled properly, particularly in developing countries. Hypertension afflicts more 
than one billion population worldwide and is a leading cause of morbidity and 
mortality. It has been predicted that in year 2025 it will increase by 24% in developed 
countries and 80% in developing countries. However, the expected increase may be 
much higher than these projections.
This book is another contribution to the application of new knowledge in the area of 
hypertension. Authors of this book are from different parts of the world sharing their 
new knowledge and experience in the direction of deep understanding and more 
clarification of the disease. They look from different angles to hypertension, providing 
an invaluable resource not only for clinicians, but also for all medical sciences students 
and health providers. I hope this book will provide new insight into hypertension 
disease and greater visibility and access to detection and treatment of vulnerable 

Prof. Hossein Babaei

Drug Applied Research Center,
School of Pharmacy,
Tabriz University of Medical Sciences,


Chapter 1 New Therapeutics in Hypertension 1
Jorge Luis León Alvarez

Chapter 2 Dual L/N-Type Ca2+ Channel Blocker: Cilnidipine as a New Type of Antihypertensive Drug 29
Akira Takahara

Chapter 3 Hypertension and Chronic Kidney Disease: Cause and Consequence – Therapeutic Considerations 45
Elsa Morgado and Pedro Leão Neves

Chapter 4 Potassium-Sparing Diuretics in Hypertension 67
Cristiana Catena, GianLuca Colussi and Leonardo A. Sechi

Chapter 5 Hypertension and Renin-Angiotensin System 85
Roberto de Barros Silva

Chapter 6 Pharmacokinetic Interactions of Antihypertensive Drugs with Citrus Juices 95
Yoshihiro Uesawa

Chapter 7 Drug Interaction Exposures in an Intensive Care Unit: Population Under Antihypertensive Use 121
Érica Freire de Vasconcelos-Pereira, Mônica Cristina Toffoli-Kadri, Leandro dos Santos Maciel Cardinal and Vanessa Terezinha Gubert de Matos

Chapter 8 The Use of Antihypertensive Medicines in Primary Health Care Settings 131
Marc Twagirumukiza, Jan De Maeseneer, Thierry Christiaens, Robert Vander Stichele and Luc Van Bortel

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Published by: Unknown - Monday, January 21, 2013


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