Open Access Medical Books


Edited by John S. D. Chan .

The idea for publishing a book on diabetic nephropathy has been developed during 
the last several years as my interest in studying diabetic complications has 
increased. The need for a book that described the various novel and old molecules 
involved in the development of diabetic nephropathy and the trend of future 
research became apparent. The book describes the important role of intrarenal reninangiotensin- 
aldosterone system and immune system in the development of diabetic 
nephropathy as well as provided data on the biochemical and pathological changes 
in diabetic nephropathy. Relevant information on the treatments of diabetic 
nephropathy is also provided.
The authors are internationally known for their work in diabetic nephropathy. Each 
chapter has been peer-reviewed and edited and provide up-to-date information on 
the topic.
I hope that the book will be useful for researchers working in the field of diabetic 

John S. D. Chan
Professor of Medicine at the Université de Montréal,
Chief of the Laboratory of Molecular Nephrology and Endocrinology,
Research Centre - Centre hospitalier de l’Université de Montréal (CRCHUM)


Section 1 Systemic and Local Intrarenal Renin-Angiotensin-Aldosterone System in the Development of Diabetic Nephropathy .

Chapter 1 Up-Regulation of Renin-Angiotensin System in Diabetes and Hypertension: Implications on the Development of Diabetic Nephropathy 3
Dulce Elena Casarini, Danielle Yuri Arita, Tatiana Sousa Cunha, Fernanda Aparecida Ronchi, Danielle Sanches Aragão, Rodolfo Mattar Rosa, Nadia Sousa Cunha Bertoncello and Fernanda Klein Marcondes

Chapter 2 Renal Angiotensinogen Gene Expression and Tubular Atrophy in Diabetic Nephropathy 
Brice E. T. Nouthe, Maya Saleh, Shao-Ling Zhang and John S. D. Chan

Chapter 3 Diabetic Nephropathy: Role of Aldosterone and Benefits of Therapy with Aldosterone Receptor Blocker 41
Jayson Yap and Mohammad G. Saklayen

Chapter 4 Drug and Diabetic Nephropathy 57
Rozina Rani

Section 2 Novel Therapeutic Molecules in Diabetic Nephropathy .

Chapter 5 Kidney ADP-Ribosyl Cyclase Inhibitors as a Therapeutic Tool for Diabetic Nephropathy 85
Uh-Hyun Kim

Chapter 6 Significance of Advanced Glycation End-Products (AGE) and the Receptor for AGE (RAGE) in Diabetic Nephropathy 97
Tarek Kamal, Yasuhiko Yamamoto and Hiroshi Yamamoto

Chapter 7 The Contribution of Fibronectin ED-A Expression to Myofibroblast Transdifferentiation in Diabetic Renal Fibrosis 109
Keisuke Ina, Hirokazu Kitamura, Shuji Tatsukawa and Yoshihisa Fujikura

Chapter 8 Immunoinflammation in Diabetic Nephropathy: Molecular Mechanisms and Therapeutic Options 127
Virginia Lopez-Parra, Beñat Mallavia, Jesus Egido and Carmen Gomez-Guerrero

Chapter 9 Study of Diabetic Hypertensive Nephropathy in the Local Population of Pakistan 147
Samreen Riaz and Saadia Shahzad Alam .

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Published by: Unknown - Wednesday, January 23, 2013


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