Open Access Medical Books

INFLAMMATORY DISEASES – A MODERN PERSPECTIVE

INFLAMMATORY DISEASES
Edited by Amit Nagal .

thoroughly revised collection of papers on inflammation. This book explores a wide 
range of topics relevant to inflammation and inflammatory diseases while its main 
objective is to help in understanding the molecular mechanism and a concrete review 
of inflammation. One of the interesting things about this book is its diversity in topics 
which include pharmacology, medicine, rational drug design, microbiology and 
biochemistry. Each topic focuses on inflammation and its related disease thus giving a 
unique platform which integrates all the useful information regarding inflammation. 
About the Contents : 
Chapter 1 contains an introduction to Urinary trypsin inhibitor (UTI), a serine protease 
inhibitor which is found to be a good therapeutic option for endotoxin-related 
inflammatory disorders such as DIC, acute lung injury in targeted mice model. 
Chapter 2 concerns structure based molecule design approaches and comparative 
docking studies of various hnps-PLA2 indole inhibitor derivatives. In this study they 
proved that molecule 13h could be a novel anti-inflammatory drug. 
Chapter 3 formally supports a model wherein Th1 and IL-17+ T cells mechanistically 
interact and collaboratively contribute to BD skin pathogenesis. This is found to be a 
beneficial for further study in Behcet’s disease skin lesions .
Chapter 4 contains a review of the most Activate Protein C role in inflammatory 
disease .
Chapter 5 is devoted to the formal theory of role and expression TrkA receptor in the 
pulmonary hypertension. This chapter well explains the importance of TrkA receptor.
Chapter 6 concerns review of cytokines, their major role in chronic inflammatory 
diseases and cancers and it also elucidates challenge and significance of the 
cytokinome profile.
Chapter 7 examines Periodontal Inflammation as Risk Factor for Pancreatic Diseases. It 
also explores and investigates pancreatic tissue for the potential presence of 
periodontopathogenic microorganisms.
Chapter 8 is entirely devoted to Polyunsaturated fatty acids. It well explains that they 
play critical roles in physiologic and pathophysiologic processes involving the immune 
system and have the ability to alter cellular responses as free fatty acids, most interest is 
on the properties of the array of metabolic products which they generate. These form a 
regulatory network which either down or up-regulates the inflammatory reaction.
Chapter 9 concerns the importance of asthma especially scientific knowledge which 
can help to address how and why this condition occurs and may contribute to a better 
understanding of the classification of each asthma patient.
Chapter 10 is discussion of the functional and structural characterization of AC0T7 in 
macrophages and their role in inflammation.
Chapter 11 contains interesting observations of dietary n-3 PUFA and n-3 PUFA-rich
food such as salmon which plays crucial role to reduce inflammatory bowel disease.

Amit Nagal, PhD
Bioinformatics Analyst Ocimum Biosolution, Hyderabad,
India.



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