Open Access Medical Books

MEDICINAL CHEMISTRY AND DRUG DESIGN

MEDICINAL CHEMISTRY
Edited by Deniz Ekinci ;
418 pages .

Medicinal chemistry is a discipline at the intersection of chemistry, especially synthetic 
organic chemistry, and pharmacology and various other biological specialties, where 
they are involved with design, chemical synthesis and development for market of 
pharmaceutical agents (drugs). Compounds used in medical applications are most 
often organic compounds, which are often divided into the broad classes of small 
organic molecules and biologics, the latter of which are most often medicinal 
preparations of proteins. Inorganic and organometallic compounds are also useful as 
drugs. In the recent years discovery of specific enzyme inhibitors has received great 
attention due to their potential to be used in pharmacological applications.
Drug design is the inventive process of finding new medications based on the 
knowledge of a biological target. A drug is most commonly an organic small molecule 
that activates or inhibits the function of a biomolecule such as a protein, which in turn 
results in a therapeutic benefit to the organism. In the most basic sense, drug design 
involves the design of small molecules that are complementary in shape and charge to 
the biomolecular target with which they interact and therefore will bind to it. 
Although extensive research has been performed on medicinal chemistry or drug 
design for many years, there is still deep need of understanding the interactions of
drug candidates with biomolecules.
This book titled “Medicinal Chemistry and Drug Design” contains a selection of chapters 
focused on the research area of enzyme inhibitors, molecular aspects of drug 
metabolism, organic synthesis, prodrug synthesis, in silico studies and chemical 
compounds used in relevant approaches. The book provides an overview on basic 
issues and some of the recent developments in medicinal science and technology.
Particular emphasis is devoted to both theoretical and experimental aspect of modern 
drug design. The primary target audience for the book includes students, researchers, 
biologists, chemists, chemical engineers and professionals who are interested in 
associated areas.
The textbook is written by international scientists with expertise in chemistry, protein 
biochemistry, enzymology, molecular biology and genetics many of which are active 
in biochemical and biomedical research. I would like to acknowledge the authors for 
their contribution to the book. We hope that the textbook will enhance the knowledge 
of scientists in the complexities of some medicinal approaches; it will stimulate both 
professionals and students to dedicate part of their future research in understanding 
relevant mechanisms and applications.

Dr. Deniz Ekinci
Associate Professor of Biochemistry
Ondokuz Mayıs University
Turkey

CONTENTS : 

Chapter 1 Kojic Acid Derivatives 1Mutlu D. Aytemir and G. Karakaya

Chapter 2 Analysis of Protein Interaction Networks to Prioritize 
Drug Targets of Neglected-Diseases Pathogens 27
Aldo Segura-Cabrera, Carlos A. García-Pérez, Mario A. Rodríguez-Pérez, Xianwu Guo,
Gildardo Rivera and Virgilio Bocanegra-García

Chapter 3 Recent Applications of Quantitative 
Structure-Activity Relationships in Drug Design 55
Omar Deeb

Chapter 4 Atherosclerosis and Antihyperlipidemic Agents 83
Laila Mahmoud Mohamed Gad

Chapter 5 Inhibitors of Serine Proteinase – Application in Agriculture and Medicine 103
Rinat Islamov, Tatyana Kustova and Alexander Ilin

Chapter 6 Pyrrolobenzodiazepines as Sequence Selective DNA Binding Agents 119
Ahmed Kamal, M. Kashi Reddy, Ajay Kumar Srivastava and Y. V. V. Srikanth

Chapter 7 Regulation of EC-SOD in Hypoxic Adipocytes 143
Tetsuro Kamiya, Hirokazu Hara, Naoki Inagaki and Tetsuo Adachi

Chapter 8 Development of an Ultrasensitive CRP Latex 
Agglutination Reagent by Using Amino Acid Spacers 159
Tomoe Komoriya, Kazuaki Yoshimune, Masahiro Ogawa, Mitsuhiko Moriyama and Hideki Kohno

Chapter 9 Pattern Recognition Receptors Based Immune Adjuvants: 
Their Role and Importance in Vaccine Design 177
Halmuthur M. Sampath Kumar, Irfan Hyder and Parvinder Pal Singh

Chapter 10 Microarray Analysis in Drug Discovery 
and Biomarker Identification 203
Yushi Liu and Joseph S. Verducci

Chapter 11 Supraventricular Tachycardia Due to Dopamine Infused Through Epidural Catheter Accidentally (A Case Report and Review) 227
Demet Coskun and Ahmet Mahli

Chapter 12 Effective Kinetic Methods and Tools in Investigating 
the Mechanism of Action of Specific Hydrolases 235
Emmanuel M. Papamichael, Panagiota-Yiolanda Stergiou, Athanasios Foukis, Marina Kokkinou and Leonidas G. Theodorou

Chapter 13 Aluminium – Non-Essential Activator of Pepsin: Kinetics and Thermodynamics 275
Vesna Pavelkic, Tanja Brdaric and Kristina Gopcevic

Chapter 14 Peptides and Peptidomimetics in Medicinal Chemistry 297
Paolo Ruzza

Chapter 15 Carbonic Anhydrase Inhibitors and Activators: Small Organic Molecules as Drugs and Prodrugs 315
Murat Şentürk, Hüseyin Çavdar, Oktay Talaz and Claudiu T. Supuran

Chapter 16 Stochastic Simulation for Biochemical Reaction Networks in Infectious Disease 329
Shailza Singh and Sonali Shinde

Chapter 17 Alternative Perspectives of Enzyme Kinetic Modeling 357
Ryan Walsh

Chapter 18 Molecular Modeling and Simulation 
of Membrane Transport Proteins 373
Andreas Jurik, Freya Klepsch and Barbara Zdrazil .


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