Open Access Medical Books


Edited by Bernhard Schaller .

Molecular Imaging represents a unique project that was only possible by the exceptional 
InTech support. The authors of the book give therefore an overview of the relatively 
new topic of molecular imaging, with broad background to basic but also clinical 
sciences. The present book is best suited not only for the beginners in the area to gain 
some overview of the feature, but also for professionals to see trends of other groups 
from all over the world.
Molecular imaging has rapidly gained influence in medicine, not only for different 
research projects, but also in the view of personalized medicine. The door for 
personalized medicine is now widely open. Also in this direction, the present book 
gives more than only a little food for thought.
Even if Molecular Imaging covers a broad part of the whole topic, it was and it is not 
our goal to be comprehensive. Such a project can never be complete, and different 
authors from all over the world can only give some insights of their daily work. Ideas 
how molecular imaging will develop in the near future present a special delicacy. 
We hope that readers will enjoy this book. I would like to thank all those who made 
the project possible, especially Ms Pantar and Mrs Durovic from InTech. They both 
were angels for the authors.

Prof. Bernhard Schaller, MD, PhD, DSC
Department of Neurosurgery,
University of Paris 7, Paris,


Part 1 Background, Theories and Methods of Molecular Imaging .

Chapter 1 Modern Quantitative Techniques for PET/CT/MR Hybrid Imaging 3
Babak Saboury, Mateen Moghbel, Sandip Basu and Abass Alavi

Chapter 2 Radiolabeled Nanoparticles for Molecular Imaging 15
Enrique Morales-Avila, Guillermina Ferro-Flores, Blanca E. Ocampo-García and Flor de María Ramírez

Chapter 3 Fluorescent X-Ray Computed Tomography Using Synchrotron Radiation Towards Molecular Imaging 39
Tetsuya Yuasa and Tohoru Takeda

Chapter 4 Investigating the Conformation of HER Membrane Proteins in Cells via Single Molecule and FLIM Microscopy 71
Marisa L. Martin-Fernandez, David T. Clarke, Michael Hirsch, Sarah R. Needham, Selene K. Roberts, Daniel J. Rolfe, Chris J. Tynan, Stephen E.D. Webb, Martyn Winn, and Laura Zanetti Domingues

Chapter 5 Nucleic Acid Aptamers for In Vivo Molecular Imaging 95
Vittorio de Franciscis, Anna Rienzo and Laura Cerchia

Chapter 6 3D Optical Imaging of Fluorescent Agents in Biological Tissues 117
Manuel Freiberger and Hermann Scharfetter

Chapter 7 Focal Modulation Microscopy: Principle and Techniques 145
Nanguang Chen, Guangjun Gao and Shau Poh Chong

Chapter 8 Automated Segmentation and Morphometry of Cell and Tissue Structures. Selected Algorithms in ImageJ 183
Dimiter Prodanov and Kris Verstreken

Part 2 Specific Applications with Clinical Examples .

Chapter 9 Molecular Imaging of Stem Cells: A New Area for Neuroscience 211
Nora Sandu, Fatemeh Momen-Heravi, Pooyan Sadr-Eshkevari, Ali Arvantaj and Bernhard Schaller

Chapter 10 Molecular MRI of Atherosclerosis 221
B.C. Te Boekhorst and K. Nicolay

Chapter 11 Molecular Imaging of Atherosclerotic Coronary Plaques by Fluorescent Angioscopy 
Yasumi Uchida and Yuko Maezawa

Chapter 12 Molecular Imaging of Tumor Angiogenesis 269
Shaunagh McDermott and Alexander Guimaraes

Chapter 13 PET and SPECT Imaging of Tumor Angiogenesis 303
Marcian E. Van Dort, Pedram Navid-Azarbaijani, Rajesh Ranga, Alnawaz Rehemtulla, Brian D Ross, Allan E David and Mahaveer S Bhojani

Chapter 14 Molecular Imaging Studies on CD133+ Hematopoietic Stem Cells From Human Umbilical Cord Blood 317
L.F. Pavon, L.C. Marti, T.T. Sibov, M.I. Camargo-Mathias, Jr.E. Amaro and L.F. Gamarra

Chapter 15 Diagnostic and Treatment Response Imaging in Lymphomas 331
Xingchen Wu and Pirkko-Liisa Kellokumpu-Lehtinen 

Chapter 16 Targeting EGFR and HER2 for Molecular Imaging of Cancer 351
Haibiao Gong, Lakshmi Sampath, Joy L. Kovar and D. Mike Olive

Part 3 Recent Developments and Trends .

Chapter 17 Recent Development and Trends in Molecular Imaging Probes for Prostate Cancer 
Wenbin Zeng, Zhiguo Liu and Wei Wang .

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