Open Access Medical Books

PSORIASIS – A SYSTEMIC DISEASE

PSORIASIS – A SYSTEMIC DISEASE

Edited by Jose O'Daly .

Open Access .
216 pages .
ISBN 978-953-51-0281-6 .


The purpose of this book is to present a comprehensive analysis of Psoriasis, a disease  that affects approximately 2-3% of humanity in all countries. Psoriasis existence is  surveyed since the clay tablets of Assyrians and Babylonians 3.000-5.000 years ago,  thru the middle ages, the renaissance, XIX and XX centuries. In the first and second  part of the XX century clinical forms were described, as well as the role of  keratinocytes, multifactorial genes, T lymphocytes, mast cells, natural killer cells,  nerve growth factor, psychosomatics, neuropeptides and environmental factors  triggering the disease. Treatment of psoriasis is detailed thru history from old  ointments in the XVIII and XIX centuries, up to UVA irradiation, new  immunosuppressive and immunomodulatory drugs as parasite vaccines in the XX and  XXI centuries. Epidemiology of psoriasis, a disease that affects around 125 million  people (mainly Caucasians ), is described. Psoriasis is less common in Chinese,  Eskimos, West Africans and African-Americans. The course and evolution of psoriasis  is very hard to predict. A description of the wide clinical spectra is presented,  considering psoriasis as a systemic disease a better concept to explain its pathogenesis,  with manifestations in skin, nails, tendons, ligaments, spinal cord, joints and  ophthalmic complications easily missed. The balance between angiogenic and  antiangiogenic factors are proposed to explain the pathogenesis in psoriatic skin.
Psoriasis and atherosclerosis are interrelated; pathogenic mechanisms are shared  between the two diseases inducing inflammation.
Histological characteristics are discussed in depth in plaque psoriasis describing cells  and cytokines involved in the process as well as the genes responsible for  inflammation. Assessment of psoriasis severity is explained in an easy way useful for  the clinician and researcher working in psoriasis. The role of streptococcal infections  and fungal infections as well as Malassezia species and lipophilic yeast are presented  as well as antifungal treatments for control of psoriasis.
Synovitis, acne, pustulosis hyperostosis, and osteitis (SAPHO syndrome) are discussed  in its relation with psoriasis with many features in common with ankylosing  spondilytis and psoriatic arthritis. Peptidylarginine deiminases are discussed  concerning their expression in keratinocytes, their association with skin diseases and  as therapeutics and prophylactic targets in severe psoriasis.
We would like to acknowledge to the contributors to the several chapters as follows: 


Ines Brajac and Franjo Gruber
Department of Dermatovenerology, University Hospital Centre Rijeka Croatia

Susana Coimbra1,2, Hugo Oliveira3, Américo Figueiredo3,
Petronila Rocha-Pereira1,4 and Alice Santos-Silva1,5
1Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal
2Centro de Investigação das Tecnologias da Saúde (CITS) – Instituto Politécnico da Saúde 
Norte, CESPU, Gandra-Paredes, Portugal 
3Serviço de Dermatologia, Hospitais da Universidade de Coimbra, Coimbra, Portugal 
4Centro de Investigação em Ciências da Saúde (CICS), Universidade da Beira Interior, Covilhã, 
Portugal 
5Departamento de Ciências Biológicas, Laboratório de Bioquímica, Faculdade de Farmácia,
Universidade do Porto, Porto, Portugal

Asja Prohić
Department of Dermatovenerology, University Clinical Center of Sarajevo
Bosnia and Herzegovina

Gunter Assmann
University Medical School of Saarland, Germany

Shibo Ying1, Michel Simon2, Guy Serre3 and Hidenari Takahara1
1Ibaraki University, Japan
2CNRS-University of Toulouse III, France

Jose O'Daly
Astralis Ltd, Irvington, NJ
USA
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CONTENTS OF THE TEXTBOOK :



 1 Psoriasis, a Systemic Disease Beyond the Skin, as Evidenced by Psoriatic Arthritis and Many Comorbities – Clinical Remission with a Leishmania Amastigotes Vaccine, a Serendipity Finding 1 J.A. O’Daly

 2 History of Psoriasis 57 Ines Brajac and Franjo Gruber

 3 Psoriasis: Epidemiology, Clinical and Histological Features, Triggering Factors, Assessment of Severity and Psychosocial Aspects 69 Susana Coimbra, Hugo Oliveira, Américo Figueiredo, Petronila Rocha-Pereira and Alice Santos-Silva

 4 Psoriasis and Malassezia Yeasts 89 Asja Prohić

 5 SAPHO Syndrome 103 Gunter Assmann

 6 Peptidylarginine Deiminases and Protein Deimination in Skin Physiopathology 117 Shibo Ying, Michel Simon, Guy Serre and Hidenari Takahara

 7 Insights into the Pathogenesis and Treatment of Psoriasis 133 Robyn S. Fallen, Aupam Mitra and Hermenio C. Lima

 8 Psoriasis 159 Adolfo Fernandez-Obregon .




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