Open Access Medical Books

RNA PROCESSING

RNA PROCESSING
Edited by Paula Grabowski .
258 pages .

RNA functions broadly as informational molecule, genome, enzyme and machinery 
for RNA processing. While these functions reflect ancient activities, they also remain 
vital components of contemporary biochemical pathways. In eukaryotic cells RNA 
processing impacts the biogenesis of RNA molecules of essentially every shape and 
function from cleavage at the 5 ́ and 3 ́ ends to the removal of intronic sequences by 
splicing. The processing and modification of ribosomal RNAs are essential for the 
assembly of the protein synthesis machinery.
RNA processing is an integral part of the life cycle that gives rise to infectious HIV-1 
particles. The processing of informational mRNAs is integrated into the flow of gene 
expression during co-transcriptional splicing, 3 ́-end formation and transport.
Alternative splicing and 3 ́ end formation diversifies protein functions, and varies with 
the developmental stage and cell type. RNA processing allows for the coordination of 
mRNA production and quality control enforcement through micro RNAs regulatory 
contributions fine-tuning gene expression' throughout the genome.
The collection of chapters in this volume describes the current state of understanding 
of the broad array of RNA processing events in animal and plant cells, key 
unanswered questions, and cutting edge approaches available to address these 
questions. Some questions discussed in this volume include, how viruses subvert the 
RNA processing machinery of the host cell, how the coordination of co-transcriptional 
RNA processing is regulated at the level of chromatin, the status of RNA processing in 
plant organelles, and how micro RNA machinery is biosynthesized and regulated.

Paula Grabowski
Dept of Biological Sciences
University of Pittsburgh
USA

CONTENTS :

Part 1 RNA Processing and Chromatin 1

Chapter 1 Chromatin Remodelling and RNA Processing 3
Stefanie Böhm and Ann-Kristin Östlund Farrants

Chapter 2 Hide and Go Seek: Activation 
of the Secretory-Specific Poly (A) Site of Igh by Transcription Elongation Factors 27
Christine Milcarek

Chapter 3 The Worlds of Splicing and Chromatin Collide 61
J. Adam Hall and Philippe T. Georgel

Part 2 RNA Processing and Viral Systems 77


Chapter 4 The Regulation of HIV-1 mRNA Biogenesis 79
Massimo Caputi

Chapter 5 Subversion of RNA Processing Pathways 
by the Hepatitis delta Virus 101
Yasnee Beeharry and Martin Pelchat

Part 3 RNA Processing in Diverse Model Systems 117


Chapter 6 Alternative Polyadenylation in Yeast: 3´-UTR 
Elements and Processing Factors Acting at a Distance 119
Mónica Lamas-Maceiras, Silvia Seoane and María A. Freire-Picos

Chapter 7 RNA Processing Activities 
of the Arabidopsis Argonaute Protein Family 137
Ki Wook Kim, Andrew L Eamens and Peter M Waterhouse

Chapter 8 RNAi in Agriculturally-Important Arthropods 157
Katherine Aronstein, Brenda Oppert and Marcé D. Lorenzen
Chapter 9 RNA Processing During Early Embryogenesis: Managing Storage, Utilisation and Destruction 181Angus Macaulay, Sara Scantland and Claude Robert

Part 4 RNA Processing Factors 205


Chapter 10 Recent Advances in Understanding 
of Alternative Splicing in Neuronal Pathogenesis 207
Hung-Hsi Chen, Jung-Chun Lin and Woan-Yuh Tarn

Chapter 11 The Lsm Proteins: 
Ring Architectures for RNA Capture 229
Jens M. Moll, Meghna Sobti and Bridget C. Mabbutt .


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