Open Access Medical Books

SKIN BIOPSY – PERSPECTIVES

SKIN BIOPSY
Edited by Uday Khopkar .
348 pages .

I am pleased to present this book on the techniques and applications of skin biopsy.
The book is organized into four sections as per the applicability of the techniques 
described in each of the chapters.
Skin biopsy is the most frequent diagnostic investigation undertaken by a 
dermatologist. Large amount of information is available upon interpretation of skin 
biopsies. However, in clinical practice, difficulties in interpretation of skin biopsies are 
not uncommon. Many of these difficulties arise from variations in technique of 
performing or processing a skin biopsy. It is with this intent that we decided to focus 
on the methodology of performing skin biopsies in different clinical scenarios.
The first section of the book deals with common clinical applications of skin biopsy in 
humans. While it is focused largely on the nuances and pitfalls in technique of 
performing a skin biopsy, the second section is dedicated to specialized applications of 
skin biopsy in the diagnosis of uncommon diseases. These clinical situations, being 
uncommon, demand special attention to appropriate technique while taking the 
biopsy in the clinic as well as processing it in the laboratory. Some of these conditions 
are systemic diseases establishing diagnosis for which is dependent on the correct
sampling and processing of skin biopsy.
Technology is moving at a rapid pace and finds applications in every field. Skin as a 
tissue is being increasingly used in research laboratories around the world. Many 
research methods have been developed based on skin tissue culture and these have 
been dealt with in some detail in the third section of this book.
Finally, the last section deals with the use of skin biopsy to monitor impact of 
environmental changes on animals, more specifically - marine life. This brings into 
focus the wider applications of skin biopsy in environmental sciences and biology in 
general.
I am thankful to the authors for contributing their excellent scientific material to this 
book, in spite of their busy schedules, which requires special appreciation. I am also 
indebted to the InTech team for coordinating all the correspondence and looking after 
the technical matters and following a strict publication protocol. Special thanks are 
due to Dragana Manestar of InTech for her patience and perseverance in 
correspondence that has led to this successful conclusion.
This book is basically aimed at improving outcomes of skin biopsies aimed at 
diagnosing skin diseases. I hope that this drop in the ocean of information around us 
improves this outcome for the final beneficiary of all medical literature - the patient.

Uday Khopkar
GS Medical College and KEM Hospital
Mumbai, India

CONTENTS :

Part 1 Skin Biopsy Procedure – Do’s and Don’ts 1


Chapter 1 Skin Biopsy Procedures: 
How and Where to Perform a Proper Biopsy 3
Z. Seia, L. Musso, Stefania Palazzini and M. Bertero

Chapter 2 General Methods in Preparation of Skin Biopsies for 
Haematoxylin & Eosin Stain and Immunohistochemistry 19
Khitam Al-Refu

Chapter 3 Types and Selection Criteria 
for Various Skin Biopsy Procedures 31
Divey Manocha, Nidhi Bansal and Ramsay S. Farah

Part 2 Skin Biopsy Applications in Skin Diseases 51


Chapter 4 New Diagnostic Applications in Sporotrichosis 53
Rosely Maria Zancope-Oliveira, Rodrigo de Almeida-Paes, Manoel Marques Evangelista de Oliveira, Dayvison Francis Saraiva Freitas and Maria Clara Gutierrez Galhardo

Chapter 5 Skin Biopsy in Leprosy 73
Avninder Singh, Xiaoman Weng and Indira Nath

Chapter 6 Severe Drug-Induced Skin Reactions: 
Clinical Pattern, Diagnostics and Therapy 87
Mirjana Ziemer and Maja Mockenhaupt

Chapter 7 Severe Cutaneous Adverse Reactions 117
Suran Fernando

Chapter 8 Mechanisms Regulating Epidermal 
Innervation in Pruritus of Atopic Dermatitis 157
Mitsutoshi Tominaga and Kenji Takamori

Chapter 9 Diagnosing Vascular Dementia by 
Skin Biopsy - Uniqueness of CADASIL 183
Saara Tikka, Kati Mykkänen, Maija Junna, Robert Bergholm,Minna Pöyhönen,
Marc Baumann, Matti Viitanen and Hannu Kalimo

Part 3 Research Applications of Human Skin Biopsy 195


Chapter 10 The Clinicopathologic and Molecular 
Aspects of Non-Melanoma Skin Cancer 197
Anthony P. Tufaro, Nijaguna B. Prasad, Anne C. Fischer and Allan D. Hess

Chapter 11 Stress Hormone and Skin Disease 209
Jung Eun Kim and Hyun Jeong Park

Chapter 12 Use of Reconstructed Skin 
Specimens to Analyze Stratum corneum Remodeling and Epidermal Modifications 225
Paolo U. Giacomoni, Kelly Dong, Donald Collins, Nadine Pernodet and Daniel Yarosh

Chapter 13 Keratinocyte Culture Techniques 
in Medical and Scientific Applications 241
Stefanie Kuhn, Christine Radtke, Christina Allmeling, Peter M. Vogt and Kerstin Reimers

Chapter 14 Bioengineered Skin 261
María José Escámez, Lucía Martínez-Santamaría, Marta García, Sara Guerrero-Aspizua, Marta Carretero, Fernando Larcher, Álvaro Meana and Marcela Del Río

Part 4 Skin Biopsy as a Tool to Environmental Research 297


Chapter 15 Skin Biopsies as Tools to 
Measure Fish Coloration and Colour Change 299
P. Andreas Svensson and Helen Nilsson Sköld

Chapter 16 Multi-Trial Ecotoxicological 
Diagnostic Tool in Cetacean Skin Biopsies 317
Maria Cristina Fossi and Letizia Marsili .


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