Open Access Medical Books



Edited by David C. Gaze .

Open Access .
491 pages .

The cardiovascular system includes the heart located centrally in the thorax and the vessels of the body which carry blood. The cardiovascular (or circulatory) system supplies oxygen from inspired air, via the lungs to the tissues around the body. It is also responsible for the removal of the waste product, carbon dioxide via air expired from the lungs. The cardiovascular system also transports nutrients such as electrolytes, amino acids, enzymes, hormones which are integral to cellular respiration, metabolism and immunity.
This book is not meant to be an all encompassing text on cardiovascular physiology and pathology rather a selection of chapters from experts in the field who describe recent advances in basic and clinical sciences. As such, the text is divided into three main sections:

  • Cardiovascular Physiology

In this section, the control of the cardiovascular system is discussed in particular the heaemodynamic mechanisms controlling blood volume, flow and the regulation of systolic blood pressure. The next chapter investigates the molecular control of smooth muscle cell (SMC) differentiation marker genes by serum response factor (SRF) including the interaction of myocardin as a potent cofactor of SRF in SMC differentiation. The chapter also details the interaction of GATA-6, Klf4, LIM-only proteins CRP1 and 2 and PIAS-1 with SRF. The following chapter reports on trans fatty acids (TFA) and human health, detailing the biochemistry of trans fats as well as recommended daily intake. The chapter describes both animal and human studies of TFA. There are details on the analytical determination of TFA as well as their potential antioxidants. There is also a comprehensive overview of TFA and legislative control in food production and consumption. This is followed by a chapter on the control and coordination of vasomotor tone in the microcirculation; concentrating on the cellular membrane potential and potassium channels, the role of prostaglandins, nitric oxide and endothelium-derived hyperpolarizing factor as paracrine signalling in the wall of the vessel. There is also detail of the role of gap junctions in vascular smooth muscle and endothelium communication processes. The following chapter discusses the concept of hemodynamics, detailing the relationship between physical factors and the effect on blood flow through the vessel in laminar or turbulent flow patterns....

David C. Gaze
Dept of Chemical Pathology Clinical Blood Sciences,
St George’s Healthcare NHS Trust, London
United Kingdom



Section 1 Cardiovascular Physiology .

 1 Control of Cardiovascular System 3 Mikhail Rudenko, Olga Voronova, Vladimir Zernov, Konstantin Mamberger, Dmitry Makedonsky, Sergey Rudenko and Sergey Kolmakov

 2 Molecular Control of Smooth Muscle Cell Differentiation Marker Genes by Serum Response Factor and Its Interacting Proteins 23 Tadashi Yoshida

 3 Trans Fatty Acids and Human Health 43 Sebastjan Filip and Rajko Vidrih

 4 Control and Coordination of Vasomotor Tone in the Microcirculation 65 Mauricio A. Lillo, Francisco R. Pérez, Mariela Puebla, Pablo S. Gaete and Xavier F. Figueroa

 5 Hemodynamics 95 Ali Nasimi

 6 Adenosinergic System in the Mesenteric Vessels 111 Ana Leitão-Rocha, Joana Beatriz Sousa and Carmen Diniz

 7 Endothelial Nitric Oxide Synthase, Nitric Oxide and Metabolic Disturbances in the Vascular System 135 Grażyna Lutosławska

Section 2 Cardiovascular Diagnostics .

 8 The Diagnostic Performance of Cardiovascular System and Evaluation of Hemodynamic Parameters Based on Heart Cycle Phase Analysis 157 Mikhail Rudenko, Olga Voronova, Vladimir Zernov, Konstantin Mamberger, Dmitry Makedonsky, Sergey Rudenko, Yuri Fedossov, Alexander Duyzhikov, Anatoly Orlov and Sergey Sobin

 9 Biophysical Phenomena in Blood Flow System in the Process of Indirect Arterial Pressure Measurement 179 Mikhail Rudenko, Olga Voronova and Vladimir Zernov

 10 Interrelation Between the Changes of Phase Functions of Cardiac Muscle Contraction and Biochemical Processes as an Algorithm for Identifying Local Pathologies in Cardiovascular System 195 Yury Fedosov, Stanislav Zhigalov, Mikhail Rudenko, Vladimir Zernov and Olga Voronova

 11 Application of Computational Intelligence Techniques for Cardiovascular Diagnostics 211
C. Nataraj, A. Jalali and P. Ghorbanian

 12 Analysis of Time Course Changes in the Cardiovascular Response to Head-Up Tilt in Fighter Pilots 241 David G. Newman and Robin Callister

Section 3 Clinical Impact of Cardiovascular Physiology and Pathophysiology .

 13 Physical Activity and Cardiovascular Health 257 Raul A. Martins

 14 Cardiovascular Disease Risk Factors 279 Reza Amani and Nasrin Sharifi

 15 Cardiovascular and Cerebrovascular Problems in the Development of Cognitive Impairment: For Medical Professionals Involved in the Treatment of Atherosclerosis 311 Michihiro Suwa

 16 French Paradox, Polyphenols and Cardiovascular Protection: The Oestrogenic Receptor-α Implication 319 Tassadit Benaissa, Thierry Ragot and Angela Tesse

 17 Importance of Dermatology in Infective Endocarditis 345 Servy Amandine, Jones Meriem and Valeyrie-Allanore Laurence

 18 Cardiovascular Risk Factors: Implications in Diabetes, Other Disease States and Herbal Drugs 365 Steve Ogbonnia

 19 Morphology and Functional Changes of Intestine, Trophology Status and Systemic Inflammation in Patients with Chronic Heart Failure 383 G.P. Arutyunov and N.A. Bylova

 20 Evaluation and Treatment of Hypotension in Premature Infants 419 Shoichi Ezaki and Masanori Tamura

 21 Role of Echocardiography in Research into Neglected Cardiovascular Diseases in Sub-Saharan Africa 445 Ana Olga Mocumbi

 22 Psychophysiological Cardiovascular Functioning in Hostile Defensive Women 465 Francisco Palmero and Cristina Guerrero

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Published by: younes younes - Monday, January 21, 2013


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