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Tumours of the Pleura

Tumours of the Pleura
Mesothelioma is the most frequent neoplasm affecting the pleura
and remains a major health threat for many years to come.
Although the causation by asbestos is firmly established since 
more than 50 years, in many world regions, the use of this dangerous 
carcinogen peaked between 1970 and 1990. Although 
now banned in the USA and most European countries, incidence 
and mortality rates are still climbing. In Western Europe 
alone, more than 200 000 mesothelioma deaths have been predicted 
to occur during the next 25 years. Despite this grim outlook, 
the worldwide production of asbestos has not declined 
Less is known about the cellular and molecular mechanisms 
operative in the evolution of asbestos-induced mesothelioma.
Clastogenic effects are well documented, but the sequential 
acquisition of genetic alterations which typically form the basis 
of tumour development, are still poorly understood. During the 
past decade, several studies have identified sequences of the 
oncogenic SV40 virus in human mesotheliomas, but it remains 
to be shown whether or not SV40 is causally involved in their 



  1. Definition
  2. ICD-O Codes
  3. Synonyms
  4. Epidemiology
  5. Etiology
  6. Pathogenesis
  7. Clinical features
  8. Macroscopy and localization
  9. Tumour spread and staging
  10. Histopathology
  11. Epithelioid mesothelioma
  12. Sarcomatoid mesothelioma
  13. Desmoplastic mesothelioma
  14. Biphasic mesothelioma
  15. Grading
  16. Postulated cell of origin
  17. Precursor lesions
  18. Somatic genetics
  19. Genetic susceptibility (Familial cancer syndromes)
  20. Prognosis and predictive factors

I Well differentiated papillary mesothelioma

  1. Definition
  2. ICD-O code
  3. Epidemiology
  4. Etiology
  5. Localization
  6. Clinical features
  7. Macroscopy
  8. Histopathology
  9. Prognosis and predictive factors

II Localized malignant mesothelioma

  1. Definition
  2. ICD-O code
  3. Clinical features
  4. Macroscopy
  5. Histopathology
  6. Prognosis

III Adenomatoid tumour

  1. Definition
  2. ICD-O code
  3. Clinical features
  4. Macroscopy
  5. Histopathology
  6. Prognosis
  7. Prognosis and predictive factors


I Primary effusion lymphoma

  1. Definition
  2. ICD-O code
  3. Synonym
  4. Localization
  5. Clinical features
  6. Etiology
  7. Histopathology
  8. Histogenesis
  9. Somatic genetics
  10. Prognosis and predictive factors

III Pyothorax-associated lymphoma

  1. Definition
  2. Synonyms and historical annotation
  3. Epidemiology
  4. Etiology
  5. Sites of involvement
  6. Clinical features
  7. Morphology
  8. Genetic features
  9. Postulated normal counterpart
  10. Prognostic features

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Published by: Unknown - Sunday, January 20, 2013

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