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TEXTBOOK : ADVANCES IN HEMATOPOIETIC STEM CELL RESEARCH

HEMATOPOIETIC STEM CELL
Edited by Rosana Pelayo .
476 pages . 

The prospective isolation of primitive blood-forming cells along with depicting of 
transcriptional networks that control early cell fate decisions, and characterization of 
microenvironmental signals influencing differentiation pathways during normal 
hematopoiesis, have been critical to the construction of a hierarchical model for the 
hematopoietic development, that has served as a paradigm for a number of systems 
within vertebrate development. Hematopoietic stem cell research has been helpful to 
elucidate mechanisms that govern tissue regeneration, to give an insight into 
perspectives that may allow protection of the system during disease, to design lifesaving 
therapies, and to discover novel drug activities. This promising field is being 
accelerated by significant contributions in genomics, molecular biology, and 
technologies including fluorescent activated cell sorting and mouse engineering, that 
give us a more integrated view of the nature of stem cells .
This book, Advances in Hematopoietic Stem Cell Research, is devoted to current and inprogress 
scientific knowledge on basic aspects of these seminal cells and their 
therapeutic applications. The text consists of 20 chapters grouped into four sections: 1) 
Hematopoietic stem cell properties, 2) Regulation of hematopoietic stem cells, 3) 
Hematopoietic stem cells in aging and disease, and 4) Hematopoietic stem cell 
therapy.
The first section provides four comprehensive chapters on the functional 
characteristics and biological properties that make distinctive the conspicuous 
population of hematopoietic stem cells, including multipotency, self-renewal, 
quiescence and novel surface markers. Five chapters in the second section contain 
powerful information about intrinsic and extrinsic factors that determine cell fates in 
early development. The authors have discussed cellular and molecular aspects of the
hematopoietic microenvironment within the bone marrow, and progress in searching 
of procedures to make the expansion of truly stem cells possible . Behavior of the stem 
and progenitor cells in aging and during disease is analyzed in the third section of this 
text, which highlights recent achievements in unraveling the role of primitive cells in 
the pathogenesis of hematological malignancies like leukemia.
Finally, to provide a comprehensive overview of the advancements in therapeutic 
applications of hematopoietic stem cells, a fourth section with five chapters addresses 
special interest, has been the evaluation of quality and potency of stem and progenitor 
cells for therapy purposes. Substantial efforts to assemble the bridge between basic 
research and clinical applications are currently being recorded worldwide, and their 
review in this section may increase the interest for the book.
It is hoped that Advances in Hematopoietic Stem Cell Research will prove to be an 
enjoyable read and that it contributes to this area of Modern Medicine. This book is in 
effect a compilation of the latest advances resulted from the participation of 
distinguished and dedicated authors, experts in the field, to whom I am extremely 
thankful. I would like to acknowledge the terrific contribution of Maja Bozicevic in the 
professional editing of the book.

Rosana Pelayo
Oncology Research Unit, Oncology Hospital,
Mexican Institute for Social Security, Mexico City,
Mexico

CONTENTS :

Part 1 of the textbook : Hematopoietic Stem Cell Properties 1


Chapter 1 Networks Establishing Hematopoietic 
Stem Cell Multipotency and Self-Renewal 3
Eliana Abdelhay, Luciana Pizzatti and Renata Binato

Chapter 2 Regulation of Hematopoietic Stem Cell Fate: 
Self-Renewal, Quiescence and Survival 39
Yasushi Kubota and Shinya Kimura

Chapter 3 Transcriptional Quiescence of Hematopoietic Stem Cells 61
Rasmus Freter

Chapter 4 Markers for Hematopoietic Stem Cells: 
Histories and Recent Achievements 77
Takafumi Yokota, Kenji Oritani, Stefan Butz, Stephan Ewers, Dietmar Vestweber and Yuzuru Kanakura

Part 2 of the textbook :  Regulation of Hematopoietic Stem Cells 89


Chapter 5 Interferon Regulatory Factor-2 Regulates 
Hematopoietic Stem Cells in Mouse Bone Marrow 91
Atsuko Masumi, Shoichiro Miyatake, Tomoko Kohno and Toshifumi Matsuyama

Chapter 6 Regulation of Tyrosine Kinase 
Signaling by Cbl in Hematopoietic Stem Cells 113
Mayumi Naramura

Chapter 7 The Hypoxia Regulatory System in 
Hematopoietic Stem Cells 133
Keiyo Takubo

Chapter 8 Skeletogenesis and the Hematopoietic Niche 147
Elizabeth Sweeney and Olena Jacenko

Chapter 9 Molecular Mechanisms Underlying Bone 
Marrow Homing of Hematopoietic Stem Cells 185
Aysegul Ocal Sahin and Miranda Buitenhuis

Chapter 10 Searching for the Key to 
Expand Hematopoietic Stem Cells 205
Jeanne Grosselin, Karine Sii-Felice, Philippe Leboulch and Diana Tronik-Le Roux

Part 3 of the textbook :  Hematopoietic Stem Cells in Aging and Disease 245


Chapter 11 Insights Into Stem Cell Aging 247
A. Herrera-Merchan, I. Hidalgo, L. Arranz and S. Gonzalez

Chapter 12 Hematopoietic Stem Cell in 
Acute Myeloid Leukemia Development 261
Sérgio Paulo Bydlowski and Felipe de Lara Janz

Chapter 13 From HSC to B-Lymphoid Cells in 
Normal and Malignant Hematopoiesis 277
Rosana Pelayo, Elisa Dorantes-Acosta, Eduardo Vadillo and Ezequiel Fuentes-Pananá

Chapter 14 Distribution of SDF1-3’A, GNB3 C825T and MMP-9 C-1562T 
Polymorphisms in HSC CD34+ from Peripheral Blood of Patients with Hematological Malignancies 299
Ben Nasr Moufida and Jenhani Faouzi

Chapter 15 Hematopoietic Derived Fibrocytes: 
Emerging Effector Cells in Fibrotic Disorders 317
Carolina García-de-Alba, Moisés Selman and Annie Pardo

Part 4 of the textbook :  Hematopoietic Stem Cell Therapy 345


Chapter 16 Hematopoietic Stem Cells Therapeutic Applications 347
Carla McCrave

Chapter 17 Hematopoietic Stem Cell Potency for 
Cellular Therapeutic Transplantation 383
Karen M. Hall, Holli Harper and Ivan N. Rich

Chapter 18 Detection of CMV Infection in 
Allogeneic SCT Recipients: The Multiple Assays 407
Pilar Blanco-Lobo, Omar J. BenMarzouk-Hidalgo and Pilar Pérez-Romero

Chapter 19 Bone Marrow Derived Pluripotent 
Stem Cells in Ischemic Heart Disease: Bridging the
Gap Between Basic Research and Clinical Applications 425
Ahmed Abdel-Latif, Ewa Zuba-Surma and Mariusz Z. Ratajczak

Chapter 20 Gene Therapy of Hematopoietic and 
Immune Systems: Current State and Perspectives 441
Maria Savvateeva, Fedor Rozov and Alexander Belyavsky .


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