Open Access Medical Books



Edited by Gerhard Hamilton .

702 pages .
Open Access . 

“Advances in Prostate Cancer” is an addition to the InTech collection of three previous books about prostate cancer and aims at providing a comprehensive overview of specific
aspects of the latest research and current knowledge relating to this tumor entity to 
scientists and clinicians. For this purpose a series of research articles, clinical investigations 
and reviews that deal with a wide range of relevant aspects pertinent to the epidemiology, diagnosis, patient care, treatment and basic biology of prostate cancer were included.
Thereby this book aptly adds to the other InTech titles in the field of oncology, that describe advances in cancer therapy, diagnosis and treatment of various cancers with reference to the cancer stem cell concept.
The numerous participating authors of this book shared their expertise in epidemiology and etiology, as well as supportive care, which comprises the handling of psychological challenges and effects of physiotherapy in coping with the consequences of prostate cancer treatment. State-of the-art radiation therapy is moreover discussed as well as the significance of testosterone and PSA measurements, the latter in form of a novel internet “App” that helps to interpret the time course of the marker determinations on the outcome.
After many years of limited means to treat advanced prostate cancer several new agents such as CYP17 inhibitors and new cytotoxic drugs, as well as a cancer vaccine, became available, which poses new questions in regard to patient selection and appropriate choice of medical care. These topics comprehensively discussed in several chapters are supplemented by a review of the current state of intermittent androgen suppression versus continuous hormone ablation. These chapters are complemented by a number of discussions on the some characteristics of the cell biology of prostate cancer, including cancer stem cells, inflammatory processes, roles of androgen receptor and diverse non-androgen gene transcripts and, furthermore, cell adhesion proteins. This book is therefore destined to all cancer researchers and therapists who intend to understand the current status of cell biology  and treatment of prostate cancer.
As editor of this book, I would like to acknowledge the significant efforts made by all of the  contributing authors for their excellent work as well as the entire Intech editorial team in  publishing of this volume. I would like to dedicate this book to the “Ludwig Boltzmann  Society” and, in particular, to Prof. Dr. Gerhard Baumgartner whose long-standing support  has allowed for the successful realization of many scientific projects. Last but not least, I  would like to thank my wife for her personal support and great patience at all times.

Gerhard Hamilton, PhD

Ludwig Boltzmann Cluster of Translational Oncology


Section 1 of the textbook :  Epidemiology and Etiology .

Chapter 1 Epidemiology of Prostate Cancer 3 Martin Dörr, Anne Schlesinger-Raab and Jutta Engel

Chapter 2 Is There an Infectious Agent Behind Prostate Cancer? 19 Ugo Rovigatti

Section 2  of the textbook :   Supporitve Care .

Chapter 3 Psychological and Social Factors influencing Patients’ Treatment Selection for Localised Prostate Cancer 63 
Luke A Robles, Shihning Chou, Owen J Cole, Akhlil Hamid, Amanda Griffiths and Kavita Vedhara

Chapter 4 The Role of Physiotherapy in the Pre and Post Treatment Interventions in Prostate Cancer Patients 79 Mario Bernardo Filho and Mauro Luis Barbosa Júnior

Section 3  of the textbook :   Surgical Care and Radiation Therapy .

Chapter 5 Abdominoperineal Resection: Consideration and Limitations 
of Prostate Cancer Screening and Prostate Biopsy 105 Zachary Klaassen, Ray S. King, Kelvin A. Moses, Rabii Madi and Martha K. Terris

Chapter 6 Radiation Therapy for Prostate Cancer 117 Shinji Kariya

Chapter 7 High-Dose-Rate Interstitial Brachytherapy as Monotherapy in 
One Fraction for the Treatment of Favorable Stage Prostate Cancer 145 Pedro J. Prada

Section 4 of the textbook :   Prostate Cancer Markers .

Chapter 8 Testosterone Measurement and Prostate Cancer 157 
Tine Hajdinjak

Chapter 9 Describing Prostate Cancer Dynamics: Second Look at PSADoubling 
Time and PSA-Specific Growth Rate 177 Glenn Tisman

Section 5 of the textbook :   Medical Treatment .

Chapter 10 Rational Categorization of the Pipeline of New Treatments for 
Advanced Cancer – Prostate Cancer as an Example 219 Sarah M. Rudman, Peter G. Harper and Christopher J. Sweeney

Chapter 11 Novel Therapeutic Settings in the Treatment of Castration- Resistant Prostate Cancer 251 Miguel Álvarez Múgica, Jesús M. Fernández Gómez, Antonio Jalón Monzón, Erasmo Miguelez García and Francisco Valle González

Chapter 12 Steroidal CYP17 Inhibitors for Prostate Cancer Treatment: From 
Concept to Clinic 275 Jorge A. R. Salvador, Vânia M. Moreira and Samuel M. Silvestre

Chapter 13 Intermittent Androgen Suppression Therapy for Prostate 
Cancer Patients: An Update 305 Gerhard Hamilton and Gerhard Theyer

Section 6 of the textbook :   Cell Biology of Prostate Cancer .

Chapter 14 Stem Cells and Prostate Cancer 333 
Vildan Bozok Çetintaş, Burçin Tezcanlı Kaymaz and Buket Kosova

Chapter 15 Salinomycin-Induced Apoptosis in Human Prostate 
Cancer Cells 361 Hak-Jong Choi, Kwang-Youn Kim, Sun-Nyoung Yu, Sang-Hun Kim, Sung-Sik Chun, Hak-Sun Yu, Yeong-Min Park and Soon-Cheol Ahn

Chapter 16 Natural Compounds, Antioxidant and Antiandrogens in the 
Prevention of Prostate Cancer: In vivo Evidences from Murine Models and Human Clinical Studies 377 Rossano Lattanzio, Alessia Lamolinara, Mauro Piantelli and Manuela Iezzi

Chapter 17 Prostate Cancer, Inflammation and Antioxidants 401 
Marika Crohns, Tuomas Westermarck and Faik Atroshi

Chapter 18 Inflammatory Microenvironment in Prostate 
Carcinogenesis 423 Geraldine Gueron, Javier Cotignola and Elba Vazquez

Section 7 of the textbook :   Role of Androgen Receptor .

Chapter 19 Expression and Function of Stromal Androgen Receptor in 
Prostate Cancer 465
Mandeep Singh, Garrett Daniels, Yirong Li and Peng Lee

Chapter 20 Prostate Cancer Progression to Androgen Independent Disease: 
The Role of the PI3K/AKT Pathway 475 Jacqueline R Ha, Yu Hao D Huang, Amit Persad and Sujata Persad

Section 8 of the textbook :   Non-Androgen Gene Transcripts in Prostate Cancer .

Chapter 21 Non-Androgen Regulated Transcription Factors as Novel 
Potential Targets for Prostate Cancer Therapy 523 J. Nathan Davis, Adam H. Greer, Thomas Yong and Shari Meyers

Chapter 22 Trithorax Genes in Prostate Cancer 541 
Pier-Luc Clermont, Francesco Crea and Cheryl D. Helgason

Chapter 23 The Function of YY1 and Its Oncogenic Role in Prostate Cancer 565 Daniel B. Stovall and Guangchao Sui

Chapter 24 The Role of PARP Activation in Prostate Cancer 591 Luis A. Espinoza .

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Published by: younes younes - Tuesday, February 5, 2013


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