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TEXTBOOK - AMYLOIDOSIS - MECHANISMS AND PROSPECTS FOR THERAPY

AMYLOIDOSIS

Edited by Svetlana Sarantseva .

226 pages . 
Open Access .

Amyloidoses are a heterogeneous group of diverse etiology diseases. They are  characterized by an endogenous production of abnormal proteins called amyloid  proteins, which are not hydrosoluble, form depots in various organs and tissue of  animals and humans and cause dysfunctions. Twenty-seven such proteins have been  identified as amyloid precursors in humans. However, the answer why these  proteins form aggregates and cause disease is not still completely clear. At present,  there is not an effective treatment to prevent protein misfolding in these amyloid  diseases.
The aim of this book is to present an overview of different aspects of amyloidoses from  basic mechanisms and diagnosis to latest advancements in treatment.
Chapters 1 to 3 provide description and clinical features as well as molecular and  cellular mechanisms, and current strategies for treatment of AL amyloidosis and AA  amyloidosis with rheumatoid arthritis. The next two chapters are focused on  molecular mechanisms of amyloid formation. Chapter 4 elucidates influence of  intrinsic and extrinsic factors on fibril deposition in Apolipoprotein A-I associated  amyloidoses with particular emphasis on the role of the pathogenic polypeptide  named [1–93]ApoA-I. Chapter 5 examines the role of synthetic glycopolymers  mimicing glycosaminoglycans in aggregation of amyloid β-peptide, which is shown  to play central role in the pathogenesis of Alzheimer’s disease. Chapters 6 and 7  provide current methods for diagnosis and amyloid typing. More details are  discussed on the advantages and limitations of the electron microscopy in the  diagnosis of amyloidosis, particularly in early stage of disease. Chapter 8 covers the  pathogenesis, lesions and clinical syndromes encompassing various forms of amyloidosis in animals.  Finally, Chapters 9 to 12 are focused on creating models of human amyloidosis in  animals. Indeed, some animal models accurately reproduce one or several  characteristics of the pathogenesis of amyloid diseases and could be useful for  understanding the molecular and cellular mechanisms of amyloid formation and  developing novel therapeutic strategies. Several animal models are presented in the  final chapters of this book.
I would like to thank all the authors who have contributed to this book and I hope that  this book will provide useful resource in study of amyloid disease pathogenesis and  discovery of new therapeutic methods in the future.

Svetlana Sarantseva
Petersburg Nuclear Physics Institute, Russian Academy of Sciences
Russia
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CONTENTS OF THE TEXTBOOK :


Chapter 1 Current and New Perspectives on the 
Molecular and Cellular Mechanisms of Amyloid
Formation and Toxicity in Light Chain Amyloidosis 1 Ara Celi Di Costanzo and Marina Ramirez-Alvarado

Chapter 2 Amyloid A Amyloidosis 
Secondary to Rheumatoid Arthritis 23 Tadashi Nakamura

Chapter 3 Diagnosis and Treatment of AA Amyloidosis 
with Rheumatoid Arthritis: State of the Art 43 Takeshi Kuroda, Yoko Wada and Masaaki Nakano

Chapter 4 Apolipoprotein A-I Associated 
Amyloidoses: The Intriguing Case of a Natively Unfolded Protein Fragment 63 Daria Maria Monti, Renata Piccoli and Angela Arciello

Chapter 5 Interaction and Aggregation of Amyloid  
Peptide with Multivalent Sulfonated Sugar 85 Yoshiko Miura and Tomohiro Fukuda

Chapter 6 Laboratory Methods for the 
Diagnosis of Hereditary Amyloidoses 101 S. Michelle Shiller, Ahmet Dogan and W. Edward Highsmith, Jr.

Chapter 7 Electron Microscopy in the Diagnosis of Amyloidosis 121 Tosoni A., Barbiano di Belgiojoso G. and Nebuloni M.

Chapter 8 Amyloidosis in Domestic Animals: Pathology, Pathogenesis,
Gross and Microscopic Lesions and Clinical Findings 149 Moges Woldemeskel

Chapter 9 Mouse Models to Study Systemic Amyloidoses: Is Prion-Like 
Transmission a Common Pathogenic Mechanism? 163 Keiichi Higuchi, Xiaoying Fu, Pengyao Zhang, Jinko Sawashita, Beiru Zhang, Jinze Qian, Wang Yaoyong and Masayuki Mori

Chapter 10 Transthyretin Amyloidosis in Aged Vervet 
Monkeys, as a Candidate for the Spontaneous Animal Model of Senile Systemic Amyloidosis 181 Shinichiro Nakamura, Mitsuharu Ueda, Naohide Ageyama, Yukio Ando and Ryuzo Torii


Chapter 11 Amyloidosis Associated to Leishmania Infection in Murine Model 191 Ana Lucia Abreu-Silva, Gabriel Xavier-Silva, Marlise Neves Milhomem, Mylena Andrea Oliveira Torres and Kátia da Silva Calabrese

Chapter 12 Modeling Amyloid Diseases in Fruit Fly Drosophila Melanogaster 199 Svetlana Sarantseva and Alexander Schwarzman .


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