Open Access Medical Books



Edited by Tong Liu . 

246 pages . 

Atrial fibrillation is a rapidly evolving epidemic associated with increased cardiovascular morbidity and mortality, and its prevalence has increased during the past few decades. In the past few years, the recent understanding of the diverse mechanisms of this arrhythmia has led to the improvement of our therapeutic strategies. However, many clinicians have still felt the frustration in management of this commonly encountered arrhythmia.
This book contains a spectrum of different topics from bench to bedside in atrial fibrillation. We try to introduce the most recent advancement of mechanisms and treatment of AF including genetics, calcium signaling, thrombogenesis, signal analysis, upstream therapies focus on renin-angiotensin-aldosterone system inhibitors, antioxidants and n-3 polyunsaturated fatty acids, and anticoagulation issues. I strongly believe that scientists, cardiologists and electrophysiologists will find this book very informative and useful. The references cited in each chapter will definitely act as additional source of information for readers.
I am grateful to the all the authors who contributed to this book with their valuable experience.
I also appreciate the great help from InTech editorial office, Ms. Mirna Cvijic and Mr. Dejan Grgur, who guided me through the publication process step by step. I would also like to thank for the important contributions from the co-editors of this book – Prof. Guangping Li, my mentor, and Dr. Panagiotis Korantzopoulos, my best friend who guided me to explore the wonderful world of arrhythmia. Finally, special thanks to my family – wife, Lijian, and son, Yujie, who provided continuous inspiration and support to my work.

Tong Liu, MD, PhD
Department of Cardiology, Tianjin Institute of Cardiology
Second Hospital of Tianjin Medical University, Tianjin
People’s Republic of China


Section 1 of the textbook : Pharmacological Management .

1 Atrial Fibrillation and the 
Renin-Angiotensin-Aldosterone System 3 Stefano Perlini, Fabio Belluzzi, Francesco Salinaro and Francesco Musca

2 Antioxidant Therapies in the Prevention and Treatment of 
Atrial Fibrillation 29 Tong Liu, Panagiotis Korantzopoulos and Guangping Li

3 Effect of CD3+ T-Lymphocyte and n-3 Polyunsaturated Fatty 
Acids on the Diagnosis or Treatment of Atrial Fibrillation 45 Qiang-Sun Zheng, Hong-Tao Wang, Zhong Zhang, Jun Li, Li Liu and Bo-yuan Fan

Section 2 of the textbook : Mechanisms .

4 New Candidate Genes in Atrial Fibrillation Polymorphisms of 
the Alpha 2-Beta-Adrenoceptor and the Endothelial NO Synthase Genes in Atrial Fibrillation of Different Etiological Origins 59 Svetlana Nikulina, Vladimir Shulman, Ksenya Dudkina, Anna Chernova and Oksana Gavrilyuk

5 Voltage-Independent Calcium Channels, Molecular Sources of 
Supraventricular Arrhythmia 79 Paul E. Wolkowicz, Patrick K. Umeda, Ferdinand Urthaler and Oleg F. Sharifov

6 Thrombogenesis in Atrial Fibrillation 127 
Hanan Ahmed GalalAzzam

Section 3 of the textbook : Signal Analysis .

7 Applications of Signal Analysis to Atrial Fibrillation 155 
José Joaquín Rieta and Raúl Alcaraz

8 The Contribution of Nonlinear Methods in the Understanding 
of Atrial Fibrillation 181 Raúl Alcaraz and José Joaquín Rieta

Section 4 of the textbook : Anticoagulation Therapy .

9 New Oral Anticoagulants in Atrial Fibrillation 207 
Lucía Cid-Conde and José López-Castro

10 Anticoagulant Therapy in Patients with Atrial Fibrillation and 
Coronary Artery Disease 229 Atila Bitigen and Vecih Oduncu .

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Published by: Unknown - Thursday, February 28, 2013


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