Open Access Medical Books


Edited by James Chan .
402 pages . 

Autoimmune disease represents a group of more than 60 different chronic autoimmune 
diseases that affect approximately 6% of the population. It is the third major category of 
illness in the United States and many industrialized countries, following heart disease 
and cancer. Autoimmune diseases arise when one’s immune system actively targets and 
destroys self tissue resulting in clinical disease. Common examples include Systemic 
Lupus Erythematosus, Type 1 Diabetes, Rheumatoid Arthritis and Multiple Sclerosis.
While different in clinical features and may involve different organs, the underlying 
mechanism is the failure of immune tolerance of the adaptive immune system.
The immune system is designed to protect us from foreign pathogens such as viruses 
and bacteria, and in particular the adaptive immune system mounts antigen specific 
attack on targets. The underlying mechanism that enables recognition and responses to 
unknown targets is the generation of antigen receptors on lymphocytes through the 
process of random gene recombination. A negative consequence of this process is the 
generation of self-reactive receptors capable of responding to self-antigens and causing 
pathology. Although a number of mechanisms such as clonal deletion and other immune 
regulations are in place to eliminate or counter the action of these self-reactive clones, a 
number of known factors can interfere and breakdown these regulatory mechanisms.
This book entitled “Autoimmune Diseases - Contributing Factors, Specific Cases of 
Autoimmune Diseases, and Stem Cell and Other Therapies” aims to present the latest 
knowledge and insights regarding the different contributing factors and their 
interplay, discussions on several autoimmune diseases and their case studies, and 
therapeutic treatments, including stem cell, for autoimmune diseases. The quest in this 
field of research is to better understand the underlying factors and pathways leading 
to autoimmune diseases and derive proper treatment for each disease.
I believe this book will provide an invaluable resource for researchers and students in 
the field of autoimmunity/immune tolerance, and also for a general readership to 
better understanding autoimmune diseases.

James Chan Ph.D.
Department of Medicine, Monash University,


Section 1 of the textbook : Pathogenesis of Autoimmune Disease 1

Chapter 1 Current Theories for Multiple 
Sclerosis Pathogenesis and Treatment 3
Marcus Muller, Rachael Terry, Stephen D. Miller and Daniel R. Getts

Chapter 2 Immunologic and Genetic 
Factors in Type 1 Diabetes Mellitus 25
Ahmad Massoud and Amir Hossein Massoud

Chapter 3 Balancing Pro- and Anti-Inflammatory CD4+ T Helper Cells in the Intestine 51
Nicola Gagliani and Samuel Huber

Chapter 4 T Cell Metabolism in Autoimmune Diseases 77
Dan Li, Miranda Piccioni, Zhimei Gao, Chen Chen, Zuojia Chen, Jia Nie, Zhao Shan, Yangyang Li, Andy Tsun and Bin Li

Chapter 5 Apoptosis and Autoimmune Disorders 99
Reginald Halaby

Section 2 of the textbook :  Specific Autoimmune Diseases 117

Chapter 6 Immune Complex Deposits as a 
Characteristic Feature of Mercury-Induced SLE-Like Autoimmune Process in Inbred and Outbred Mice 119
Alla Arefieva, Marina Krasilshchikova and Olga Zatsepina

Chapter 7 Celiac and Inflammatory Bowel Diseases in 
Children with Primary Humoral Immunodeficiency 151
Anna Pituch-Noworolska and Katarzyna Zwonarz

Chapter 8 Central Nervous System Resident Cells in 
Neuroinflammation: A Brave New World 173
J.P.S. Peron, D. Oliveira, W. N. Brandão, A. Fickinger, A. P. Ligeiro de Oliveira, L. V. Rizzo and N.O.S. Câmara

Chapter 9 Autoimmune Encephalitis in Rural Central Illinois 193
Reuben Mari Valenzuela, Paayal Patel and Jorge C. Kattah

Chapter 10 The Role of the Antigen GAD 65 in Diabetes Mellitus Type 1: A Molecular Analysis 207
Marco Wiltgen and Gernot P. Tilz

Section 3 of the textbook :  Stem Cell and Other Therapies for Autoimmune Disease 251

Chapter 11 New Therapeutic Challenges in Autoimmune Diseases 253
Eun Wha Choi

Chapter 12 Stem Cell Therapies for Type I Diabetes 281
Jesus Ciriza and Jennifer O. Manilay

Chapter 13 Stem Cell-Based Cellular 
Therapy in Rheumatoid Arthritis 319
Rizwanul Haque, Fengyang Lei and Jianxun Song

Chapter 14 Biologic Treatment in Rheumatoid Arthritis 343
Katerina Chatzidionysiou

Chapter 15 Biologic Therapy in Patients with 
Juvenile Idiopathic Arthritis – A Unique Single Centre Experience at the Scientific-Research Pediatric Centre in the Russian Federation 357
A.A. Baranov, E.I. Alexeeva, L.S. Namazova-Baranova, T.M. Bzarova, S.I. Valiyeva,
R.V. Denisova, K.B. Isayeva, A.M. Chomakhidze, E.G. Chistyakova, T.V. Sleptsova, E.V. Mitenko, E.I. Zelikovich, G.V. Kurilenko, E.L. Semikina, A.V. Anikin, A.M. Stepanchenko, N.I. Taybulatov, A.V. Starikova, I.V. Dvoryakovskiy and M.V. Ryazanov .

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Published by: Unknown - Sunday, February 3, 2013


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