Open Access Medical Books

TEXTBOOK : CURRENT INSIGHTS IN POLLEN ALLERGENS

POLLEN ALLERGENS

Edited by José C. Jiménez-López .

132 pages . 
Open Access .

Pollen allergy is an important public problem and one of the most common causes of chronic ill health in the western societies. More than 25% of the population suffers from IgE-mediated allergies (including children and adults) which therefore represent a major challenge of our society, particularly because untreated allergy often progresses to severe disabling forms of disease. This allergic disease has increased in prevalence during the past decades and a major increase has been predicted.
Today allergen-specific immunotherapy is being established as the only allergenspecific and disease-modifying approach toward the treatment for IgE-mediated allergies and has long lasting effects. Up until now, commonly used treatments have been focused on relief of the clinical symptoms to alleviate allergic inflammation rather than underlying immune mechanisms, i.e. antihistamine and topical corticosteroids. In addition, conventional immunotherapy involves administration of natural allergen extracts containing mixture of undefined components with potential to induce a life-threatening anaphylactic response and new IgE-mediated reactivity and/or sensitizations to previously non-exposes allergens.
At present, there is not universal cure for pollen allergy, and the disease can only be managed by allergens avoidance or treatment of symptoms. However, there is exciting new knowledge as these presented in this book “the cultivar issues”, which may help in the improvement of clinical trial, diagnosis and development of potential new therapies.
Researchers in the field are working hard to understand the mechanisms of allergy, and the disease-causing allergens are being characterized in great detail down to their molecular structures and cellular and physiological functions. Advances in molecular biology have led to an exponential increase in our understanding of molecular pathways involved in the manifestation of type 1 allergy symptoms, which also has pave the road for a significant advance in the development of a cure or vaccine for
atopic allergic diseases.
Biochemical and molecular approaches together with computational biology, especially the informatics tools for allergen epitopes identification, structural characterization for designing allergy vaccines, have provided the knowledge to resolve structural features of allergen molecules and develop safer form of specific
immunotherapy. Various others strategies and approaches are ongoing research programs including cellular and immunological mechanisms of therapy, genetic modification of allergens, hypoallergenic proteins chimera production, DNA vaccines, anti-IgE therapy, different routes of vaccine delivery, reduction of the allergen proteins content in plant-derived food by using RNAi technology, improved production
systems for recombinant allergens.
Having this global vision, it seems that we are driving in the right direction to be able developing new and rational forms of diagnosis and therapy strategies. This way holds promise for curing pollen allergy sufferers and eventually may allow real prophylactic vaccination against allergy, i.e. tailored vaccines, or these based in pollen allergen proteins from defined cultivars.


Dr. José C. Jiménez-López
Purdue University,
USA
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CONTENTS OF THE TEXTBOOK :


  1 Pollen Allergenicity is Highly Dependent on the Plant 
Genetic Background: The “Variety”/“Cultivar” Issues 1 Juan de Dios Alché, Adoración Zafra, Jose Carlos Jiménez-López, Sonia Morales, Antonio Jesús Castro, Fernando Florido and María Isabel Rodríguez-García

  2 Clustering of Olive Pollens into Model Cultivars 
on the Basis of Their Allergenic Content 27 Sonia Morales, Antonio Jesús Castro, Carmen Salmerón, Francisco Manuel Marco, María Isabel Rodríguez-García and Juan de Dios Alché

  3 Detection and Quantitation of Olive Pollen Allergen 
Isoforms Using 2-D Western Blotting 41 Krzysztof Zienkiewicz, Estefanía García-Quirós, Juan de Dios Alché, María Isabel Rodríguez-García and Antonio Jesús Castro

  4 Involvement of Climatic Factors in 
the Allergen Expression in Olive Pollen 57 Sonia Morales, Antonio Jesús Castro, María Isabel Rodríguez-García and Juan de Dios Alché

  5 Differential Immune-Reactivity and Subcellular Distribution 
eveal the Multifunctional Character of Profilin in Pollen as Major Effect of Sequences Polymorphism 71 Jose C. Jimenez-Lopez, Sonia Morales, Dieter Volkmann, Juan D. Alché and María I. Rodriguez-Garcia

  6 Efficacy of Flavonoids for Patients with 
Japanese Cedar Pollinosis 103 Toshio Tanaka .


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Published by: younes younes - Wednesday, February 20, 2013

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