Open Access Medical Books


Edited by Michael S. Kallos .
518 pages . 

Embryonic stem cells have immense therapeutic potential, but for cell therapy these 
pluripotent cells will have to be differentiated towards cells of interest before 
transplantation. Controlled, robust differentiation processes will require knowledge of 
the signalling pathways and mechanisms which will obviously be unique for each
differentiated cell type. There are a tremendous variety of approaches and techniques, 
and this book, Embryonic Stem Cells - Differentiation and Pluripotent Alternatives and its 
companion, Embryonic Stem Cells - Basic Biology to Bioengineering, serve as a snapshot of 
many of the activities currently underway on a number of different fronts.
This book is divided into eight parts and provides examples of the many tissue types 
that embryonic stem cells are being pushed towards, as well as alternative sources for 
pluripotent stem cells....

Michael S. Kallos
Pharmaceutical Production Research Facility (PPRF),
Schulich School of Engineering, University of Calgary, Alberta,

Department of Chemical and Petroleum Engineering,
Schulich School of Engineering, University of Calgary, Alberta,


Part 1 of the textbook : General Differentiation 1

Chapter 1 Role of Signaling Pathways and Epigenetic 
Factors in Lineage Determination During
Human Embryonic Stem Cell Differentiation 3
Prasenjit Sarkar and Balaji M. Rao

Chapter 2 Bioactive Lipids in Stem Cell Differentiation 33
Erhard Bieberich and Guanghu Wang

Chapter 3 Retinoid Signaling is a Context-Dependent 
Regulator of Embryonic Stem Cells 55
Zoltan Simandi and Laszlo Nagy

Part 2 of the textbook :  Neural and Retinal Differentiation 79

Chapter 4 Pluripotent Stem Cells as an In Vitro 
Model of Neuronal Differentiation 81
Irina Kerkis, Mirian A. F. Hayashi, Nelson F. Lizier, Antonio C. Cassola, Lygia V. Pereira and Alexandre Kerkis

Chapter 5 Characterization of Embryonic Stem (ES) 
Neuronal Differentiation Combining Atomic Force, Confocal and DIC Microscopy Imaging 99
Maria Elisabetta Ruaro, Jelena Ban and Vincent Torre

Chapter 6 Oligodendrocyte Fate Determination 
in Human Embryonic Stem Cells 119
Siddharth Gupta, Angelo All and Candace Kerr

Chapter 7 Stem-Cell Therapy for Retinal Diseases 135
Rubens Camargo Siqueira

Part 3 of the textbook :  Cardiac and Other Myogenic Differentiation 149

Chapter 8 Transcriptional Networks 
of Embryonic Stem Cell-Derived Cardiomyogenesis 151
Diego Franco, Estefania Lozano-Velasco and Amelia Aránega

Chapter 9 Human Pluripotent Stem Cells 
in Cardiovascular Research and Regenerative Medicine 169
Ellen Poon, Chi-wing Kong and Ronald A. Li

Chapter 10 Human Pluripotent Stem Cell-Derived Cardiomyocytes: 
Maturity and Electrophysiology 185
Ville Kujala, Mari Pekkanen-Mattila and Katriina Aalto-Setälä

Chapter 11 Maintenance Of Calcium Homeostasis 
in Embryonic Stem Cell-Derived Cardiomyocytes 205
Iek Chi Lo, Chun Kit Wong and Suk Ying Tsang

Chapter 12 Myogenic Differentiation of ES Cells for Therapies 
in Neuromuscular Diseases: Progress to Date 227
Camila F. Almeida, Danielle Ayub-Guerrieri and Mariz Vainzof

Part 4 of the textbook :  Endothelial Differentiation 243

Chapter 13 Dissecting the Signal Transduction Pathway 
that Directs Endothelial Differentiation Using Embryonic Stem CellDerived Vascular Progenitor Cells 245
Kyoko Kawasaki and Keiji Miyazawa

Chapter 14 Endothelial Differentiation of Embryonic Stem Cells 267
Peter Oettgen

Part 5 of the textbook :  Hepatic Differentiation 277

Chapter 15 Stem Cells for HUMAN Hepatic Tissue Engineering 279
N.I. Nativ, M.A. Ghodbane, T.J. Maguire, F. Berthiaume and M.L. Yarmush

Chapter 16 Hepatic Differentiation of Human Embryonic and Induced 
Pluripotent Stem Cells for Regenerative Medicine 303
Toshio Miki

Part 6 of the textbook :  Osteogenic Differentiation 321

Chapter 17 Osteogenesis from Pluripotent Stem Cells:
Neural Crest or Mesodermal Origin? 323
Kevin C. Keller and Nicole I. zur Nieden

Part 7 of the textbook :  Pluripotent Alternatives – Induced Pluripotent Stem Cells (iPSCs) 349

Chapter 18 The Past, Present and Future of 
Induced Pluripotent Stem Cells 351
Koji Tanabe and Kazutoshi Takahashi

Chapter 19 New Techniques in the Generation 
of Induced Pluripotent Stem Cells 373
Raymond C.B. Wong, Ellen L. Smith and Peter J. Donovan

Chapter 20 Generation of ICM-Type Human iPS Cells 
from CD34+ Cord Blood Cells 399
Naoki Nishishita, Noemi Fusaki and Shin Kawamata

Chapter 21 Modelling of Neurological Diseases 
Using Induced Pluripotent Stem Cells 413
Oz Pomp, Chen Sok Lam, Hui Theng Gan, Srinivas Ramasamy and Sohail Ahmed

Part 8 of the textbook :  Pluripotent Alternatives - Other Cell Sources 431

Chapter 22 Very Small Embryonic/Epiblast-Like Stem Cells (VSELs) 
Residing in Adult Tissues and Their Role in Tissue Rejuvenation and Regeneration 433
Dong-Myung Shin, Janina Ratajczak, Magda Kucia and Mariusz Z. Ratajczak

Chapter 23 Multipotent Dental Stem Cells: 
An Alternative Adult Derived Stem Cell Source for Regenerative Medicine 451
Tammy Laberge and Herman S. Cheung

Chapter 24 Pluripotent Stem Cells from Testis 473
Sandeep Goel and Hiroshi Imai

Chapter 25 Amniotic Fluid Stem Cells 493
Gianni Carraro, Orquidea H. Garcia, Laura Perin, Roger De Filippo and David Warburton . 

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Published by: Unknown - Sunday, February 3, 2013


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