Open Access Medical Books



Edited by Terry Lichtor .

648 pages . 

Although technical advances have resulted in marked improvements in the ability to diagnose and surgically treat primary and metastatic brain tumors, the incidence and mortality rates of these tumors is increasing. Particularly affected are young adults and the elderly. The present standard treatment modalities following surgical resection including cranial irradiation and systemic or local chemotherapy each have limited efficacy and serious adverse side effects. Furthermore the relatively few long-term survivors are inevitably left with cognitive deficits and other disabilities. The difficulties in treating malignant gliomas can be attributed to several factors. Glial tumors are inherently resistant to radiation and standard cytotoxic chemotherapies. The existence of blood-brain and blood-tumor barriers impede drug delivery to the tumor and adjacent brain infiltrated with tumor. In addition the low therapeutic index between tumor sensitivity and toxicity to normal brain severely limits the ability to systemically deliver therapeutic doses of drugs or radiation therapy to the tumor. New treatment strategies for the management of patients with these tumors are urgently needed.
A number of emerging treatment strategies currently being developed are outlined in this book. In particular advances in the molecular biology of brain tumors including the evolution of stem cell biology, microRNAs along with angiogenesis and tumor invasion patterns are reviewed in this book. Another emerging strategy in the treatment of brain tumors involves the stimulation of an immunologic response against the neoplastic cells. Although in most instances proliferating tumors do not provoke anti-tumor cellular immune responses,
the hope is that the immune system can be called into play to destroy malignant cells. In addition the tumors display a particular resistance to radiation therapy and chemotherapy.
Some of the mechanisms that enable antigenic neoplasms to escape host immunity or develop a resistance to radiation therapy or chemotherapy are reviewed in this book. Hopefully this information coupled with advances in the understanding of the pathophysiology and molecular biology of brain tumors which are outlined in this book will translate into novel therapeutic treatment strategies with an emphasis on molecular targeting that should lead to the prolongation of survival without a decline in cognitive functions or other side effects in patients with brain tumors.

Dr. Terry Lichtor
Rush Medical College,
Department of Neurosurgery,
Chicago, United States


Section 1 of the textbook : Angiogenesis and Tumor Invasion .

1 Brain Tumor Invasion and Angiogenesis 3
Almos Klekner

2 Gliomas Biology: Angiogenesis and Invasion 37
Maria Caffo, Valeria Barresi, Gerardo Caruso, Giuseppe La Fata, Maria Angela Pino, Giuseppe Raudino, Concetta Alafaci and Francesco Tomasello

3 Hypoxia, Angiogenesis and Mechanisms for Invasion of 
Malignant Gliomas 105
Paula Province, Corinne E. Griguer, Xiaosi Han, Nabors Louis B. and Hassan Fathallah Shaykh

4 Brain Tumor–Induced Angiogenesis: Approaches and 
Bioassays 125
Stefan W. Hock, Zheng Fan, Michael Buchfelder, Ilker Y. Eyüpoglu and Nic E. Savaskan

Section 2 of the textbook : Immunotherapy .

5 IGF-I Antisense and Triple-Helix Gene Therapy of 
Glioblastoma 149
Jerzy Trojan and Ignacio Briceno

6 Using REMBRANDT to Paint in the Details of Glioma Biology: 
Applications for Future Immunotherapy 167
An Q. Dang, Neil T. Hoa, Lisheng Ge, Gabriel Arismendi Morillo, Brian Paleo, Esteban J. Gomez, Dayeon Judy Shon, Erin Hong, Ahmed M. Aref and Martin R. Jadus

Section 3 of the textbook : Molecular Biology of Brain Tumors and Associated Therapeutic Implications .

7 From Gliomagenesis to Multimodal Therapeutic Approaches 
into High-Grade Glioma Treatment 203
Giuseppe Raudino, Maria Caffo, Gerardo Caruso, Concetta Alafaci, Federica Raudino, Valentina Marventano, Alberto Romano, Francesco Montemagno, Massimo Belvedere, Francesco Maria Salpietro, Francesco Tomasello and Anna Schillaci

8 Dipeptidyl Peptidase-IV and Related Proteases in 
Brain Tumors 235
Petr Busek and Aleksi Sedo

9 Apoptotic Events in Glioma Activate Metalloproteinases and 
Enhance Invasiveness 271
Albert Magro

10 The Distribution and Significance of IDH Mutations 
in Gliomas 299
Marta Mellai, Valentina Caldera, Laura Annovazzi and Davide Schiffer

11 Deregulation of Cell Polarity Proteins in Gliomagenesis 343
Khamushavalli Geevimaan and Phanithi Prakash Babu

12 Aquaporin, Midkine and Glioblastoma 355
Mine Ergüven

13 Porphyrin Synthesis from 5-Aminolevulinic Acid in Patients 
with Glioma 377
Satoshi Utsuki, Hidehiro Oka, Kiyotaka Fujii, Norio Miyoshi, Masahiro Ishizuka, Kiwamu Takahashi and Katsushi Inoue

14 Mechanisms of Aggressiveness in Glioblastoma: Prognostic and 
Potential Therapeutic Insights 387
Céline S. Gonçalves, Tatiana Lourenço, Ana Xavier-Magalhães, Marta Pojo and Bruno M. Costa

Section 4 of the textbook : Novel Anticancer Agents .

15 A Rational for Novel Anti-NeuroOncology Drugs 435
Lee Roy Morgan

16 DNA-PK is a Potential Molecular Therapeutic Target for 
Glioblastoma 459
P. O. Carminati, F. S. Donaires, P. R. D. V. Godoy, A. P. Montaldi, J. A. Meador, A.S. Balajee, G. A. Passos and E. T. Sakamoto-Hojo

Section 5 of the textbook : MicroRNAs .

17 Evolvement of microRNAs as Therapeutic Targets for 
Malignant Gliomas 483
Sihan Wu, Wenbo Zhu and Guangmei Yan

18 MicroRNAs Regulated Brain Tumor Cell Phenotype and Their 
Therapeutic Potential 497
Chunzhi Zhang, Budong Chen, Xiangying Xu, Baolin Han, Guangshun Wang and Jinhuan Wang

Section 6 of the textbook : Pediatric Brain Tumors .

19 Carbonic Anhydrase IX in Adult and Pediatric 
Brain Tumors 533
Kristiina Nordfors, Joonas Haapasalo, Hannu Haapasalo and Seppo Parkkila

20 New Molecular Targets and Treatments for Pediatric 
Brain Tumors 555
Claudia C. Faria, Christian A. Smith and James T. Rutka

Section 7 of the textbook : Radioresistance of Brain Tumors .

21 In silico Analysis of Transcription Factors Associated to 
Differentially Expressed Genes in Irradiated Glioblastoma Cell Lines 577
P. R. D. V. Godoy, S. S. Mello, F. S. Donaires, E. A. Donadi, G. A. S. Passos and E. T. Sakamoto-Hojo

Section 8 of the textbook : Stem Cells .

22 Brain Tumor Stemness 603
Andrés Felipe Cardona and León Darío Ortíz

23 Nestin: Neural Stem/Progenitor Cell Marker in Brain Tumors 623
Yoko Matsuda, Hisashi Yoshimura, Taeko Suzuki and Toshiyuki Ishiwata .

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Published by: Unknown - Thursday, February 28, 2013


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