Open Access Medical Books



Edited by Taner Demirer .

378 pages . 
Open Access .

This book documents the increased number of stem cell related research, basic and clinical clinical applications as well as views for the future. The book covers a wide range of issues related to new developments and innovations in cell-based therapies containing basic and clinical chapters from the respected authors involved in stem cell studies and research around the world. It thereby complements and extends the basic coverage of stem cells such as immunogenetics, neuron replacement therapy, cover hematopoietic stem cells, issues related to clinical problems, advanced HLA typing, alternative donor sources as well as gene therapy that employs novel methods in this field. Clearly, the treatment of various malignancies and biomedical engineering will depend heavily on stem cells, and this book is well positioned to provide comprehensive coverage of these developments. This book will be the the main source for clinical and preclinical publications for scientists working toward cell transplantation therapies with the primary goal of replacing diseased cells with donor cells of various organs and transplanting those cells close to the injured or diseased target. With the increased number of publications related to stem cells and Cell Transplantation, we felt it was important to take this opportunity to share these new developments and innovations describing stem cell research in the cell transplantation field with our world-wide readers.
Stem cells have a unique ability; they are able to self renew limitlessly allowing them to replenish themselves as well as other cells. Another ability of stem cells is that they are able to differentiate to any cell type. A stem cell does not differentiate directly to a specialized cell, however. There are often multiple intermediate stages. A stem cell will first differentiate to a progenitor cell – a progenitor cell is similar to a stem cell, although they are limited in the number of times they can replicate and they are also restricted in which cells they can further
differentiate to. Serving as a sort of repair system for the body, they can theoretically divide without limit to replenish other cells as long as the person or animal is still alive.
When a stem cell divides, each new cell has the potential to either remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell or a brain cell.
During this last decade, the number of published articles or books investigating the role of stem cells in cell transplantation or regenerative medicine increased remarkably across all sections of the stem cell related journals. The largest number of stem cell articles was published mainly in the field of clinical transplantation, neuroscience, followed by the bone, muscle, and cartilage and hepatocytes. Interestingly, in recent years, the number of stem cell articles describing the potential use of stem cell therapy and islet transplantation in the diabetes has also slowly been increasing, even though this field of endeavor could have one of the greatest clinical and societal impacts.
It will be exciting and interesting for our readers to follow the recent developments in the field of basic and clinical aspects of stem cells and cell transplantation. Although we are close to finding pathways for stem cell therapies in many medical conditions, scientists need to be careful how they use stem cells ethically and should not rush into clinical trials without carefully investigating the side effects. Focus must be on Good Manufacturing Procedures (GMP) and careful monitoring of the long-term effects of transplanted stem cells in the host.
In conclusion, Cell Transplantation is bridging cell transplantation research in a multitude of disease models as methods and technology continue to be refined. The use of stem cells in many therapeutic areas will bring hope to many patients awaiting replacement of malfunctioning organs or repair of damaged tissue. We hope that this book will be an important tool and reference guide for all scientists worldwide who work in the field of stem cells and cell transplantation, and that it will shed light upon many important debatable issues in this field. I would like to thank all authors who contributed to this book with excellent and up-todate chapters relaying the recent developments to our readers in the field of stem cell transplantation. I would like to give a special thanks to Ana Pantar, Publishing Process Manager, and all InTech staff for their valuable contribution in making this book available.


Professor of Medicine, Hematology/Oncology
Dept. of Hematology
Ankara University Medical School
Ankara, TURKEY 


Section 1 of the textbook : Basic Aspects of Stem Cell Transplantation .

  1 Immunogenetics of Hematopoietic Stem Cell 
Transplantation 3 Amanda Vansan Marangon, Ana Maria Sell, Daniela Maira Cardozo and Jeane E. L. Visentainer

  2 The Advanced HLA Typing Strategies for Hematopoietic Stem Cell Transplantation 45 Sun Yuying and Xi Yongzhi

  3 Neuron Replacement and Brain Repair; Sex Does Matter 71 
Laurent Lecanu

  4 Potentiality of Very Small Embryonic-Like Stem Cells to Repair Myocardial Infarction 93 X. Gu, J. Gu, J.B. Sun, Y.X. Gu, L. Sun, Y. Zhang, Y. Cheng, Z.Y. Bao, F. Hang, X.M. Lu, R.S. Zhang and B.C. Li

Chapter 5 Recent Advances in Hematopoietic Stem Cell Gene Therapy 107 Toshihisa Tsuruta

Section 2 of the textbook : Clinical Aspects of Stem Cell Transplantation .

  6 Progress in Hematopoietic Stem Cell Transplantation 139 
Miroslaw Markiewicz, Malgorzata Sobczyk-Kruszelnicka, Monika Dzierzak Mietla, Anna Koclega, Patrycja Zielinska and Slawomira Kyrcz-Krzemien

  7 Current Approach to Allogeneic Hematopoietic Stem Cell Transplantation 155 Hugo F. Fernandez and Lia Perez

  8 Controversies in Autologous Stem Cell Transplantation for the 
Treatment of Multiple Myeloma 195 Bhavana Bhatnagar and Ashraf Z. Badros

  9 Proteasome Inhibition and Hematopoietic Stem Cell 
Transplantation in Multiple Myeloma 221 Helgi van de Velde and Andrew Cakana

  10 Autologous Stem Cell Transplantation for Acute Myeloid 
Leukemia 241 Pier Paolo Piccaluga, Stefania Paolini, Giovanna Meloni, Giuseppe Visani and Felicetto Ferrara

  11 Tumorablative Allogeneic Hematopoietic Stem Cell Transplantation in the Treatment of High-Risk and Refractory Leukemia — New Concepts and Clinical Practice 257 Wan-ming Da

  12 Stem Cell Transplantation in Chronic Lymphocytic Leukemia 273 Anna Gazzola, Alessandro Broccoli, Vittorio Stefoni and Pier Paolo Piccaluga

  13 Current Status of Hematopoietic Stem Cell Transplantation in 
Patients with Refractory or Relapse Hodgkin Lymphoma 289 Leylagül Kaynar, Mustafa Çetin, Ali Ünal and Taner Demirer

  14 Iron Overload and Hematopoetic Stem Cell 
Transplantation 305 Zeynep Arzu Yegin, Gülsan Türköz Sucak and Taner Demirer

  15 Sickle Cell Disease (SCD) and Stem Cell Therapy (SCT): Implications for Psychotherapy and Genetic Counselling in Africa 331 Oluwatoyin Olatundun Ilesanmi

  16 Alternative Donor Sources for Hematopoietic Stem Cell Transplantation 349 Francisco Barriga, Nicolás Rojas and Angélica Wietstruck .

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Published by: Unknown - Thursday, February 14, 2013


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