Open Access Medical Books



Edited by Peter Bright .

372 pages . 

Neuroimaging methodologies continue to develop at a remarkable rate, providing ever more sophisticated techniques for investigating brain structure and function. The scope of this book is not to provide a comprehensive overview of methods and applications but to provide a “snapshot” of current approaches using well established and newly emerging techniques. Taken together, these chapters provide a broad sense of how the limits of what is achievable with neuroimaging methods are being stretched. In cognitive neuroscience research, however, it is increasingly recognised that key theoretical debates about brain function are only likely to be resolved with reference to converging evidence from a range of methods. All neuroimaging techniques have important limitations which should always be acknowledged. For example, functional magnetic resonance imaging (fMRI) is a correlational, indirect method of measuring brain activation and interpretation of signal should always reflect this fact. Spatial resolution and sensitivity is improving with the commercial availability of ultra-high field human scanners, but a single voxel (the smallest unit of measurement) still corresponds to many thousands of individual neurons.
Haemodynamic response to input is slow (in the order of seconds) and the relationship between this function and neural activity remains incompletely understood. Furthermore, choice of image preprocessing parameters can appear somewhat arbitrary and an obvious rationale for selection of statistical thresholds, correction for multiple corrections, etc. at the analysis stage can likewise be lacking.
Therefore, to advance our knowledge about the neural bases of cognition, rigorous methodological control, well developed theory with testable predictions, and inferences drawn on the basis of a range of methods is likely to be required.....

Dr. Peter Bright
Anglia Ruskin University,
Cambridge Campus,
East Road, Cambridge
United Kingdom


Chapter 1 Functional Neuroimaging: A Historical Perspective 1
Stefano Zago, Lorenzo Lorusso, Roberta Ferrucci and Alberto Priori

Chapter 2 fMRI for the Assessment of Functional Connectivity 29
Till Nierhaus, Daniel Margulies, Xiangyu Long and Arno Villringer

Chapter 3 Functional Near-Infrared Spectroscopy (fNIRS): Principles and Neuroscientific Applications 47
José León-Carrión and Umberto León-Domínguez

Chapter 4 Measurement of Brain Function Using Near-Infrared Spectroscopy (NIRS) 75
Hitoshi Tsunashima, Kazuki Yanagisawa and Masako Iwadate

Chapter 5 Towards Model-Based Brain Imaging with Multi-Scale Modeling 99
Lars Schwabe and Youwei Zheng

Chapter 6 Functional Brain Imaging Using Non-Invasive Non-Ionizing Methods: Towards Multimodal and Multiscale Imaging 115
Irene Karanasiou

Chapter 7 Diffusion Tensor Imaging: Structural Connectivity Insights, Limitations and Future Directions 137
Linda J. Lanyon

Chapter 8 A Triangulation-Based MRI-Guided Method for TMS Coil Positioning 163
Jamila Andoh and Jean-Luc Martinot

Chapter 9 Biocytin-Based Contrast Agents for Molecular Imaging: An Approach to Developing New In Vivo Neuroanatomical Tracers for MRI 181
Anurag Mishra, Kirti Dhingra, Ritu Mishra, Almut Schüz, Jörn Engelmann, Michael Beyerlein, Santiago Canals and Nikos K. Logothetis

Chapter 10 The Use of 31-Phosphorus Magnetic Resonance Spectroscopy to Study Brain Cell Membrane Motion-Restricted Phospholipids 205
Basant K. Puri and Ian H. Treasaden

Chapter 11 Pediatric Cranial Ultrasound: Techniques, Variants and Pitfalls 217
Kristin Fickenscher, Zachary Bailey, Megan Saettele, Amy Dahl and Lisa Lowe

Chapter 12 Impact of White Matter Damage After Stroke 233
Robert Lindenberg and Rüdiger J. Seitz

Chapter 13 Tissue Fate Prediction from Regional Imaging Features in Acute Ischemic Stroke 245
Fabien Scalzo, Xiao Hu and David Liebeskind

Chapter 14 MRI Assessment of Post-Ischemic Neuroinflammation in Stroke: Experimental and Clinical Studies 261
Fabien Chauveau, Marilena Marinescu, Cho Tae-Hee, Marlène Wiart, Yves Berthezène and Norbert Nighoghossian

Chapter 15 Intracerebral Hemorrhage: Influence of Topography of Bleeding on Clinical Spectrum and Early Outcome 277
Adrià Arboix and Elisenda Grivé

Chapter 16 Genetic Risk Factors of Imaging Measures Associated with Late-Onset Alzheimer’s Disease 293
Christiane Reitz

Chapter 17 Neuroimaging Findings in Dementia with Lewy Body: A Review 313
Francesca Baglio, Maria Giulia Preti and Elisabetta Farina

Chapter 18 Endoscopic Intracranial Imaging 339
Oscar H. Jimenez-Vazquez .

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Published by: Unknown - Tuesday, February 19, 2013


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