Open Access Medical Books

TEXTBOOK : NOVEL GENE THERAPY APPROACHES

GENE THERAPY

Edited by Ming Wei and David Good .

404 pages . 

Since the original discovery of the genetic code researchers and clinicians have hoped for the day when this knowledge can be used in the treatment of disease. Gene therapy is one of the technologies that have advanced in leaps and bounds though it is yet to fully realise its potential. 
However, it is believed that, in the foreseeable future, gene therapy will provide a potential “cure” for a number of diseases. Researchers have now shown that gene therapeutic approaches are generally more efficient than conventional therapies due to their specificity resulting in fewer side effects. Already, the approach has been utilised in various clinical trials for the treatment of genetic diseases as well as various cancers.
The aim of this book is to provide up-to-date reviews of the rapidly growing field of gene therapy. Contributions cover a large range of topics including methods and barriers of gene delivery, identification of targets, and a number of articles on cancer gene therapies. If more people become aware of the true nature and high potential of gene therapy, perhaps we can achieve the full benefit of such an innovative approach for the treatment of a range of diseases, including cancers.

Dr. Ming Wei
Griffith University, Australia

Dr. David Good
Australian Catholic University, Australia

CONTENTS :

Section 1 of the textbook : Approched to Gene Therapy .


Chapter 1 Targeted Gene Delivery: Importance of 
Administration Routes 3
Shintaro Fumoto, Shigeru Kawakami, Mitsuru Hashida and Koyo Nishida

Chapter 2 Electrically Mediated Gene Delivery : Basic and Translational 
Concepts 33
J. Teissié

Chapter 3 Solid Lipid Nanoparticles: Tuneable Anti-Cancer Gene/Drug Delivery Systems 53
Tranum Kaur and Roderick Slavcev

Chapter 4 Extracellular and Intracellular Barriers to Non-Viral Gene 
Transfer 75
Lynn F. Gottfried and David A. Dean


Section 2 of the textbook : Gene Therpay Using Viral Vectors .


Chapter 5 Viral Vectors for Vaccine Development 91
Qiana L. Matthews, Linlin Gu, Alexandre Krendelchtchikov and Zan C. Li

Chapter 6 Development of Muscle-Directed Systemic Cancer 
Gene Therapy 119
Koichi Miyake and Takashi Shimada

Chapter 7 Replicating Retroviral Vectors for Gene Therapy of 
Solid Tumors 129
Matthias Renner and Juraj Hlavaty

Chapter 8 A Novel Therapy for Melanoma and Prostate Cancer Using a 
Non-Replicating Sendai Virus Particle (HVJ-E) 157
Toshihiro Nakajima, Toshimitsu Itai, Hiroshi Wada, Toshie Yamauchi, Eiji Kiyohara and Yasufumi Kaneda

Chapter 9 Sendai Virus-Based Oncolytic Gene Therapy 183
Yosuke Morodomi, Makoto Inoue, Mamoru Hasegawa, Tatsuro Okamoto, Yoshihiko Maehara and Yoshikazu Yonemitsu

Section 3 of the textbook : Gene Therapy for Cancer .


Chapter 10 Challenges in Advancing the Field of Cancer Gene Therapy: An 
Overview of the Multi-Functional Nanocarriers 197
Azam Bolhassani and Tayebeh Saleh

Chapter 11 Cancer Gene Therapy: Targeted Genomedicines 261
Yadollah Omidi, Jaleh Barar and George Coukos

Chapter 12 Identification and Validation of Targets for Cancer Immunotherapy: From the Bench-to-Bedside 297
Ghazala Khan, Suzanne E. Brooks, Frances Denniss, Dagmar Sigurdardottir and Barbara-ann Guinn

Chapter 13 Targeting Intercellular Communication in Cancer 
Gene Therapy 327
Mohamed Amessou and Mustapha Kandouz

Chapter 14 Cancer Gene Therapy with Small Oligonucleotides 353
Onur Sakiragaoglu, David Good and Ming Q. Wei

Chapter 15 Poly(amino ester)s-Based Polymeric Gene Carriers in Cancer 
Gene Therapy 375
You-Kyoung Kim, Can Zhang, Chong-Su Cho, Myung-Haing Cho and Hu-Lin Jiang .


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Published by: younes younes - Sunday, February 17, 2013

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