Open Access Medical Books


Edited by John C. Morrison .
368 pages . 

Clinicians have struggled with the ravages of preterm birth for decades, even centuries, but we have solved many issues through our scientific strengths and there remains considerable hope of reducing the number of preterm births in the future.
While there are a multitude studies and books regarding preterm birth, both in the obstetric and the neonatal/pediatric literature, what is missing is the integration of data, from obstetrics through neonatal course, into pediatrics as the neonate transverses childhood. Certainly, pediatricians might wonder why obstetricians cannot keep the baby in utero longer, while obstetricians are rarely apprised of the continued progress of the baby once it is delivered.
Obstetricians do not actually know what goes on after the delivery any more than many pediatricians know about what happened during pregnancy, as well as labor, and delivery. This dialogue between specialties is crucial in the battle against preterm birth. While obstetrician looks for causes of preterm birth and strategies for preventing it, the neonatologist searches for treatments for the complications of preterm birth while the pediatrician seeks therapy for long-term morbidity of preterm birth on each organ system of the child. Clearly there needs to be more linkages between the specialties that are divided by birth.
This is especially true when confronted with preterm birth because it is certainly problematic for the obstetrician, the neonatologist, and the pediatrician in addition to the hospital, family and society in general.
The ultimate goal of this needed dialogue between specialties is to offset the effects or after-effects of preterm birth. In spite of medical advances, preterm birth is still all too common, and it’s ramifications are staggering. Babies that are born preterm, especially before 32 weeks gestation, are associated with the majority of neonatal morbidity and mortality. Preterm delivery before 37 weeks is all too common (i.e., 8-10% of births in the United States). The reasons for early delivery are varied. For example, fetal disease, such as severe growth restriction, oligohydramnios, or abnormal fetal health assessment tests, may dictate that the infant should be delivered even when it is extremely preterm. Also, maternal factors such as diabetes, preeclampsia, cardiopulmonary disorders, trauma and others may also require early delivery.

Similarly, obstetric complications such as preterm labor, preterm premature rupture of the membranes (usually with preterm labor), as well as cervical insufficiency among others, all may lead to birth before 37 weeks. Finally, preterm births may result from iatrogenic causes. Many times, late preterm births (34-37 weeks), occur when the physician deems the baby is near enough to term that attempting preventive treatment should not be undertaken or when the patient refuses treatment (i.e., tocolytics) ....

John C. Morrison
University of Mississippi Medical Center,
Jackson, MS,


Chapter 1 Assisted Reproduction and Preterm Birth 1
Offer Erez, Ruth Beer-Weisel, Tal Rafaeli-Yehudai, Idit Erez-Weiss and Moshe Mazor

Chapter 2 Environmental Exposures, Genetic Susceptibility and Preterm Birth 47
Regina Grazuleviciene, Jone Vencloviene, Asta Danileviciute, Audrius Dedele and Gediminas Balcius

Chapter 3 Clinical Risk Factors for Preterm Birth 73
Ifeoma Offiah, Keelin O’Donoghue and Louise Kenny

Chapter 4 Psychobiological Stress and Preterm Birth 95
Curt A. Sandman, Elysia P. Davis and Laura M. Glynn

Chapter 5 Oxidative Stress and Antioxidants: Preterm Birth and Preterm Infants 125
Robert A. Knuppel, Mohamed I. Hassan, James J. McDermott, J. Martin Tucker and John C. Morrison

Chapter 6 Weakening and Rupture of Human Fetal Membranes – Biochemistry and Biomechanics 151
N. Rangaswamy, D. Kumar, R.M. Moore, B.M. Mercer, J.M. Mansour, R. Redline and J.J. Moore

Chapter 7 The Effect of Inflammation on Preterm Birth 183
Grazzia Rey, Silvana Pereyra, Tatiana Velazquez, Daniel Grasso, Justo Alonso, Bernardo Bertoni and Rossana Sapiro

Chapter 8 Uterine Contraction Monitoring, Maintenance Tocolysis, and Preterm Birth 201
John C. Morrison, John P. Elliott and Stephen Jones

Chapter 9 Progestins and Preterm Birth 213
Helen Y. How and Baha M. Sibai

Chapter 10 Management of Abnormal Vaginal Flora as a Risk Factor for Preterm Birth 231
Gilbert G.G. Donders and Gert Bellen

Chapter 11 Strategies in the Prevention of Preterm Births During and Before Pregnancy 245
Wolf Kirschner and Klaus Friese

Chapter 12 Preterm Birth of Extremely Low Birth Weight Infants 263
Jonathan Muraskas, Lisa DeGregoris, Colleen Rusciolelli and Christine Sajous

Chapter 13 The Protective Role of Erythropoietin in the Developing Brain 275
Marco Sifringer, Angela M. Kaindl, Stefanie Endesfelder, Clarissa von Haefen, Ivo Bendix and Ursula Felderhoff-Mueser

Chapter 14 Preterm Birth and Long-Term Pulmonary Function 301
Indra Narang and Amal Al-Naimi

Chapter 15 Cardiovascular Consequences of Preterm Birth in the First Year of Life 319
Karinna Fyfe, Stephanie R. Yiallourou and Rosemary S.C. Horne

Chapter 16 The Effect of Preterm Birth on Kidney Development and Kidney Function over Time 341
M.G. Keijzer-Veen and A.J. van der Heijden .

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Published by: Unknown - Friday, February 8, 2013


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