Open Access Medical Books



Edited by Lester M. Davids .

384 pages .
Open Access . 

The book Recent Advances in the Biology, Therapy and Management of Melanoma brings the latest, up-to-date information regarding the biological mechanisms underlying melanoma epidemiology, molecular mechanisms and the therapeutic options that are employed in combating this dreaded disease. The first section covers the genetics of melanoma development with associated risk factors. Understanding the underlying molecular mechanisms of melanomagenesis, the biomarkers, and the proteins that contribute to melanoma, all lead to illuminating potential targets in the fight against this disease. This section is comprehensively reviewed and is essential to be interweaved and translated with the final section which culminates in current treatment options and clinically relevant regimes. The novelty of new treatment options are further highlighted in this section.
This book is intended to be a reference book for both the scientific and clinical communities.
It is not often easy to interweave these two disciplines but this book brings both of these together in an easy, readable way. The fact that there is so much ongoing scientific and clinical research in the field of melanoma is an indicator of the importance and relevance attached to understanding the human melanocyte and the factors that cause it to go awry. This fundamental scientific understanding has to then be translated to the clinic in order for us to make significant strides in eradicating this dreaded disease.
It is hoped that scientists, clinicians, students and residents find this book useful in their studies on melanoma and that it not only expands their perspectives and views on the field, but challenges them to forge ahead towards discovering the ultimate cure.

Lester M. Davids
Redox Laboratory, Department of Human Biology,
 Faculty of Health Sciences
University of Cape Town, South Africa


Section 1 of the textbook : Melanoma Epidemiology .

  1 Melanoma — Epidemiology, Genetics and Risk Factors 3 
John A. D’Orazio, Stuart Jarrett, Amanda Marsch, James Lagrew and Laura Cleary

Section 2 of the textbook : Molecular Mechanisms of Melanoma.

  2 Aberrant Death Pathways in Melanoma 39 
Nicholas D. Panayi, Erin E. Mendoza, Elliot S. Breshears and Randy Burd

  3 Interaction Between the Immune System and Melanoma 53 
Norma E. Herrera-Gonzalez

  4 MITF: A Critical Transcription Factor in Melanoma Transcriptional Regulatory Network 71 Jiri Vachtenheim and Lubica Ondrušová

  5 The Role of Oxidative Stress in Melanoma Development, Progression and Treatment 83 Fabiana Henriques Machado de Melo, Fernanda Molognoni and Miriam Galvonas Jasiulionis

  6 Expression of Matrix Metalloproteinases and Theirs Tissue 
Inhibitors in Fibroblast Cultures and Colo-829 and SH-4 Melanoma Cultures After Photodynamic Therapy 111 Aleksandra Zielińska, Małgorzata Latocha, Magdalena Jurzak and Dariusz Kuśmierz

  7 MMP-2 and MMP-9 Expression in Canine Cutaneous 
Melanocytic Tumours: Evidence of a Relationship with Tumoural Malignancy 133 Isabel Pires, Joana Gomes, Justina Prada, Dinora Pereira and Felisbina L. Queiroga

  8 Glutamate Signaling in Human Cancers 163 
Brian A. Wall, Seung-Shick Shin and Suzie Chen

Section 3 of the textbook : Melanoma Therapeutics .

  9 Current Therapies and New Pharmacologic Targets for 
Metastatic Melanoma 189 Claudriana Locatelli, Fabíola Branco Filippin-Monteiro and Tânia Beatriz Creczynski-Pasa

  10 Targeted Agents for the Treatment of Melanoma: An 
Overview 231 Hsiang-Wen Tseng, Wen-Tai Li⁺ and Jung-Feng Hsieh⁺

  11 Porphyrin and Phthalocyanine Photosensitizers as PDT Agents: 
A New Modality for the Treatment of Melanoma 253 Shawn Swavey and Matthew Tran

  12 Gene Therapy for Melanoma: Progress and Perspectives 283 
Bryan E. Strauss and Eugenia Costanzi-Strauss

  13 The Potential Importance of K Type Human Endogenous 
Retroviral Elements in Melanoma Biology 319 Jianli Dong, Gengming Huang, Rasheen Imtiaz and Fangling Xu

  14 Emerging GM3 Regulated Biomarkers in Malignant 
Melanoma 339 Pu Wang*, Peipei Guan*, Su Xu, Zhanyou Wang, Sadako Yamagata and Tatsuya Yamagata

  15 After Surgery: Follow-Up Guidelines of Melanoma 
Patients 361 Paolo Fava, Pietro Quaglino, Maria Grazia Bernengo and Paola Savoia . 

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Published by: Unknown - Sunday, February 17, 2013


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