Open Access Medical Books



Edited by Daniel Eberli .

602 pages . 
Open Access .

Tissue Engineering is the first medical therapy where engineered tissues could potentially become fully integrated within the patient, thus offering a permanent cure for many diseases not curable today. The National Science Foundation (NSF) defined Tissue Engineering in 1988 as the “application of the principles and methods of engineering and life sciences toward fundamental understanding of structure-function relationships in normal and pathological mammalian tissues and the development of biological substitutes to restore, maintain or improve tissue function (Shalak and Fox, 1988). Two decades later, Tissue Engineering/Regenerative Medicine is still a growing and exciting field of research applying knowledge of biology, physiology and cell culture techniques to offer new treatment options for patients in need of replacement tissues.
The two prerequisites for the successful engineering of an organ are suitable cells and a biomaterial or extra celluar matrix component. A large variety of cells has been proposed for the use in tissue engineering, including pluripotent embryonic stem cells (ESC) with all their ethical controversies, adult stem cells found in most tissues, and committed precursor cells. While the plasticity of ESC offers the potential to grow an entire organ from a single cell source, the clear differentiation of these cells remains challenging. Currently, adult cells seem to have certain advantages regarding rapid clinical translation. Most biomaterials used in Tissue Engineering are based on acellular matrices or polyglycolic acid. Both materials must provide tissue support until the cells produce their own extracellular matrix.
Ideally, they degrade thereafter without any toxic byproducts. Over the last years we started to understand the influence of the biomechanical environment allowing these cell-biomaterial composites to unfold their full functional potential.
However, many fundamental questions regarding cells and biomaterials remain unanswered.
This book will be of interest to anyone interested in the application of Tissue Engineering. It offers a wide range of topics, including the use of stem cells and adult stem cells, their applications and the development of a tailored biomaterial, highlighting the importance of cell-biomaterial interaction. It offers insights into a wide variety of cells and biomaterials, explaining the groundwork required to open the avenue to the next generation biotechnology, which is Tissue Engineering.
Finally, I would like to express my appreciation to all authors who have contributed to this book.

Daniel Eberli

University Zurich


Part 1 of the textbook :  Regenerative Medicine .

  1 Fundamental Technological Developments Required for 
Increased Availability of Tissue Engineering 3 Hideaki Kagami, Hideki Agata, Ryuji Kato, Fumiko Matsuoka and Arinobu Tojo

Part 2 of the textbook : Cells for Regenerative Medicine .

  2 Bone and Cartilage from Stem Cells: Growth Optimalization 
and Stabilization of Cell Phenotypes 23 Jan O Gordeladze, Janne E Reseland, Tommy A Karlsen, Rune B Jakobsen, Lars Engebretsen, Ståle P Lyngstadaas, Isabelle Duroux-Richard, Christian Jorgensen and Jan E Brinchmann

  3 Mesenchymal Stem Cell-Based Bone Engineering 
for Bone Regeneration 57 Mohamadreza Baghaban Eslaminejad and Faezeh Faghihi

  4 From Multipotent Cells to Fully Differentiated Connective 
Tissue Cells for Regenerative Medicine: Emerging Applications of Mesenchymal Stem Cells 83 Ali Mobasheri, Stephen M. Richardson, Judith A. Hoyland, Constanze Buhrmann and Mehdi Shakibaei

  5 Skeletal Regeneration by Mesenchymal Stem Cells: What Else?
107 José A. Andrades, Silvia Claros, Pedro Jiménez-Palomo, José Mª López‐Puertas, Plácido Zamora‐Navas, Enrique Guerado, Manuel Monleón, María C. Araque and José Becerra

  6 Production of Clinical Grade Mesenchymal 
Stromal Cells 145 Pytlík, Slanař, Stehlík and Matějková

  7 Adipose-Derived Stem Cells (ASCs) for 
Tissue Engineering 179 Mathias Tremp, Souzan Salemi, Rita Gobet, Tullio Sulser and Daniel Eberli

  8 In Vitro Culture Methods of Skin Cells for Optimal Skin 
Reconstruction by Tissue Engineering 195 Moulin VJ, Mayrand D, Laforce-Lavoie A, Larochelle S and Genest H

  9 Mesenchymal Stem Cells for Cell Therapy and Tissue 
Regeneration in Urology 209 Yingai Shi and Yuanyuan Zhang

  10 Glandular Stem Cells: 
A New Source for Myocardial Repair? 229 Norbert W. Guldner, Charli Kruse and Hans - H. Sievers

Part 3 of the textbook : Biomaterials for Regenerative Medicine .

   11 Preparation and Characterization Urea-Solubilized 
Sol-Gel Type I Collagen and Its Possible Use in Applications 245 Xin Xiong, Herwig Brunner and Robin Ghosh

  12 Direct Use of Resorbable Collagen-Based Beads 
for Cell Delivery in Tissue Engineering and Cell Therapy Applications 261 Veronica Glattauer, Wei-Bor Tsai, Jacinta F. White, Julie Nigro, Tracy A. Tebb, Jerome A. Werkmeister and John A.M. Ramshaw

  13 Collagen: Applications of a Natural Polymer 
in Regenerative Medicine 287 Umber Cheema, Michael Ananta and Vivek Mudera

  14 Tissue-Engineered Extracellular Matrices (ECMs) 
as Adjuvant Scaffolds for Endovascular Aneurysmal Repair (EVAR) 301 Anthony Callanan, Niall F. Davis, Michael T. Walsh and Tim M. McGloughlin

  15 Elastin Based Constructs 323 
Lisa Nivison-Smith and Anthony Weiss

  16 The Use of a Hydrogel Matrix as a Cellular Delivery Vehicle in Future Cell-Based Therapies: Biological and Non-Biological Considerations 341 Thomas I. Zarembinski, William P. Tew and Sarah K. Atzet

  17 Cockle Shell-Based Biocomposite Scaffold for Bone Tissue Engineering 365 Zuki Abu Bakar, Bahaa F. Hussein and Noordin Mohamed Mustapha

Part 4 of the textbook : Advanced Strategies .

  18 Bioactive Scaffolds for the Controlled Formation of 
Complex Skeletal Tissues 393 Sandra Hofmann and Marcos Garcia-Fuentes

  19 Angiogenesis and Vascularity for Tissue Engineering 
Applications 433 Remo A. Largo, Venkat M. Ramakrishnan, Martin Ehrbar, Algirdas Ziogas, Jan A. Plock and Daniel Eberli

  20 The Liver Vascular Bed for Hepatocytes Cell Therapy and
Tissue Engineering 449 Yaacov Baruch

  21 Nano- Coating with Titanium of Glutaraldehyde- Fixed Heart 
Valve Prostheses Enables a Reduced Immune Response and a Self-Seeding Within Circulation 463 Norbert W. Guldner, Hangörg Zimmermann and Hans- H. Sievers

  22 Formation of Stable Vascular Networks in 
Engineered Tissues 477 Bin Jiang and Eric M. Brey

  23 Tunable Stimuli-Responsive Polymers for Cell Sheet 
Engineering 503 Nithya Joseph, Anil Kumar P R and TV Kumary

  24 Gene-Silencing for Treatment of 
Cardiovascular Diseases 513 A. Nolte, M. Schneider, T. Walker and H. P. Wendel

  25 Hydrodynamic 3D Culture for Bone 
Tissue Engineering 527 Dajiang Du, Takashi Ushida and Katsuko Furukawa

Part 5 of the textbook : Cell - Biomaterial Interaction .

  26 The Fibrotic Response to Implanted Biomaterials: 
Implications for Tissue Engineering 551 Barbara Rolfe, Jane Mooney, Bing Zhang, Sani Jahnke, Sarah-Jane Le, Yu-Qian Chau, Qiping Huang, Hao Wang, Gordon Campbell and Julie Campbell

  27 Cell Responses to Surface and Architecture of Tissue 
Engineering Scaffolds 569 Hsin-I Chang and Yiwei Wang .

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Published by: Unknown - Thursday, February 7, 2013


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