Open Access Medical Books

TEXTBOOK : RESEARCH DIRECTIONS IN TUMOR ANGIOGENESIS

TUMOR ANGIOGENESIS
Edited by Jianyuan Chai .
300 pages .

As a process of extension of the vascular network within human body, angiogenesis plays a 
fundamental role to support cell survival, because all cells need oxygen and nutrients to operate 
and blood circulation is the only way to provide them. In human adults, angiogenesis mainly 
takes place in two conditions, wound healing and tumor progression. During wound healing, 
angiogenesis supports new tissue growth to repair the wound; therefore, it is beneficial to the 
body and should be promoted. In tumor progression, on the other hand, angiogenesis is hijacked 
to serve the mutated cells for their multiplication and therefore, it should be inhibited.
This book focuses on the second situation – angiogenesis in tumor progression. However, since 
the molecular and cellular interactions under both conditions are essentially identical, the content 
of the book is suitable for all the readers who are interested in angiogenesis....

Jianyuan Chai, Ph.D.
Laboratory of GI Injury and Cancer
VA Long Beach Healthcare System and
University of California
Long Beach, California
USA

CONTENTS OF THE TEXTBOOK :


Chapter 1 Transcriptional Modulation of Tumour Induced 
Angiogenesis 1
Jeroen Overman and Mathias François

Chapter 2 Roles of SRF in Endothelial Cells During Hypoxia 29
Jianyuan Chai

Chapter 3 Manipulating Redox Signaling to Block Tumor 
Angiogenesis 47
Vera Mugoni and Massimo Mattia Santoro

Chapter 4 Accessory Cells in Tumor Angiogenesis — Tumor-Associated 
Pericytes 73
Yoshinori Minami, Takaaki Sasaki, Jun-ichi Kawabe and Yoshinobu Ohsaki

Chapter 5 Endothelial and Accessory Cell Interactions in Neuroblastoma 
Tumor Microenvironment 89
Jill Gershan, Andrew Chan, Magdalena Chrzanowska-Wodnicka, Bryon Johnson, Qing Robert Miao and Ramani Ramchandran

Chapter 6 T-Cadherin Stimulates Melanoma Cell Proliferation and 
Mesenchymal Stromal Cell Recruitment, but Inhibits Angiogenesis in a Mouse Melanoma Model 143
K. A. Rubina, E. I. Yurlova, V. Yu. Sysoeva, E. V. Semina, N. I. Kalinina, A. A. Poliakov, I. N. Mikhaylova, N. V. Andronova and H. M. Treshalina

Chapter 7 The Use of Artemisinin Compounds as Angiogenesis Inhibitors 
to Treat Cancer 175
Qigui Li, Peter Weina and Mark Hickman

Chapter 8 3-D Microvascular Tissue Constructs for Exploring Concurrent 
Temporal and Spatial Regulation of Postnatal Neovasculogenesis 261
Mani T. Valarmathi, Stefanie V. Biechler and John W. Fuseler .


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Published by: younes younes - Wednesday, February 6, 2013

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