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TEXTBOOK : REVIEWS ON SELECTED TOPICS OF TELOMERE BIOLOGY

TELOMERE

Edited by Bibo Li .

304 pages . 

The sequence of Tetrahymena telomere DNA was the first to be determined among all eukaryotes by Elizabeth (Liz) Blackburn and Joseph Gall in 1978, and the yeast telomere was first cloned by Jack Szostak and Liz Blackburn in 1982. A few years later, the telomerase activity was first identified in Tetrahymena by Carol Greider and Liz Blackburn in 1985. These discoveries are miles stones marking the beginning of molecular era of telomere biology. Since then a tremendous amount of studies have demonstrated that telomeres are essential for genome stability and integrity, and maintaining telomere length homeostasis is the prerequisite for normal chromosome end protection. The significance of telomere study is highlighted by the 2009 Nobel prize in Physiology or Medicine awarded to Liz Blackburn, Carol Greider, and Jack Szostak for their discovery of how chromosomes are protected by telomeres and the enzyme telomerase. Although the award is no doubt one of the most exciting events in the history of telomere biology, by no means it signals that we have reached the peak of telomere research. The golden era of telomere studies continues, and the telomere field is still moving at a strong and fast pace. New findings about telomere functions and the underlying mechanisms are revealed every day. Particularly, there are more
and more studies linking telomere dysfunction to a number of human diseases. Not only are telomere functions implicated in aging and age-related diseases, they are also important for microbial pathogen virulence. In addition, as our knowledge about telomere components expands, new non-telomeric roles of telomere proteins are revealed.
This book includes several current reviews on a few selected topics of telomere biology, including telomere length maintenance and its regulation, telomere and human diseases, novel extra-telomeric functions of telomere proteins, and finally a touch on telomere sequence evolution. We hope reviewing available data would help us to focus better on future research directions and make faster progresses in understanding various aspects of telomere functions.

Bibo Li
Center for Gene Regulation in Health & Disease Dept. of Biological,
Geo. & Env. Sciences, Cleveland State University,
USA

CONTENTS :


Section 1 of the textbook : Telomere Length and Its Regulation .


Chapter 1 Telomere Length and Aging 3
Radhika Muzumdar and Gil Atzmon

Chapter 2 Control of Telomere Length in Drosophila 31
Sergey Shpiz and Alla Kalmykova

Chapter 3 The Regulation of Telomerase 
by Alternative Splicing of TERT 57
Jiří Nehyba, Radmila Hrdličková and Henry R. Bose, Jr.

Section 2 of the textbook : Telomeres and Human Diseases .


Chapter 4 Telomere and Telomerase in Cancer: Recent Progress 95
Güvem Gümüş-Akay and Ajlan Tükün

Chapter 5 Inhibiting Telomerase Activity and Inducing Apoptosis 
in Cancer Cells by Several Natural Food Compounds 123
Didem Turgut Cosan and Ahu Soyocak

Chapter 6 Telomeres and Reproductive Aging 149
Sena Aydos

Chapter 7 Telomeres and Lifestyle Choices 175
Cigir Biray Avci

Chapter 8 Telomere as an Important Player in Regulation 
of Microbial Pathogen Virulence 195
Bibo Li

Section 3 of the textbook : Noncanonical Functions of the Telomere .


Chapter 9 Extra-Telomeric Roles of Telomeric Proteins 243
Arkasubhra Ghosh and Vinay Tergaonkar

Section 4 of the textbook : Telomere DNA and Its Evolution .


Chapter 10 Genomic Distribution of Telomeric DNA Sequences – 
What Do We Learn from Fish About Telomere Evolution? 271
Konrad Ocalewicz .


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