Open Access Medical Books


Edited by Shigehito Yamada and Tetsuya Takakuwa .
192 pages . 

Human embryology is now rapidly moving to a new phase due to recent innovation 
and advances of life science including ES and iPS technology. This new era also 
directs a difficult challenge for scientists in terms of technological and ethical issues 
for future human embryology. However, human embryology is difficult to research 
due to ethics involved in the collection of human materials. This book traces the 
early history and provides knowledge on demonstration of principles from ancient 
to the most recent embryo studies amidst the unresolved scientific and ethical 
In the first introductory section, various human embryo collections are summarized 
with four well-known ones: The Carnegie, the Blechschmidt, the Hinrichsen and the 
Kyoto collections. Although remarkable progress has been achieved in studying 
each collection, there are very few reviews available that summarize the past and the 
present of the collections. Therefore, this book discusses in vivid detail how human 
embryology has changed since ancient discoveries to most recent research done.
The next section covers “implantation” as a theme. This section reviews the outline of 
ethical and technical issues related to implantation. In this context, four chapters are 
included and discussed. The ethical issue and its adaptation depend on the country, 
region, race and religions. Although this section does not cover all the directions, the 
chapters are dedicated to all international persons to be free and open discussion for 
better understanding. We are glad this book will trigger deeper discussions of this 
The third section deals with “organogenesis”. The techniques and tools for studying 
morphogenetic changes and fundamental understanding of organogenesis are 
discussed. In organogenesis, miscarriages often occur and genetic analyses are 
required for elucidation of the cause and one such paper reviewing cytogenetic aspects 
of miscarriages is adopted.
In dealing with the special subject of this book, we wish to acknowledge the courtesy 
of the publishers and everyone involved in Japan and overseas for their valid 
contribution. We hope this book will help the readers to understand human embryo 
development better.

Dr. Shigehito Yamada
M.D., Ph.D., Congenital Anomaly Research Center,
Kyoto University, Graduate School of Medicine, Kyoto,

Professor Tetsuya Takakuwa,
M.D., Ph.D., Human Health Science,
Kyoto University Graduate School of Medicine, Kyoto,

Chapter 1 Introduction – Developmental Overview of the Human Embryo 3
Shigehito Yamada and Tetsuya Takakuwa

Chapter 2 Presenting Human Embryology in an 
International Open-Access Reference Centre (HERC) 21
Beate Brand-Saberi, Edgar Wingender, Otto Rienhoff and Christoph Viebahn

Part 2 of the textbook : Implantation .

Chapter 3 Optimal Environment for the 
Implantation of Human Embryo 37
Paweł Kuć

Chapter 4 Immune Regulation of Human Embryo 
Implantation by Circulating Blood Cells 61
Hiroshi Fujiwara, Yukiyasu Sato, Atsushi Ideta, Yoshito Aoyagi, Yoshihiko Araki and Kazuhiko Imakawa

Chapter 5 The Future of Human Embryo 
Culture Media – Or Have We Reached the Ceiling? 73
Deirdre Zander-Fox and Michelle Lane

Chapter 6 Benzo[a]pyrene and Human Embryo 99
Shi Jiao, Bingci Liu and Meng Ye

Part 3 of the textbook : Organogenesis and Genetics .

Chapter 7 Developmental Anatomy of the Human Embryo – 
3D-Imaging and Analytical Techniques 111
Shigehito Yamada, Takashi Nakashima, Ayumi Hirose, Akio Yoneyama, Tohoru Takeda and Tetsuya Takakuwa

Chapter 8 Cardiovascular Development in the First Trimester 127
Preeta Dhanantwari, Linda Leatherbury and Cecilia W. Lo

Chapter 9 Development, Differentiation and Derivatives of the Wolffian and Müllerian Ducts 143
Monika Jacob, Faisal Yusuf and Heinz Jürgen Jacob

Chapter 10 Cytogenetic Analysis of Spontaneous Miscarriage 167
Nobuaki Ozawa .

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Published by: Unknown - Friday, February 8, 2013


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