Open Access Medical Books



Edited by Laura Sterian Ward .

330 pages . 
Open Access .

Thyroid and parathyroid diseases are among the most frequent conditions we have to deal with in a clinical setting. Both nodular and autoimmune diseases affecting these glands have increased remarkably over the past decades. The widespread use of crosssectional  imaging and the introduction of neck ultrasonography have led to a thyroid  nodule epidemics and the diagnostic of neck lesions in half of the population.
Consequently, many patients with microscopic papillary thyroid cancers of uncertain  clinical significance are submitted to surgeries that may, perhaps, be unnecessary.
Differentiated thyroid cancer is the fastest‐growing cancer in women; it increased 2.4%  per year during 1980 to 1997 and 6.5% per year during 1997 to 2006 in the USA according  to the National Cancer Instituteʹs Surveillance Epidemiology and End Results (SEER).
On the other hand, the refinement of new approaches for surveillance of patients with an  established diagnosis of thyroid cancer is leading to the observation that many patients,  previously thought to be cured, have evidence of minimal residual disease, a condition  with which we still do not know how to manage properly.
Evaluating the Thyroid Gland and its Diseases section includes useful information into the anatomy and functions of the thyroid gland; the thyroid neoplasm and its  most challenging type, the papillary thyroid microcarcinoma; the use and technical  peculiarities of thyroglobulin dosages and fine aspiration citology. In addition,  important articles approach basic aspects of thyroid carcinogenesis, namely growth  factors, angiogenesis, and the importance of estrogen signaling on thyrocyte  proliferation.
The increase in autoimmune thyroid diseases has been no less remarkable than that of  thyroid nodules, but it is more difficult to document. However, there are evidences  indicating that around 5‐10% of the population suffers from a thyroid dysfunction,  mostly autoimmune hypothyroidism. A beautiful article from Dr Cury explains to the  reader how our immune system copes with the modifications associated to  autoimmune thyroid diseases.
Thyroid disease can affect your mood, causing either anxiety or depression, and a  second section of the book, Psychiatric disturbances associated to thyroid diseases, groups three very interesting articles approaching the psychiatric disturbances and the psychosocial aspects associated to thyroid diseases.
Finally, the third section, Treatment of Thyroid and Parathyroid Diseases, is designed mostly to the young practitioner. In fact, the field of thyroid and parathyroid surgery as well as thyroid diseases treatment modalities have undergone rapid change in the past few years with the advent of new techniques and the appearing of new basic and clinical evidences. Also, we need to understand how hormone analogs may affect our glands and a hole chapter is devoted to this subject.
The burden of thyroid and parathyroid diseases continue to increase and a better knowledge of these pathologies molecular, epidemiological and clinical behavior is essential in order to better manage our patients.
Thyroid and Parathyroid diseases aims to provide meaningful information to the practitioner through the eyes of though leaders in the discipline who have contributed their time and expertise to this effort. It is not a comprehensive textbook but rater a carefully chosen collection of very important topics written and illustrated in a form that hopefully will please all, the clinicians, the surgeons, the pathologists, the radiologists and all the fans of the head and neck diseases.
Hope you enjoy it!

Laura Sterian Ward

Associate Professor of Medicine at the Faculty of Medical Sciences,
State University of Campinas,


Part 1 of the textbook : Evaluating the Thyroid Gland and Its Diseases 

 1 Introduction to Thyroid:Anatomy and Functions 3 Evren Bursuk

 2 The Thyroglobulin:A Technically Challenging Assay for a Marker of Choice During the Follow Up of Differentiated Thyroid Cancer 23 Anne Charrié

 3 Papillary Thyroid Microcarcinoma –Do Classical Staging Systems Need to Be Changed? 33 Carles Zafon

 4 Thyroid Neoplasm 45 Augusto Taccaliti, Gioia Palmonella, Francesca Silvetti and Marco Boscaro

 5 Thyroid Growth Factors 77 Aleksander Konturek and Marcin Barczynski

 6 Vascular Endothelial Growth Factor (VEGF)and Epidermal Growth Factor (EGF) in Papillary Thyroid Cancer 87 Aleksander Konturek and Marcin Barczynski

 7 Immune Profile and Signal Transductionof T-Cell Receptor in Autoimmune Thyroid Diseases 95 Adriano Namo Cury

 8 Estrogen Signaling and Thyrocyte Proliferation 109 Valeria Gabriela Antico Arciuch and Antonio Di Cristofano

 9 Suspicious Thyroid Fine Needle Aspiration Aspiration Biopsy:TSH as a Malignancy Marker? 125 Renata Boldrin de Araujo, Célia Regina Nogueira, Jose Vicente Tagliarini, Emanuel Celice Castilho, Mariângela de Alencar Marques, Yoshio Kiy, Lidia R. Carvalho and Gláucia M. F. S. Mazeto

Part 2 of the textbook : Treatment of Thyroid and Parathyroid Diseases 

 10 Minimally-Invasive Parathyroid Surgery 135  David Rosen, Joseph Sciarrino and Edmund A. Pribitkin

 11 Management of Primary Hyperparathyroidism:‘Past, Present and Future’ 147 Sanoop K. Zachariah

 12 Treatment Modalities in Thyroid Dysfunction 171 R. King and R.A. Ajjan

 13 New Technologies in Thyroid Surgery 189 Bahri Çakabay and Ali Çaparlar

 14 Management of Primary Hyperparathyroidism 203 Jessica Rose and Marlon A. Guerrero

 15 Synthetic and Plant Derived Thyroid Hormone Analogs 221 Suzana T. Cunha Lima, Travis L. Merrigan and Edson D. Rodrigues

Part 3 of the textbook : Psychiatric Disturbances Associated to Thyroid Diseases

 16 Thyroid and Parathyroid Diseasesand Psychiatric Disturbance 239  A. Lobo-Escolar, A. Campayo, C.H. Gómez-Biel and A. Lobo

 17 Depressive Disorders and Thyroid Function 259 A. Verónica Araya, Teresa Massardo, Jenny Fiedler, Luis Risco, Juan C. Quintana and Claudio Liberman

 18 Psychosocial Factors in Patients with Thyroid Disease 279 Petra Mandincová .

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Published by: younes younes - Saturday, February 2, 2013


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