Open Access Medical Books


Edited by Kotb Abdelmohsen .
214 pages .

Proteins are the driving force for all cellular processes. They regulate several cellular events through binding to different partners in the cell. They are capable of binding to other proteins, peptides, DNA, and also RNA. These interactions are essential in the regulation of cell fates and could be important in drugs development. For example RNA interacting proteins regulate gene expression through the binding to different mRNAs. These mRNAs could be involved in important cellular processes such as cell survival or apoptosis. This book contains review articles dealing with protein interactions with the above mentioned factors. The enclosed articles could be informative and stimulating for readers interested in protein binding partners and the consequences of such interactions.

Kotb Abdelmohsen, PhD
Laboratory of Molecular Biology and Immunology National Institute on Aging,
National Institutes of Health Biomedical Research Center


Chapter 1 Transferrin Binding Proteins as a Means to Obtain Iron in Parasitic Protozoa 1
Magda Reyes-López, Jesús Serrano-Luna, Carolina Piña-Vázquez and Mireya de la Garza

Chapter 2 The Potential Role of Binding Proteins in Human Parasitic Infections: An In-Depth Look at the Novel Family of Nematode-Specific Fatty Acid and Retinol Binding Proteins 35
Jennifer L. Bath and Amber E. Ferris

Chapter 3 Protein-Peptide Interactions Revolutionize Drug Development 49
Elif Ozkirimli Olmez and Berna Sariyar Akbulut

Chapter 4 More Than a Simple Lock and Key Mechanism: Unraveling the Intricacies of Sperm-Zona Pellucida Binding 73
Kate A. Redgrove, R. John Aitken and Brett Nixon

Chapter 5 Modulation of Gene Expression by RNA Binding Proteins: mRNA Stability and Translation 123
Kotb Abdelmohsen

Chapter 6 Cationic Peptide Interactions with Biological Macromolecules 139
Monde Ntwasa

Chapter 7 The Study of MASPs Knockout Mice 165
Minoru Takahashi, Daisuke Iwaki, Yuichi Endo and Teizo Fujita
Chapter 8 CELF1, a Multifunctional Regulator of Posttranscriptional Networks 181
Daniel Beisang, Paul R. Bohjanen and Irina A. Vlasova-St. Louis .

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