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TEXTBOOK : INNOVATIVE RHEUMATOLOGY

INNOVATIVE RHEUMATOLOGY
Edited by Hiroaki Matsuno .
316 pages . 

First of all, we are delighted to be able to provide the "Innovative Rheumatology" to 
everyone involved in the treatment and research of rheumatoid arthritis. In recent years, the 
treatment of Rheumatoid Arthritis has undergone tremendous changes due to methotrexate 
and biologics in large part. Until a decade ago, avoiding joint destruction in rheumatoid 
arthritis was not realistic for rheumatologist. However, prevention of joint deterioration is 
now possible, and the quality of life of patients with rheumatoid arthritis in long-term has 
been able to improve by advances in treatment. However, there are still many problems to 
be overcome before achieving the treatment of rheumatoid arthritis. All of review articles 
presented on this book are explaining treatment, basic research, and patient care of 
rheumatoid arthritis with innovative perspective and ideas. I hope that the ideas that have 
been described in these articles help the reader to resolve the outstanding issues in 
rheumatoid arthritis. Finally, the editor would like to thank the wonderful authors for their 
contribution to this book. Furthermore, I would like to thank Mr. Danijela Duric and Ms.
Silvia Valsa of InTech's for their unfailing help.

Hiroaki Matsuno
Director,
Matsuno Clinic for Rheumatic Diseases,
Toyama, Japan

CONTENTS :

Section 1 of the textbook :  Basic Science .


Chapter 1 Sphingosine-1-Phosphate and Rheumatoid Arthritis: 
Pathological Implications and Potential Therapeutic Targets 3
Zhiyi Zhang and Chenqi Zhao

Chapter 2 New Therapeutic Targets for the Control of Inflammatory 
Arthritis: A Pivotal Role for Endothelins 29
Maria das Graças Muller de Oliveira Henriques

Chapter 3 The Role of Micro-RNAs in Rheumatic Diseases: 
An Update 51
Giovanni Ciancio, Manuela Ferracin, Massimo Negrini and Marcello Govoni

Chapter 4 Catecholestrogens in Rheumatoid Arthritis (RA): 
Hidden Role 71
Wahid Ali Khan and Mohd. Wajid Ali Khan

Section 2 of the textbook : Clinical Science .


Chapter 5 Treatment of Rheumatoid Arthritis with Biological Agents 95
Hiroaki Matsuno

Chapter 6 Perioperative Surgical Site Infections and Complications in 
Elective Orthopedic Surgery in Patients with Rheumatoid Arthritis Treated with Anti-Tumor Necrosis Factor-Alpha Agents − Discontinue or Not, Clinical Dilemma 109
Koichiro Komiya and Nobuki Terada

Chapter 7 Extraskeletal Manifestations in Rheumatoid Arthritis - 
Clinical Cases 131
Katarzyna Romanowska-Próchnicka, Przemysław Rzodkiewicz, Marzena Olesińska, Dariusz Szukiewicz and Sławomir Maśliński

Chapter 8 Small Molecule DMARD Therapy and Its Position in RA 
Treatment 165
Hiroaki Matsuno

Chapter 9 Gas-Therapy in Rheumatoid Arthritis Treatment: When West 
Meets East – Actual Medical Concepts with Ancient World Ideas 189
Michal Gajewski, Slawomir Maslinski, Przemyslaw Rzodkiewicz and Elzbieta Wojtecka-Lukasik

Chapter 10 Laryngeal Manifestations of Rheumatoid Arthritis 215
Stevan Stojanović and Branislav Belić

Chapter 11 Andrographolide a New Potential Drug for the Long Term 
Treatment of Rheumatoid Arthritis Disease 247
María A. Hidalgo, Juan L. Hancke, Juan C. Bertoglio and Rafael A. Burgos

Chapter 12 Efficacy of Nandrolone Decanoate in Treating Rheumatoid 
Cachexia in Male Rheumatoid Arthritis Patients 271
Andrew B. Lemmey, Srinivasa Rao Elamanchi, Samuele M. Marcora, Francesco Casanova and Peter J. Maddison

Chapter 13 Role of Cysteine Cathepsins in Joint Inflammation and 
Destruction in Human Rheumatoid Arthritis and Associated Animal Models 287
Uta Schurigt .


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