Open Access Medical Books



Edited by Mariko Tomita .

148 pages . 

T-cell leukemia is relativelyrare malignancyof thymocytes. There are around 20 entities and variants of this disease. Each of them has different characteristics, including pathogenesis, epidemiology, diagnosis, therapeutic approaches, and prognosis. Although T-cell leukemia is relatively rare malignancy, many types of T-cell leukemias still havea very poor prognosisdue to rapid progression. The refore, development of novel therapeutic and preventive strategiesis necessary to improve prognosis. The purpose of this book entitled “T-Cell Leukemia - Characteristics, Treatment and Prevention”is to provide a comprehensive overview of the disease from the basics of pathogenesis, epidemiology, morphology, and immunological features. This book also highlights the most recent achievements from basic and clinical research including molecular mechanisms and novel therapies of T-cell leukemia.
The present book features contributions from international authors in various clinical and research fields of T-cell leukemia.The first chapter, “Molecular Pathogenesis of T-Cell leukemia” by Drs. Michael Litt, Bhavita Patel, Ying Li Yi Qiu and Suming Huang, provides an overview of molecular changesassociated withpathogenesisof T-cell acute leukemia (TALL).
Specifically, chromosomal translocations which involve rearrangement of T-cell receptors and gene mutations which deregulate importantsignaling pathways involved in T-cell leukemogenesisare described. The second chapter, “Monoclonal Antibody Therapy of T-cell Leukemia and Lymphoma”writtenby Drs. TahirLatif, and John C. Morris, focuses on the current status of monoclonal antibody therapy of T-cell leukemia and lymphoma.A number of antibodies, including anti-CD2, anti-CD3, anti-CD4, anti-CD5, anti-CD25, anti-CD30, anti- CD52, anti-CD122, and anti-CCR4, which are currently studied for antibody therapy of Tcell
leukemia and lymphoma are summarized.Chapter 3, “T- and NK/T-Cell Leukemia in East Asia”was written by Drs. Tsung-Hsien Lin, Yen-Chuan Hsieh, Sheng-Tsung Chang,and Shih-Sung Chuang.The countries in East Asia have higher relative frequencies of these types of leukemias and there are some differences in the clinical and pathological characteristics between Western and Asian countries.This chapter gives usan overview of clinico-pathological analysis of various types of T- and NK/T-cell leukemias in the East Asia.
The next four chapters cover the topics of human T-cell leukemia virus type 1(HTLV-1) and adult T-cell leukemia/lymphoma (ATLL).Chapter 4, “Htlv-1-tax--all-roads-lead-to-transformation” by Drs. Kendle Pryor and Susan J. Marriott, describes contribution of HTLV-1 viral protein Tax to transformation of HTLV-1 infected cells. In this chapter, cellular transformation by Tax both in tissue culture and transgenic mouse models are summarized.The molecular mechanisms of Tax mediated transformation isalso described from several aspects, such as transcription factors, DNA repair pathways, and cell cycle regulation.Chapter 5,“Glycan Profiling Analysis of Adult T-cell Leukemia (ATL) Cells with the High Resolution Lectin Microarrays”is written by Drs. HidekatsuIha and Masao Yamada. Glycans have been considered biomarkers of cancer. In this chapter, the evidences that glycan profiles are useful biomarker for diagnosis and prognosis ofATLL are discussed. Chapter 6, “Prevention of Human T-Cell Lymphotropic Virus Infection and Adult T-Cell Leukemia”, is written by Drs. Makoto Yoshimitsu, Tomohiro Kozako, NaomichiArima.Although many efforts to prevent infection of HTLV-1 have been made in many countries, about 20 million people are infected with HTLV-1 and ATLL is still developed among carriers. Understanding how to prevent HTLV-1 infection and treatment related diseases is still big issue in the world health. This chapter provides the overview of prevention and current treatment for ATLL not only from clinical but also from research aspects. The last chapter, Chapter 7, “The Roles of AMP-Activated Protein Kinase-Related Kinase 5 as a Novel Therapeutic Target of Human T-cell Leukaemia Virus Type 1-Infected T-Cells” by Dr. Mariko Tomita was focused on ARK5, a fifth member of the AMP-activated protein kinases(AMPK) catalytic subunit family and analyzed its role on the growth of HTLV-1-infected T-cells.The novel findings that ARK5 is a novel target of NF-κB andaccelerates the growth of HTLV-1-infected T-cells during glucose starvationare summarized.
As an editor of this book,I would like to acknowledge all of the authors for their significant dedication and excellent works. I also thank Ms. ViktorijaZgela and entireInTech editorial team for helping me to publish this book. This book addresses key issues of characteristics, treatment and prevention of T-cell leukemia. I hope thatthis book will helpto developbasic and clinical approaches for treatment and prevention of T-cell leukemia.

Mariko Tomita

University of the Ryukyus


Chapter 1 Molecular Morphogenesis of T-Cell Acute Leukemia 1 
Michael Litt, Bhavita Patel, Ying Li, Yi Qiu and Suming Huang

Chapter 2 Monoclonal Antibody Therapy of T-Cell Leukemia and 
Lymphoma 33 Tahir Latif and John C. Morris

Chapter 3 T- and NK/T-Cell Leukemia in East Asia 53 
Tsung-Hsien Lin, Yen-Chuan Hsieh, Sheng-Tsung Chang and Shih- Sung Chuang

Chapter 4 Pleiotropic Functions of HTLV-1 Tax Contribute to Cellular 
Transformation 67 Kendle Pryor and Susan J. Marriott

Chapter 5 Glycan Profiling of Adult T-Cell Leukemia (ATL) Cells with the 
High Resolution Lectin Microarrays 89 Hidekatsu Iha and Masao Yamada

Chapter 6 Prevention of Human T-Cell Lymphotropic Virus Infection and 
Adult T-Cell Leukemia 105 Makoto Yoshimitsu, Tomohiro Kozako and Naomichi Arima

Chapter 7 The Roles of AMP-Activated Protein Kinase-Related Kinase 5 as 
a Novel Therapeutic Target of Human T-Cell Leukaemia Virus Type 1-Infected T-Cells 119 Mariko Tomita .

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Published by: Unknown - Wednesday, February 20, 2013


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