Open Access Medical Books

TEXTBOOK : ONCOGENOMICS AND CANCER PROTEOMICS – NOVEL APPROACHES IN BIOMARKERS DISCOVERY AND THERAPEUTIC TARGETS IN CANCER

ONCOGENOMICS

Edited by César López-Camarillo and Elena Aréchaga-Ocampo .

238 pages .
Open Access . 

Today, cancer research is focused on determining how genome and proteome level information may be useful as tools in prevention, diagnosis, and prognosis. The development of “omics” technologies, such as proteomics and transcriptomics has opened new research areas for scientists working on cancer research. This book presents the latest advances in cancer genomics and proteomics focused on identification of tumoral biomarkers and potential therapeutic targets in the most common human neoplasias including glioblastoma, oral squamous cell carcinoma, and breast, lung, prostate, and colorectal cancers. In addition, critical reviews of the relevant roles of microRNAs, animal models and the application of gene regulatory networks to validate potential therapeutic targets in cancer are also included.
Chapters in “Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer” present comprehensive and expert perspectives on the most common cancers from bench to bedside applications by an international team of experts in the field. This edited collection is subdivided into two sections titled: I) Genomic expression profiling in cancer, and II) Proteomic expression profiling in cancer. Proteomic technologies based on two-dimensional electrophoresis (2DPAGE and 2D-DIGE), or on isotope labeling methods followed by mass spectrometry (MS) analysis applied to the identification of differential protein expression in cancer are also discussed. This book will contribute greatly to the scientific and medical community by providing up-to-date discoveries of oncogenomics and their important roles in cancer translational research. It is intended for students, scientists, clinicians, oncologists and other health professionals working in the field of cancer research.

Dr. César López-Camarillo
Genomics Sciences Program,
 Autonomous University of Mexico City,
Mexico
Dr. Elena Aréchaga-Ocampo
Cancer Biomedical Research Unit, 
National Institute of Cancerology,
Mexico

CONTENTS :

Section 1 of the textbook : Genomic Expression Profiling in Cancer .


1 Genomic Expression Profiles: From Molecular Signatures to Clinical Oncology Translation 3 Norfilza M. Mokhtar, Nor Azian Murad, Then Sue Mian and Rahman Jamal

2 Biomarkers in Lung Cancer: 
Integration with Radiogenomics Data 49 
Elena Aréchaga-Ocampo, Nicolas Villegas-Sepulveda, 
Eduardo Lopez-Urrutia, Mayra Ramos-Suzarte, 
Cesar Lopez-Camarillo, Carlos Perez-Plasencia, 
Claudia H. Gonzalez-de la Rosa, 
Cesar Cortes-Gonzalez and Luis A. Herrera

3 Functional Roles of microRNAs in Cancer: 
microRNomes and oncomiRs Connection 71 
César López-Camarillo, Laurence A. Marchat, 
Elena Aréchaga-Ocampo, Elisa Azuara-Liceaga, 
Carlos 
Pérez-Plasencia, Lizeth Fuentes-Mera, 
Miguel A. Fonseca-Sánchez and Ali Flores-Pérez

4 Genetic Profiling: 
Searching for Novel Genetic Aberrations in Glioblastoma 91 
Pouya Jamshidi and Clark C. Chen

5 MicroRNAs in Invasion and Metastasis in Lung Cancer 123 
Lili Jiang and Xueshan Qiu

6 The Importance of Cancer Cell Lines 
as in vitro Models in Cancer Methylome Analysis 
and Anticancer Drugs Testing 139 
Daniela Ferreira, Filomena Adega and Raquel Chaves


Section 2 of the textbook : Proteomic Expression Profiling in Cancer .


7 Oncoproteomic Approaches in Lung Cancer Research . 
Mª Dolores Pastor, Ana Nogal, Sonia Molina-Pinelo, 
Luis Paz-Ares and Amancio Carnero

8 Phosphoproteomics-Based Characterization 
of Cancer Cell Signaling Networks 185 
Hiroko Kozuka-Hata, Yumi Goto and Masaaki Oyama

9 Phosphoproteomics for the Mapping of 
Altered Cell Signaling Networks in Breast Cancer 207
Olga Villamar-Cruz and Luis E. Arias-Romero .




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Published by: younes younes - Friday, March 15, 2013

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