Open Access Medical Books



Edited by Andrew Swan .

472 pages . 
Open Access . 

Meiosis, the specialized cell cycle that results in the production of gametes for sexual reproduction, has a long history as a subject of scientific study. It is an important process on many levels with direct relevance to understanding of and treatment of human disease and anneuploidies, and the development of assisted reproductive technologies. A fundamental understanding of meiosis is also essential for the development of new strategies for improving economically important animal and plant species. From a more general perspective, the study of meiosis has also been driven by challenge of understanding such a complex process, and by the recognition of its importance in creating so much of the genetic diversity on our planet.
This book brings together a broad sampling of the current research on meiosis. Each chapter brings a unique perspective and introduces some of the many novel and interesting approaches that are being used in the study of meiosis. The book is divided into three sections. In the first section are chapters dealing with meiosis at the molecular level, using model system approaches. Many of these chapters deal with fundamental processes that are unique to meiosis. For example the first two chapters deal with the synaptonemal complex and lampbrush chromosomes respectively – two structures that have central roles in meiosis. The 3rd chapter deals with another process that is completely unique to meiosis, the bi-orientation of homologous chromosomes onto a spindle in meiosis I. Many processes that occur in meiosis represent complex variations on events in mitosis. An example of this is provided in chapter 4, which deals with the cohesins and their important role in ensuring proper homologue and sister chromatid segregation in meiosis. Chapter 5 discusses spermatogenesis in the genetically tractable Drosophila model system and highlights advances made in this meiotic system that have helped develop our understanding of basic cell biological processes such as cytokinesis. The first section closes with two examples of the amazing diversity of meiosis. Chapter 5 offers a thorough review of the many sex chromosome systems employed by spiders. Chapter 6 provides a fascinating examination of the molecular basis for the non-reductional meiosis that occurs in parthenogenic development of the water flea. The 2nd section of this book deals with meiosis specifically in mammals. The first two chapters in this section deal with the hormonal and signal signaling pathways that regulate the meiotic cell divisions in mammalian cells. Chapter 3 deals with the unique energy requirements of growing oocytes. Chapters 4 and 5 provide examples of some of the unique cell biology of meiosis – the use of apoptotic machinery in meiosis and the use of cytoplasmic structure, the nuage and associated chromatoid bodies.
Chapters 6, 7 and 8 all deal with some of the genomics and proteomics approaches and technologies that are being used both to study meiosis and to improve both animal breeding and medical diagnostics.
The 3rd section of this book deals with meiosis in the plants. The first two chapters deal with cytological approaches to the study of meiosis in plants. Chapter 1 looks specifically at meiosis in the flowering plants, while Chapter 2 gives an example of how the classic cytological approaches are being updated and given new power by advances in imaging and analysis methods. Several chapters here deal with issues of great importance in plant breeding. Chapters 3 and 4 deal with challenges in manipulating polyploid species, including some of the most agriculturally important food crops. Chapters 5 and 6 focus on challenges that are faced in generating interspecific hybrids – in edible alliums in Chapter 5 and in the cacti in Chapter 6.
Chapter 7 deals with meiosis in a plant pathogen, the rust fungi. This final chapter deals with the rusts as both a model system for understanding host/pathogen interactions, and as an important agricultural pest for which an understanding of meiosis will provide new means of biological control.
The incredible breadth of research included in this volume reflects the great complexity and diversity of meiotic processes. It is also a reflection of the great diversity of motivations that have brought researchers to the study meiosis – from a desire to see improvements in medical treatments and diagnostics, to a desire to improve agricultural production, to a fascination with the complexity and diversity of a fundamental biological process.

Dr. Andrew Swan
Assistant Professor
University of Windsor


Part 1 of the textbook : Molecular and Comparative Study of Meiosis in Model Systems .

1 Epigenetics of the Synaptonemal Complex 3 
Abrahan Hernández-Hernández, Rosario Ortiz Hernádez and Gerardo H. Vázquez-Nin

2 Facing the Correct Pole: 
The Challenge of Orienting Chromosomes for Meiotic Divisions 17 Karishma Collette and Györgyi Csankovszki

3 Cohesins and Cohesin-Regulators in Meiosis 35 
Adela Calvente and José L. Barbero

4 Dynamics of Cellular Components in 
Meiotic and Premeiotic Divisions in Drosophila Males 67 Yoshihiro H. Inoue, Chie Miyauchi, Tubasa Ogata and Daishi Kitazawa

5 Sex Chromosomes and Meiosis in Spiders: 
A Review 87 Douglas Araujo, Marielle Cristina Schneider, Emygdio Paula-Neto and Doralice Maria Cella

6 How Does the Alteration of Meiosis Evolve to Parthenogenesis? - Case Study in a Water Flea, Daphnia pulex - 109 Chizue Hiruta and Shin Tochinai

7 Avian Meiotic Chromosomes as Model Objects in Cytogenetics 123 Katarzyna Andraszek and Elżbieta Smalec

Part 2 of the textbook : Molecular Biology of Mammalian Meiosis .

8 The Control of Meiotic Arrest and 
Resumption in Mammalian Oocytes 151 Sylvie Bilodeau-Goeseels and Nora Magyara

9 Energy Metabolism Regulating Mammalian 
Oocyte Maturation 173 N. Songsasen

10 PKC Regulation of Gametogenesis and 
Early Development 187 James J. Faust, Madhavi Kalive, Anup Abraham and David G. Capco

11 Role of Bcl2l10 in Regulation of 
Meiotic Cell Cycle in the Mouse Oocyte 207 Kyung-Ah Lee, Se-Jin Yoon, Eun-Young Kim, Jeehyeon Bae, Hyun-Seo Lee, Su-Yeon Lee and Eun-Ah Kim

12 Nuage Components and Their Contents in 
Mammalian Spermatogenic Cells, as Revealed by Immunoelectron Microscopy 216 Yuko Onohara and Sadaki Yokota

13 Meiotic Behaviour of Chromosomes Involved in 
Structural Chromosomal Abnormalities Determined by Preimplantation Genetic Diagnosis 241 L. Xanthopoulou and H. Ghevaria

14 OMICS for the Identification of Biomarkers for Oocyte Competence, with Special Reference to the Mare as a Prospective Model for Human Reproductive Medicine 257 Maria Elena Dell’Aquila, Yoon Sung Cho, Nicola Antonio Martino, Manuel Filioli Uranio, Lucia Rutigliano and Katrin Hinrichs

15 Insight Into the Molecular Program of Meiosis 283 Hiba Waldman Ben-Asher and Jeremy Don

Part 3 of the textbook : Molecular and Cytogenetic Studies of Plant Meiosis .

16 Quantifying Meiosis: Use of the Fractal Dimension, 
Df, to Describe and Predict Prophase I Substages and Metaphase I 303 Cynthia Ross Friedman and Hua-Feng Wang

17 Haploid Independent Unreductional Meiosis in 
Hexaploid Wheat 321 Filipe Ressurreição, Augusta Barão, Wanda Viegas and Margarida Delgado

18 Meiotic Behavior in Intra- and Interspecific Sexual and 
Somatic Polyploid Hybrids of Some Tropical Species 331 Maria Suely Pagliarini, Maria Lúcia Carneiro Vieira and Cacilda Borges do Valle

19 Meiotic Irregularities in Interspecific Crosses 
Within Edible Alliums 349 Agnieszka Kiełkowska

20 Evaluation of Interspecific-Interploid Hybrids (F1) and 
Back Crosses (BC1) in Hylocereus Species (Cactaceae) 367 Aroldo Cisneros and Noemi Tel-Zur

21 Embryology of Flowering Plants Applied to Cytogenetic 
Studies on Meiosis 389 Jorge E. A. Mariath, André L. L. Vanzela, Eliane Kaltchuk-Santos, Karen L. G. De Toni, Célia G. T. J. Andrade, Adriano Silvério, Erica Duarte-Silva, Carlos R. M. da Silva, Juca A. B. San Martin,
Fernanda Nogueira and Simone P. Mendes

22 Investigating Host Induced Meiosis in 
a Fungal Plant Pathogen 411 B. J. Saville, M. E. Donaldson and C. E. Doyle .

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Published by: Unknown - Tuesday, March 12, 2013


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