Open Access Medical Books



Edited by Brian Ceresa .

466 pages . 
Open Access. 

For decades, endocytosis has been recognized as a fundamental cellular process that regulates the uptake of small molecules (cell surface proteins, bacteria, toxins, etc.) into the cell. So why, after years of study, does this simple process warrant more discussion? Anyone who has examined the endocytic pathway will appreciate that this conceptually simple mechanism is highly complex and sophisticated. Like ballet dancers who make their synchronous performance seem effortless, the cell brings in molecules via a carefully choreographed mechanism. However, closer inspection reveals very specific roles that are dependent on the cargo being internalized. There are differences in the routes of entry into the cell (calthrin-mediated versus nonclathrin dependent), pathways within the cell (recycling versus degradation), and consequences associated with each branch point (i.e. viral replication versus viral senescence). With each branch point there are differences in the resulting cell biology.
There were several goals in writing this book. First, by bringing together researchers that study diverse biological processes, there is a side-by-side comparison of the commonalities and differences of these processes. Second, tools that are standard in one field can often be novel to another. With a common mechanistic link, each story reveals new experimental approaches. Next, the examples in this book help one look beyond the mechanism of endocytosis and onto the functional relevance. How does endocytosis support the life cycle of a virus? Does endocytic trafficking help or hinder the signaling by a receptor? Does the route of entry effect the toxicity of foreign substances? Finally, the later chapters in this book demonstrate ways in which the endocytic process can be harnessed for therapeutic applications.
While endocytosis has been well studied, the work is far from done. This book will be part of the continuum in understanding endocytic trafficking. It is the hope that this book will be useful to scientists who have had a longstanding interest in membrane trafficking, those who have just begun their exploration, and those who need their curiosity satisfied.

Brian P. Ceresa, Ph.D.
Department of Pharmacology
University of Louisville, Louisville, Kentucky,


Section 1 of the textbook : Regulation of Tissue Homeostasis by the Endocytic Pathway .

1 Key Events in Synaptic Vesicle Endocytosis 3 
Frauke Ackermann, Joshua A. Gregory and Lennart Brodin

2 The Vacuole Import and Degradation Pathway 
Converges with the Endocytic Pathway to Cargo to the Vacuole for Degradation 17 Abbas A. Alibhoy and Hui-Ling Chiang

3 The Role of Endocytosis in the Creation of 
the Cortical Division Zone in Plants 41 Ichirou Karahara, L. Andrew Staehelin and Yoshinobu Mineyuki

4 Roles of Cellular Redox Factors in Pathogen 
and Toxin Entry in the Endocytic Pathways 61 Jianjun Sun

Section 2 of the textbook : Using Microscopy to Study Endocytic Trafficking .

5 Advanced Optical Imaging of Endocytosis 93
 Jesse S. Aaron and Jerilyn A. Timlin

6 Imaging of Endocytosis in Paramecium 
by Confocal Microscopy 123 Paola Ramoino, Alberto Diaspro, Marco Fato and Cesare Usai

Section 3 of the textbook : Viruses  .

7 Caveolae-Dependent Endocytosis in Viral Infection 155 
 Norica Branza-Nichita, Alina Macovei and Catalin Lazar

8 Clathrin-Associated Endocytosis as a Route of Entry into Cells for Parvoviruses 183 F. Brent Johnson and Enkhmart Dudleenamjil

9 Endocytosis of Non-Enveloped DNA Viruses 217
 Maude Boisvert and Peter Tijssen

Section 4 of the textbook : Pathogens and Toxins .

10 Pathogen and Toxin Entry – 
How Pathogens and Toxins Induce and Harness Endocytotic Mechanisms 249 Thorsten Eierhoff, Bahne Stechmann and Winfried Römer

11 The Unique Endosomal/Lysosomal 
System of Giardia lamblia 277 Maria C. Touz

Section 5 of the textbook : Cell Surface Receptors .

12 Mutual Regulation of Receptor-Mediated Cell Signalling 
and Endocytosis: EGF Receptor System as an Example 301 Zhixiang Wang

13 Endocytosis in Notch Signaling Activation 331
 Elisa Sala, Luca Ruggiero, Giuseppina Di Giacomo and Ottavio Cremona

14 Hyaluronan Endocytosis: 
Mechanisms of Uptake and Biological Functions 377 Ronny Racine and Mark E. Mummert

15 Identification of Ubiquitin System Factors 
in Growth Hormone Receptor Transport 391 Johan A. Slotman, Peter van Kerkhof, Gerco Hassink, Hendrik J. Kuiken and Ger J. Strous

Section 6 of the textbook : Drug Delivery .

16 Endocytosis of Particle Formulations by Macrophages 
and Its Application to Clinical Treatment 413 Keiji Hirota and Hiroshi Terada

17 Endosomal Escape Pathways 
for Non-Viral Nucleic Acid Delivery Systems 429 Wanling Liang and Jenny K. W. Lam .

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Published by: Unknown - Wednesday, March 13, 2013


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