Open Access Medical Books



Edited by Sanjay K. Srivastava .

324 pages .
Open Access .

Pancreatic cancer is one of the most fatal human malignancies with extremely poor prognosis making it the fourth leading cause of cancer-related deaths in the United States. The molecular mechanisms of pancreatic carcinogenesis are not well understood. The major focus of these two books is towards the understanding of the basic biology of pancreatic carcinogenesis, identification of newer molecular targets and the development of adjuvant and neoadjuvant therapies.
Book 1 on pancreatic cancer provides the reader with an overall understanding of the biology of pancreatic cancer, hereditary, complex signaling pathways and alternative therapies. The book explains nutrigenomics and epigenetics mechanisms such as DNA methylation, which may explain the etiology or progression of pancreatic cancer.
Apart from epigenetics, book summarizes the molecular control of oncogenic pathways such as K-Ras and KLF4. Since pancreatic cancer metastasizes to vital organs resulting in poor prognosis, special emphasis is given to the mechanism of tumor cell invasion and metastasis. Role of nitric oxide and Syk kinase in tumor metastasis is discussed in detail. Prevention strategies for pancreatic cancer are also described. The molecular mechanisms of the anti-cancer effects of curcumin, benzyl isothiocyante and vitamin D are discussed in detail. Furthermore, this book covers the basic mechanisms of resistance of pancreatic cancer to chemotherapy drugs such as gemcitabine and 5- flourouracil. The involvement of various survival pathways in chemo-drug resistance is discussed in depth. Major emphasis is given to the identification of newer therapeutic targets such as mesothalin, glycosylphosphatidylinositol, cell cycle regulatory proteins, glycans, galectins, p53, toll-like receptors, Grb7 and telomerase in pancreatic cancer for drug development.
Book 2 covers pancreatic cancer risk factors, treatment and clinical procedures. It provides an outline of pancreatic cancer genetic risk factors, signaling mechanisms, biomarkers and disorders and systems biology for the better understanding of disease.
As pancreatic cancer suffers from lack of early diagnosis or prognosis markers, this book encompasses stem cell and genetic makers to identify the disease in early stages.
The book uncovers the rationale and effectiveness of monotherapy and combination therapy in combating the devastating disease. As immunotherapy is emerging as an attractive approach to cease pancreatic cancer progression, the present book covers various aspects of immunotherapy including innate, adaptive, active, passive and bacterial approaches. The book also focuses on the disease management and clinical procedures. Book explains the role of pre-existing conditions such as diabetes and smoking in pancreatic cancer. Management of anesthesia during surgery and pain after surgery has been discussed. Book also takes the reader through the role of endoscopy and fine needle guided biopsies in diagnosing and observing the disease progression. As pancreatic cancer is recognized as a major risk factor for vein thromboembolism, this book reviews the basics of coagulation disorders and implication of expandable metallic stents in the management of portal vein stenosis of recurrent and resected pancreatic cancer. Emphasis is given to neuronal invasion of pancreatic tumors along with management of pancreatic neuroendocrine tumors.
We hope that this book will be helpful to the researchers, scientists and patients providing invaluable information of the basic, translational and clinical aspects of pancreatic cancer.

Sanjay K. Srivastava, Ph.D.
Department of Biomedical Sciences
Texas Tech University Health Sciences Center
Amarillo, Texas


 1 The Genetics of Pancreatic Cancer 1 Dagan Efrat and Gershoni-Baruch Ruth

 2 Systems and Network-Centric Understanding of Pancreatic Ductal Adenocarcinoma Signalling 15 Irfana Muqbil, Ramzi M. Mohammad, Fazlul H. Sarkar and Asfar S. Azmi

 3 Novel Biomarkers in Pancreatic Cancer 31 Simona O. Dima, Cristiana Tanase, Radu Albulescu, Anca Botezatu and Irinel Popescu

 4 Medical Therapy of Pancreatic Cancer: Current Status and Future Targets 55 Edward Livshin and Michael Michael

 5 Temporal Trends in Pancreatic Cancer 77 Tadeusz Popiela and Marek Sierzega

 6 Current Perspectives and Future Trends of Systemic Therapy in Advanced Pancreatic Carcinoma 89 Purificacion Estevez-Garcia and Rocio Garcia-Carbonero

 7 Immunotherapy of the Pancreatic Cancer 109 Yang Bo

 8 An Overview on Immunotherapy of Pancreatic Cancer 137 Fabrizio Romano, Luca Degrate, Mattia Garancini, Fabio Uggeri, Gianmaria Mauri and Franco Uggeri

 9 Bacterial Immunotherapy-Antitumoral Potential of the Streptococcal Toxin Streptolysin S- 163 Claudia Maletzki, Bernd Kreikemeyer, Peggy Bodammer, Joerg Emmrich and Michael Linnebacher

 10 Anesthesia and Pain Management: Techniques and Practice 177 Maurizio Marandola and Alida Albante

 11 Multi-Disciplinary Management of Metastatic Pancreatic Cancer 197 Marwan Ghosn, Colette Hanna and Fadi El. Karak

 12 Pancreatic Cancer – Clinical Course and Survival 205 Birgir Gudjonsson

 13 Endoscopic Management of PancreErika Madrigal and Jennifer Chennatatic Cancer: From Diagnosis to Palliative Therapy 213 

 14 Role of Guided – Fine Needle Biopsy of the Pancreatic Lesion 237 Luigi Cavanna, Roberto Di Cicilia, Elisabetta Nobili, Elisa Stroppa, Adriano Zangrandi and Carlo Paties

 15 Coagulation Disorders in Pancreatic Cancer 255 A. Albu, D. Gheban, C. Grad and D.L. Dumitrascu

 16 Clinical Implications of an Expandable Metallic Mesh Stent for Malignant Portal Vein Stenosis in Management of Unresectable or Recurrent Pancreatic Cancer 271 Yoshinori Nio

 17 Pancreatic Neuroendocrine Tumors: Emerging Management Paradigm 271 Syed F. Zafar and Bassel El-Rayes

 18 Generation and Impact of Neural Invasion in Pancreatic Cancer 295 Ihsan Ekin Demir, Helmut Friess and Güralp O. Ceyhan 

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Published by: Unknown - Thursday, March 28, 2013


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