Open Access Medical Books

TANDEM MASS SPECTROMETRY –– APPLICATIONS AND PRINCIPLES

TANDEM MASS SPECTROMETRY

Edited by Jeevan K. Prasain .

788 pages . 
Open Access. 

Over the last two decades tandem mass spectrometry has become one of the most versatile analytical techniques in the study of biochemicals and it is expected to expand further from its classical applications in chemical research to the study of chemical entities at the systems level. The main objective of this book is to provide a current review of the principles and various applications of tandem mass spectrometry. Although there are a number of books dealing with mass spectrometry, there is seemingly no book available in the market that can authoritatively describe the qualitative and quantitative analyses of small and macro molecules by mass spectrometry in a single text. This book comprises 30 chapters and is divided into five main sections. Attempts have been made to offer a detailed discussion on background, experimental methods and results with many illustrations in each chapter.
Thanks are expressed to the contributing authors who have attempted to provide comprehensive review from the basic principles to cutting edge research of mass spectrometry. Finally, I would like to thank Ms. Alida Lesnjakovic, Publishing Process Manager, and other InTech publication staffs for their wonderful support.



Jeevan K. Prasain
Department of Pharmacology & Toxicology
University of Alabama at Birmingham
USA
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CONTENTS :



Part 1 : Introduction .


1 Applications of Tandem Mass Spectrometry: 
From Structural Analysis to Fundamental Studies 3 Paulo J. Amorim Madeira and M. Helena Florêncio

Part 2 : Proteomics/Macromolecular Analysis .


2 Tandem Mass Spectrometry of Peptides 35 
Renata Soares, Elisabete Pires, André M. Almeida, Romana Santos, Ricardo Gomes, Kamila Koci, Catarina Ferraz Franco and Ana Varela Coelho

3 Evolutionary Proteomics: Empowering 
Tandem Mass Spectrometry and Bioinformatics Tools for the Study of Evolution 57 Irving E. Vega, Dan Rittschof, Gary H. Dickinson and Ian Musgrave

4 Proteomic Strategies for Comprehensive Identification 
of Post-Translational Modifications of Cellular Proteins Including Low Abundant and Novel Modifications 87 Jaeho Jeong, Jae-Jin Lee and Kong-Joo Lee

5 Tandem Mass Spectrometry and Glycoproteins 105 
Pavlina Dolashka

6 Proteomics Methodology Applied to 
the Analysis of Filamentous Fungi - New Trends
for an Impressive Diverse Group of Organisms 127 Carlos Barreiro, Carlos García-Estrada and Juan F. Martín

7 ETD and ECD Mass Spectrometry 
Fragmentation for the Characterization of Protein Post Translational Modifications 161 Lisa Elviri

8 Tandem Mass Spectrometry for Simultaneous 
Qualitative and Quantitative Analysis of Protein 179 Lay-Harn Gam

9 Comparative Proteomics of Tandem Mass Spectrometry Analyses for Bacterial Strains Identification and Differentiation 199 Rabih E. Jabbour, Mary M. Wade, Samir V. Deshpande, Michael F. Stanford, Alan W. Zulich and A. Peter Snyder

10 The Use of Mass Spectrometry 
for Characterization of Fungal Secretomes 221 Eduardo Callegari and Mario Navarrete

11 Strategies and Challenges in Measuring 
Protein Abundance Using Stable Isotope Labeling and Tandem Mass Spectrometry 235 Kolbrun Kristjansdottir, Satoe Takahashi, Samuel L. Volchenboum and Stephen J. Kron

12 The Use of Mass Spectrometry in Characterization of 
Bone Morphogenetic Proteins from Biological Samples 259 Genadij Razdorov and Slobodan Vukicevic

13 Tandem Mass Spectrometry of Tagged 
and Permethylated Polysaccharides 285 Wen-Bin Yang

Part 3 : Metabolite Identification and Quantification .


14 Metabolomics Research 
with Tandem Mass Spectrometry 309 Guo-Fang Zhang, Qingling Li, Ling Li and Takhar Kasumov

15 Determination of Ractopamine Residues 
in Pigs by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry 331 Jelka Pleadin, Ana Vulic, Nina Perši and Wolfgang Radeck

16 Simultaneous LC-MS/MS Determination of Racemic 
Warfarin and Etravirine in Rat Plasma and Its Application in Pharmacokinetic Studies 355 Jyothy John, Keila Robinson, Mathew John, Jason Caballero, Jing Ma, Dong Liang and Cyril Abobo

17 Application of Tandem 
Mass Spectrometry for Analyzing Melamine 373 Wei-Chih Cheng and I-Jen Wang

18 Identifying and Overcoming 
Matrix Effects in Drug Discovery and Development 389 Terence G. Hall, Inese Smukste, Karen R. Bresciano, Yunxia Wang, David McKearn and Ronald E. Savage

19 Evaluating PK/PD Relationship of CNS Drug by Using Liquid Chromtography/Tandem Mass Spectrometry Coupled to In Vivo Microdialysis 421 Ying Qu, Loren Olson, Xiaohui Jiang, Leah Aluisio, Christopher King, Elliott B. Jones and Timothy W. Lovenberg

20 Principles and Applications of LC-MS/MS 
for the Quantitative Bioanalysis of Analytes in Various Biological Samples 441 Ju-Seop Kang

21 HPLC-MS/MS of Highly Polar Compounds 493 
Luigi Silvestro, Isabela Tarcomnicu and Simona Rizea Savu

22 Quantification of Glucuronide 
Metabolites in Biological Matrices by LC-MS/MS 531 Jurij Trontelj

23 Tandem Mass Spectrometry 
of Alkanolamines in Environmental Samples 559 John Headley, Kerry Peru, Adeola Adenugba and Dena McMartin

24 Application of Tandem Mass Spectrometry in Chemical Kinetics 581 Jinping Qiao

Part 4 : Natural Products Analysis .


25 Electrospray Ionization Tandem Mass 
Spectrometry as a Tool for the Structural Elucidation
and Dereplication of Natural Products: An Overview 595 Herbert Júnior Dias, Nathalya Isabel de Melo and Antônio Eduardo Miller Crotti

26 From the Collisionally Induced Dissociation to the Enzyme-Mediated Reactions: The Electron Flux Within the Lignan Furanic Ring 619 Andreina Ricci and Simona Piccolella

Part 5 : Lipidomics and Clinical Applications .


27 Characterization of Phospholipid Molecular Species 
by Means of HPLC-Tandem Mass Spectrometry 637 Natale G. Frega, Deborah Pacetti and Emanuele Boselli

28 Clinical Applications 673 
Joseph Herman and Bori Shushan

29 Tandem Mass Spectrometry of Sphingolipids: 
Application in Metabolic Studies and Diagnosis
of Inherited Disorders of Sphingolipid Metabolism 721 Ladislav Kuchar, Befekadu Asfaw and Jana Ledvinová

30 Newborn Screening by Tandem Mass 
Spectrometry: Impacts, Implications and Perspectives 751 François Rousseau, Yves Giguère, Marie-Thérèse Berthier, Dominique Guérette, Jean-Guy Girard and Michel Déry .


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