Open Access Medical Books



Edited by Maria Laura Garcia and Víctor Romanowski .

314 pages . 
Open Access . 

Viral genomes are diverse in size and molecular structure. The bacteriophage MS2 genome is one of the smallest known; it encodes just four genes: maturation protein (A-protein), coat protein, replicase protein, and lysis. However, the expression of these proteins depends upon a complex interplay between translation and RNA secondary structure. It was the first fully sequenced viral genome (1): it took more than five years to determine the 3,569 nucleotides long single-stranded RNA of MS2 phage (1976). A year later the ΦX174 circular single-stranded DNA genome of 5,386 nucleotides, encoding 11 proteins, was published (2). These two genomes were the first to be determined in scientific history.
It has been a long way since these fabulous achievements of the early years molecular biology. Long before the advent of recombinant DNA technology, viruses (having a discrete number of genes) were indeed the first tools at hand to explore the mechanisms of genome replication and gene expression.
Several leaps in sequencing strategies and technological advances (a blend of chemistry, enzymology, robotics and computer sciences) have increased our potential to molecularly describe new viral genomes in virtually no-time. Advances in molecular cloning and cell biology have also had a great impact on our understanding of virus infections and paved the way to new therapies.
This book compiles chapters written by experts on diferent aspects of selected viruses with DNA and RNA genomes that are pathogens for humans, other animals and plants. They represent just a sample of the smallest genomes (ranging from several thousands to hundreds of thousands nucleotides) that “come to life” when they succeed infecting a susceptible host cell. The molecular structures of viral genomes are as diverse as the molecularly exquisite alternatives of interactions with their host targets. The different chapters visit fundamental concepts of contemporary Virology.
Although many edges of viral biology touch upon several aspects in an intertwigned manner (genomics, cell biology, pathogenesis, etc.), the chapters have been arranged in sections according to the main issues raised in each of them.

Profs. María Laura García and Víctor Romanowski
Instituto de Biotecnología y Biología Molecular
Facultad de Ciencias Exactas
Universidad Nacional de La Plata


Part 1 of the textbook : Virus Genomes Organization and Functions .

 1 The Baculoviral Genome 3
M. Leticia Ferrelli, Marcelo F. Berretta, Mariano N. Belaich, P. Daniel Ghiringhelli, Alicia Sciocco-Cap and Víctor Romanowski

 2 Nudivirus Genomics and Phylogeny 33
Yongjie Wang, Olaf R.P. Bininda-Emonds, and Johannes A. Jehle

 3 Foot and Mouth Disease Virus Genome 53
Consuelo Carrillo

 4 Ophioviruses: State of the Art 69
Maria Laura Garcia

Part 2 of the textbook : Regulation of Viral Replication and Gene Expression .

 5 Ribosomal Frameshift Signals in Viral Genomes 91
Ewan P. Plant

 6 Cis–Acting RNA Elements of Human Immunodeficiency Virus 123
Mario P.S. Chin

 7 Hepatitis B Virus X Protein: A Key Regulator of the Virus Life Cycle 141
Julie Lucifora and Ulrike Protzer

Part 3 of the textbook : Genomic Sequence Diversity and Evolution .

 8 Application of a Microarray-Based Assay for the Study of Genetic Diversity of West Nile Virus 157
Andriyan Grinev, Zhong Lu, Vladimir Chizhikov and Maria Rios

 9 Microarray Techniques for Evaluation of Genetic Stability of Live Viral Vaccines 181
Majid Laassri, Elena Cherkasova, Mones S. Abu-Asab and Konstantin Chumakov

 10 Inter- and Intra-Host Evolution of Dengue Viruses and the Inference to the Pathogenesis 195
Day-Yu Chao

Part 4 of the textbook : Host-Virus Interactions .

 11 Flavivirus Neurotropism, Neuroinvasion, Neurovirulence and Neurosusceptibility: Clues to Understanding Flavivirus- and Dengue-Induced Encephalitis 219
Myriam Lucia Velandia and Jaime E. Castellanos

 12 Vaccines and Antiviral Drugs for Diseases Associated with the Epstein-Barr Virus 241
Limin Chen, Ning Li and Cheng Luo

 13 Identification of Aquatic Birnavirus VP3 Death Domain and Its Dynamic Interaction Profiles in Early and Middle Replication Stages in Fish Cells 261
Jiann-Ruey Hong and Jen-Leih Wu

 14 Molecular Virology and Pathogenicity of Citrus tristeza virus 275
Maria R. Albiach-Marti .

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Published by: Unknown - Wednesday, March 6, 2013


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